Reparative osteogenesis in mandible in cases of filling a bone defect with hydroxyapatite-containing osteotropic material and injecting the surrounding soft tissues with thymalin: experimental and morphological study.

Boiko AA, Malanchuk VA, Myroshnychenko MS

Wiadomosci lekarskie (Warsaw, Poland : 1960)1 Jan 2024Cited by 1 (Europe PMC)

PMID38431810DOI10.36740/wlek202401110PepBankPUB-38431810

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study17

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone17

In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymalin.

01AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats with mandibular defects, thymalin with Biomin GT activated reparative osteogenesis.
In plain wordsIn rats with jaw defects, thymalin with Biomin GT increased bone repair.
Peptide
Thymalin
Outcome
IncreaseReparative osteogenesis
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In this study, it was shown by the authors an activation of reparative osteogenesis in the lower jaw under conditions of simultaneous filling the bone defect with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injection the surrounding bone defect soft tissue with thymalin.
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181001
02AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material accelerated removal of necrotic tissue and hematoma fragments from mandibular defects.
In plain wordsIn rats, thymalin with bone graft material accelerated removal of dead tissue and blood clot fragments from jaw defects.
Peptide
Thymalin
Outcome
IncreaseRemoval of necrotic tissue and hematoma fragments
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Stimulation of reparative osteogenesis in the lower jaw of rats occurred due to rapid cleaning of the bone defect cavity from necrotic tissues and hematoma fragments
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181002
03AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material decreased neutrophil leukocyte numbers during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material reduced neutrophil numbers during jaw repair.
Peptide
Thymalin
Outcome
DecreaseNeutrophil leukocyte number
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
a decrease in the number of neutrophil leukocytes, an increase in the number and morphofunctional state of monocytes, macrophages, lymphocytes, cells of fibroblastic differon
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181003
04AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material increased monocyte numbers during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material changed monocyte numbers during jaw repair.
Peptide
Thymalin
Outcome
IncreaseMonocyte number
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
a decrease in the number of neutrophil leukocytes, an increase in the number and morphofunctional state of monocytes, macrophages, lymphocytes, cells of fibroblastic differon
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181004
05AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material increased macrophage numbers during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material changed macrophage numbers during jaw repair.
Peptide
Thymalin
Outcome
IncreaseMacrophage number
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
a decrease in the number of neutrophil leukocytes, an increase in the number and morphofunctional state of monocytes, macrophages, lymphocytes, cells of fibroblastic differon
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181005
06AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material increased lymphocyte numbers during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material changed lymphocyte numbers during jaw repair.
Peptide
Thymalin
Outcome
IncreaseLymphocyte number
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
a decrease in the number of neutrophil leukocytes, an increase in the number and morphofunctional state of monocytes, macrophages, lymphocytes, cells of fibroblastic differon
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181006
07AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material increased fibroblastic differon cell numbers during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material changed fibroblast lineage cell numbers during jaw repair.
Peptide
Thymalin
Outcome
IncreaseFibroblastic differon cell number
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
a decrease in the number of neutrophil leukocytes, an increase in the number and morphofunctional state of monocytes, macrophages, lymphocytes, cells of fibroblastic differon
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181007
08AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material produced stage-dependent increases or decreases in osteoblast numbers during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material changed bone-forming cell numbers during jaw repair.
Peptide
Thymalin
Outcome
MixedOsteoblast number
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
balanced change (increase or decrease) in the number and morphofunctional state of bone forming osteoblasts and bone resorbing osteoclasts depending on the stage of reparative osteogenesis
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181008
09AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material produced stage-dependent increases or decreases in osteoclast numbers during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material changed bone-resorbing cell numbers during jaw repair.
Peptide
Thymalin
Outcome
MixedOsteoclast number
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
balanced change (increase or decrease) in the number and morphofunctional state of bone forming osteoblasts and bone resorbing osteoclasts depending on the stage of reparative osteogenesis
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181009
10AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material activated hematopoiesis in lamellar bone tissue of the mandibular regenerate.
In plain wordsIn rats, thymalin with bone graft material increased blood cell production in repaired jaw bone.
Peptide
Thymalin
Outcome
IncreaseHematopoiesis in lamellar regenerate
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
activation of hematopoietic processes in lamellar bone tissue from the regenerate
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181010
11AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material activated bone mineralization during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material increased mineralization during jaw repair.
Peptide
Thymalin
Outcome
IncreaseBone mineralization
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
activation of bone tissue mineralization processes.
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181011
12AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material increased monocyte morphofunctional state during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material changed monocyte structure and function during jaw repair.
Peptide
Thymalin
Outcome
IncreaseMonocyte morphofunctional state
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
a decrease in the number of neutrophil leukocytes, an increase in the number and morphofunctional state of monocytes, macrophages, lymphocytes, cells of fibroblastic differon
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181012
13AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material increased macrophage morphofunctional state during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material changed macrophage structure and function during jaw repair.
Peptide
Thymalin
Outcome
IncreaseMacrophage morphofunctional state
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
a decrease in the number of neutrophil leukocytes, an increase in the number and morphofunctional state of monocytes, macrophages, lymphocytes, cells of fibroblastic differon
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181013
14AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material increased lymphocyte morphofunctional state during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material changed lymphocyte structure and function during jaw repair.
Peptide
Thymalin
Outcome
IncreaseLymphocyte morphofunctional state
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
a decrease in the number of neutrophil leukocytes, an increase in the number and morphofunctional state of monocytes, macrophages, lymphocytes, cells of fibroblastic differon
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181014
15AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material increased fibroblastic differon cell morphofunctional state during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material changed fibroblast lineage cell structure and function during jaw repair.
Peptide
Thymalin
Outcome
IncreaseFibroblastic differon cell morphofunctional state
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
a decrease in the number of neutrophil leukocytes, an increase in the number and morphofunctional state of monocytes, macrophages, lymphocytes, cells of fibroblastic differon
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181015
16AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material produced stage-dependent increases or decreases in osteoblast morphofunctional state during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material changed bone-forming cell structure and function during jaw repair.
Peptide
Thymalin
Outcome
MixedOsteoblast morphofunctional state
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
balanced change (increase or decrease) in the number and morphofunctional state of bone forming osteoblasts and bone resorbing osteoclasts depending on the stage of reparative osteogenesis
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181016
17AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome
In rats, thymalin with bone graft material produced stage-dependent increases or decreases in osteoclast morphofunctional state during mandibular repair.
In plain wordsIn rats, thymalin with bone graft material changed bone-resorbing cell structure and function during jaw repair.
Peptide
Thymalin
Outcome
MixedOsteoclast morphofunctional state
Study
ratn: not reported in source
Mandibular bone defect
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
balanced change (increase or decrease) in the number and morphofunctional state of bone forming osteoblasts and bone resorbing osteoclasts depending on the stage of reparative osteogenesis
1 context sentence(design, population, supporting numbers)
Summary · context
Group 4 included 12 rats with a simulated holey defect in the lower jaw followed by its closure with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-3843181017

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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