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Study · In vitro (cells) · 2024

7 results

Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth Muscle Cell Migration.

Balraj P, Ambhore NS, Ramakrishnan YS, Borkar NA, Banerjee P, Reza MI, Varadharajan S, Kumar A, Pabelick CM, Prakash YS, Sathish V

American journal of respiratory cell and molecular biology1 Jun 2024Cited by 12 (Europe PMC)

PMID38512807 (opens in a new tab)PMCIDPMC11160419 (opens in a new tab)DOI10.1165/rcmb.2023-0469oc (opens in a new tab)PepBankPUB-38512807
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human airway smooth muscle cells, Kp-10 significantly inhibited PDGF-induced cell migration, which KISS1R shRNA confirmed.

    In plain wordsIn lab-grown human airway muscle cells, kisspeptin‑10 slowed growth-factor-driven cell movement.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePDGF-induced ASM cell migration
    Study

    humann: not reported in source

    Human airway smooth muscle cells exposed to PDGF
    Outcome group
    Cancer cell invasion and metastasis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KISS1R activation using Kp-10 significantly inhibited PDGF-induced ASM cell migration, further confirmed using KISS1R shRNA.
    1 context sentence
    Summary · context
    Here, we examined the mechanisms by which KISS1R activation regulates mitogen-induced ASM cell migration.
  2. 02LabIn vitro (cells)Mechanism

    In human airway smooth muscle cells, KISS1R activation modulated F/G actin dynamics.

    In plain wordsIn lab-grown human airway muscle cells, activating the kisspeptin receptor changed actin dynamics.

    Peptide
    Kisspeptin-10
    Outcome
    Direction not reportedF/G actin dynamics
    Study

    humann: not reported in source

    Human airway smooth muscle cells exposed to PDGF
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, KISS1R activation modulated F/G actin dynamics and the expression of promigration proteins like CDC42 (cell division control protein 42) and cofilin.
    1 context sentence
    Summary · context
    Here, we examined the mechanisms by which KISS1R activation regulates mitogen-induced ASM cell migration.
  3. 03LabIn vitro (cells)Mechanism

    In human airway smooth muscle cells, KISS1R activation modulated expression of the promigration proteins CDC42 and cofilin.

    In plain wordsIn lab-grown human airway muscle cells, activating the kisspeptin receptor changed levels of two cell-movement proteins.

    Peptide
    Kisspeptin-10
    Outcome
    Direction not reportedCDC42 and cofilin expression
    Study

    humann: not reported in source

    Human airway smooth muscle cells exposed to PDGF
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, KISS1R activation modulated F/G actin dynamics and the expression of promigration proteins like CDC42 (cell division control protein 42) and cofilin.
    1 context sentence
    Summary · context
    Here, we examined the mechanisms by which KISS1R activation regulates mitogen-induced ASM cell migration.
  4. 04LabIn vitro (cells)Mechanism

    In human airway smooth muscle cells, KISS1R activation reduced RhoA-GTPase.

    In plain wordsIn lab-grown human airway muscle cells, activating the kisspeptin receptor lowered RhoA-GTPase.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseRhoA-GTPase activity
    Study

    humann: not reported in source

    Human airway smooth muscle cells exposed to PDGF
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, we observed reduced ASM RhoA-GTPAse with KISS1R activation.
    1 context sentence
    Summary · context
    Here, we examined the mechanisms by which KISS1R activation regulates mitogen-induced ASM cell migration.
  5. 05LabIn vitro (cells)Mechanism

    In human airway smooth muscle cells, a PKA-inhibitory peptide abolished the antimigratory effect of KISS1R activation.

    In plain wordsIn lab-grown human airway muscle cells, blocking PKA removed the anti-movement effect of kisspeptin receptor activation.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableAntimigratory effect after PKA inhibition
    Study

    humann: not reported in source

    Human airway smooth muscle cells exposed to PDGF
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The antimigratory effect of KISS1R was abolished by PKA (protein kinase A)-inhibitory peptide.
    1 context sentence
    Summary · context
    Here, we examined the mechanisms by which KISS1R activation regulates mitogen-induced ASM cell migration.
  6. 06LabIn vitro (cells)Mechanism

    In PDGF-exposed human airway smooth muscle cells, KISS1R activation significantly increased cAMP.

    In plain wordsIn lab-grown human airway muscle cells, activating the kisspeptin receptor raised cAMP.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasecAMP level
    Study

    humann: not reported in source

    Human airway smooth muscle cells exposed to PDGF
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Conversely, KISS1R activation significantly increased cAMP and phosphorylation of CREB (cAMP-response element binding protein) in PDGF-exposed ASM cells.
    1 context sentence
    Summary · context
    Here, we examined the mechanisms by which KISS1R activation regulates mitogen-induced ASM cell migration.
  7. 07LabIn vitro (cells)Mechanism

    In PDGF-exposed human airway smooth muscle cells, KISS1R activation significantly increased CREB phosphorylation.

    In plain wordsIn lab-grown human airway muscle cells, activating the kisspeptin receptor raised CREB phosphorylation.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseCREB phosphorylation
    Study

    humann: not reported in source

    Human airway smooth muscle cells exposed to PDGF
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Conversely, KISS1R activation significantly increased cAMP and phosphorylation of CREB (cAMP-response element binding protein) in PDGF-exposed ASM cells.
    1 context sentence
    Summary · context
    Here, we examined the mechanisms by which KISS1R activation regulates mitogen-induced ASM cell migration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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