Kisspeptin prevents pregnancy loss by modulating the immune microenvironment at the maternal-fetal interface in recurrent spontaneous abortion.

Yang Y, Song S, Gu S, Gu Y, Zhao P, Li D, Cheng W, Liu C, Zhang H

American journal of reproductive immunology (New York, N.Y. : 1989)1 Feb 2024Cited by 8 (Europe PMC)

PMID38414308DOI10.1111/aji.13818PepBankPUB-38414308

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice with recurrent spontaneous abortion, KP10 increased the proportion of Treg cells.
In plain wordsIn mice with recurrent pregnancy loss, kisspeptin‑10 raised the share of regulatory T cells.
Peptide
Kisspeptin-10
Outcome
IncreaseTreg cell proportion in RSA mice
Study
mousen: not reported in source
Recurrent spontaneous abortion mouse model (CBA/J x DBA/2)
Comparator
PBS
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · tail vein injectionAs given in this study (mouse).
Source sentences
Summary
The findings revealed that the proportion of Treg cells, MDSCs, and M2 macrophages in RSA mice was lower than that in NP mice, but it increased following the tail vein injection of KP10.
1 context sentence(design, population, supporting numbers)
Summary · context
NP mice received tail vein injections of PBS and KP234 (blocker of kisspeptin receptor), whereas RSA mice received PBS and KP10 (active fragment of kisspeptin).
Report a problemFND-3841430801
02AnimalAnimal study (in vivo)Efficacy outcome
In mice with recurrent spontaneous abortion, KP10 increased the proportion of MDSCs.
In plain wordsIn mice with recurrent pregnancy loss, kisspeptin‑10 raised the share of myeloid-derived suppressor cells.
Peptide
Kisspeptin-10
Outcome
IncreaseMDSC proportion in RSA mice
Study
mousen: not reported in source
Recurrent spontaneous abortion mouse model (CBA/J x DBA/2)
Comparator
PBS
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · tail vein injectionAs given in this study (mouse).
Source sentences
Summary
The findings revealed that the proportion of Treg cells, MDSCs, and M2 macrophages in RSA mice was lower than that in NP mice, but it increased following the tail vein injection of KP10.
1 context sentence(design, population, supporting numbers)
Summary · context
NP mice received tail vein injections of PBS and KP234 (blocker of kisspeptin receptor), whereas RSA mice received PBS and KP10 (active fragment of kisspeptin).
Report a problemFND-3841430802
03AnimalAnimal study (in vivo)Efficacy outcome
In mice with recurrent spontaneous abortion, KP10 increased the proportion of M2 macrophages.
In plain wordsIn mice with recurrent pregnancy loss, kisspeptin‑10 raised the share of M2 macrophages.
Peptide
Kisspeptin-10
Outcome
IncreaseM2 macrophage proportion in RSA mice
Study
mousen: not reported in source
Recurrent spontaneous abortion mouse model (CBA/J x DBA/2)
Comparator
PBS
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · tail vein injectionAs given in this study (mouse).
Source sentences
Summary
The findings revealed that the proportion of Treg cells, MDSCs, and M2 macrophages in RSA mice was lower than that in NP mice, but it increased following the tail vein injection of KP10.
1 context sentence(design, population, supporting numbers)
Summary · context
NP mice received tail vein injections of PBS and KP234 (blocker of kisspeptin receptor), whereas RSA mice received PBS and KP10 (active fragment of kisspeptin).
Report a problemFND-3841430803
04AnimalAnimal study (in vivo)Efficacy outcome
In mice with recurrent spontaneous abortion, the proportion of gamma-delta T cells changed in the opposite direction to Treg cells, MDSCs and M2 macrophages after KP10.
In plain wordsIn mice with recurrent pregnancy loss, the share of gamma-delta T cells moved the opposite way to the other immune cells.
Peptide
Kisspeptin-10
Outcome
DecreaseGamma-delta T cell proportion in RSA mice
Study
mousen: not reported in source
Recurrent spontaneous abortion mouse model (CBA/J x DBA/2)
Comparator
PBS
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · tail vein injectionAs given in this study (mouse).
Source sentences
Summary
However, the trend of γδT cell proportion change is contrary to these cells.
2 context sentences(design, population, supporting numbers)
Summary · context
The findings revealed that the proportion of Treg cells, MDSCs, and M2 macrophages in RSA mice was lower than that in NP mice, but it increased following the tail vein injection of KP10.
Summary · context
NP mice received tail vein injections of PBS and KP234 (blocker of kisspeptin receptor), whereas RSA mice received PBS and KP10 (active fragment of kisspeptin).
Report a problemFND-3841430804

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

05AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome
In normally pregnant mice, the kisspeptin receptor blocker KP234 reduced the proportion of Treg cells, MDSCs and M2 macrophages.
In plain wordsIn normally pregnant mice, a kisspeptin receptor blocker lowered the share of these immune cells.
Peptide
Kisspeptin-10
Outcome
DecreaseTreg, MDSC and M2 macrophage proportions after KP234 in normal pregnancy mice
Study
mousen: not reported in source
Normal pregnancy mouse model (CBA/J x BALB/c)
Comparator
PBS
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Conversely, the proportion of these cells was reduced in NP mice after the injection of KP234.
1 context sentence(design, population, supporting numbers)
Summary · context
NP mice received tail vein injections of PBS and KP234 (blocker of kisspeptin receptor), whereas RSA mice received PBS and KP10 (active fragment of kisspeptin).
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-3841430805

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.