Chronic pramlintide decreases feeding via a reduction in meal size in male rats.

Kern KA, DiBrog AM, Kaur K, Przybysz JT, Mietlicki-Baase EG

Peptides15 Mar 2024Cited by 4 (Europe PMC)

PMID38493922PMCIDPMC11323829DOI10.1016/j.peptides.2024.171197PepBankPUB-38493922

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In male rats, repeated pramlintide decreased chow intake compared with vehicle.
In plain wordsIn male rats, repeated pramlintide reduced chow intake compared with vehicle.
Peptide
Pramlintide (Symlin)
Outcome
DecreaseChow intake
Study
ratsn: not reported in source
Male rats
Comparator
Vehicle
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intraperitoneal · 1 weekAs given in this study (rats).
Source sentences
Summary
Consistent with our hypothesis, pramlintide decreased chow intake mainly via suppression of meal size, with corresponding reductions in meal duration on several days.
1 context sentence(design, population, supporting numbers)
Summary · context
Male rats were given b.i.d. administration of intraperitoneal pramlintide or vehicle for 1 week, and chow intake, meal patterns, and body weight were monitored throughout the test period.
Report a problemFND-3849392201
02AnimalAnimal study (in vivo)Efficacy outcome
In male rats, repeated pramlintide suppressed meal size compared with vehicle.
In plain wordsIn male rats, repeated pramlintide reduced meal size compared with vehicle.
Peptide
Pramlintide (Symlin)
Outcome
DecreaseMeal size
Study
ratsn: not reported in source
Male rats
Comparator
Vehicle
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intraperitoneal · 1 weekAs given in this study (rats).
Source sentences
Summary
Consistent with our hypothesis, pramlintide decreased chow intake mainly via suppression of meal size, with corresponding reductions in meal duration on several days.
1 context sentence(design, population, supporting numbers)
Summary · context
Male rats were given b.i.d. administration of intraperitoneal pramlintide or vehicle for 1 week, and chow intake, meal patterns, and body weight were monitored throughout the test period.
Report a problemFND-3849392202
03AnimalAnimal study (in vivo)Efficacy outcome
In male rats, repeated pramlintide reduced meal duration on several days compared with vehicle.
In plain wordsIn male rats, repeated pramlintide shortened meals on several days compared with vehicle.
Peptide
Pramlintide (Symlin)
Outcome
DecreaseMeal duration
Study
ratsn: not reported in source
Male rats
Comparator
Vehicle
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intraperitoneal · 1 weekAs given in this study (rats).
Source sentences
Summary
Consistent with our hypothesis, pramlintide decreased chow intake mainly via suppression of meal size, with corresponding reductions in meal duration on several days.
1 context sentence(design, population, supporting numbers)
Summary · context
Male rats were given b.i.d. administration of intraperitoneal pramlintide or vehicle for 1 week, and chow intake, meal patterns, and body weight were monitored throughout the test period.
Report a problemFND-3849392203
04AnimalAnimal study (in vivo)Efficacy outcome
In male rats, pramlintide showed fewer effects on meal number or feeding rate than its other feeding effects versus vehicle.
In plain wordsIn male rats, pramlintide showed fewer effects on meal number or feeding rate versus vehicle than on other feeding measures.
Peptide
Pramlintide (Symlin)
Outcome
Direction not reportedMeal number or feeding rate effects
Study
ratsn: not reported in source
Male rats
Comparator
Vehicle
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intraperitoneal · 1 weekAs given in this study (rats).
Source sentences
Summary
Fewer effects on meal number or feeding rate were detected.
1 context sentence(design, population, supporting numbers)
Summary · context
Male rats were given b.i.d. administration of intraperitoneal pramlintide or vehicle for 1 week, and chow intake, meal patterns, and body weight were monitored throughout the test period.
Report a problemFND-3849392204
05AnimalAnimal study (in vivo)Efficacy outcome
In male rats, repeated pramlintide reduced weight gain over the study compared with vehicle.
In plain wordsIn male rats, repeated pramlintide reduced weight gain compared with vehicle.
Peptide
Pramlintide (Symlin)
Outcome
DecreaseWeight gain
Study
ratsn: not reported in source
Male rats
Comparator
Vehicle
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · intraperitoneal · 1 weekAs given in this study (rats).
Source sentences
Summary
Pramlintide also reduced weight gain over the 1-week study.
1 context sentence(design, population, supporting numbers)
Summary · context
Male rats were given b.i.d. administration of intraperitoneal pramlintide or vehicle for 1 week, and chow intake, meal patterns, and body weight were monitored throughout the test period.
Report a problemFND-3849392205

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

Keywords

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