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Study · Animal study (in vivo) · mouse · 2024

6 results

SS-31 inhibits mtDNA-cGAS-STING signaling to improve POCD by activating mitophagy in aged mice.

Ji Y, Ma Y, Ma Y, Wang Y, Zhao X, Jin D, Xu L, Ge S

Inflammation research : official journal of the European Histamine Research Society ... [et al.]27 Feb 2024Cited by 29 (Europe PMC)

PMID38411634 (opens in a new tab)DOI10.1007/s00011-024-01860-1 (opens in a new tab)PepBankPUB-38411634
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice with surgery-associated neurocognitive dysfunction, SS‑31 improved neural damage.

    In plain wordsIn aged mice after surgery, SS‑31 reduced damage to nerve cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNeural damage after surgery in aged mice
    Study

    mousen: not reported in source

    Tibial fracture surgery in 18-month-old mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study revealed that SS-31 interacted with PHB2 to activate mitophagy and improve neural damage in surgically aged mice, which was attributed to the reduced cGAS-STING pathway and M1 microglial polarization by decreased release of mitochondrial DNA (mtDNA) but not nuclear DNA (nDNA).
    1 context sentence
    Summary · context
    Internal fixation of tibial fracture was performed in 18-month-old mice to induce surgery-associated neurocognitive dysfunction.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In aged mice after tibial fracture surgery, SS‑31 interacted with PHB2 and activated mitophagy.

    In plain wordsIn aged mice after surgery, SS‑31 switched on the cell process that clears damaged mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitophagy activation
    Study

    mousen: not reported in source

    Tibial fracture surgery in 18-month-old mice
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study revealed that SS-31 interacted with PHB2 to activate mitophagy and improve neural damage in surgically aged mice, which was attributed to the reduced cGAS-STING pathway and M1 microglial polarization by decreased release of mitochondrial DNA (mtDNA) but not nuclear DNA (nDNA).
    1 context sentence
    Summary · context
    Internal fixation of tibial fracture was performed in 18-month-old mice to induce surgery-associated neurocognitive dysfunction.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In aged mice after tibial fracture surgery, SS‑31 reduced cGAS-STING pathway signaling.

    In plain wordsIn aged mice after surgery, SS‑31 lowered activity of an inflammation signaling pathway.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasecGAS-STING pathway activity
    Study

    mousen: not reported in source

    Tibial fracture surgery in 18-month-old mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study revealed that SS-31 interacted with PHB2 to activate mitophagy and improve neural damage in surgically aged mice, which was attributed to the reduced cGAS-STING pathway and M1 microglial polarization by decreased release of mitochondrial DNA (mtDNA) but not nuclear DNA (nDNA).
    1 context sentence
    Summary · context
    Internal fixation of tibial fracture was performed in 18-month-old mice to induce surgery-associated neurocognitive dysfunction.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In aged mice after tibial fracture surgery, SS‑31 reduced M1 microglial polarization.

    In plain wordsIn aged mice after surgery, SS‑31 reduced the shift of brain immune cells to an inflammatory state.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseM1 microglial polarization
    Study

    mousen: not reported in source

    Tibial fracture surgery in 18-month-old mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study revealed that SS-31 interacted with PHB2 to activate mitophagy and improve neural damage in surgically aged mice, which was attributed to the reduced cGAS-STING pathway and M1 microglial polarization by decreased release of mitochondrial DNA (mtDNA) but not nuclear DNA (nDNA).
    1 context sentence
    Summary · context
    Internal fixation of tibial fracture was performed in 18-month-old mice to induce surgery-associated neurocognitive dysfunction.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In aged mice after tibial fracture surgery, SS‑31 decreased release of mitochondrial DNA but not nuclear DNA.

    In plain wordsIn aged mice after surgery, SS‑31 lowered release of mitochondrial DNA, but not nuclear DNA.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial DNA release
    Study

    mousen: not reported in source

    Tibial fracture surgery in 18-month-old mice
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study revealed that SS-31 interacted with PHB2 to activate mitophagy and improve neural damage in surgically aged mice, which was attributed to the reduced cGAS-STING pathway and M1 microglial polarization by decreased release of mitochondrial DNA (mtDNA) but not nuclear DNA (nDNA).
    1 context sentence
    Summary · context
    Internal fixation of tibial fracture was performed in 18-month-old mice to induce surgery-associated neurocognitive dysfunction.
  6. 06LabIn vitro (cells)Mechanism

    In LPS-stimulated BV2 cells, PHB2 knockdown and an STING agonist abolished the protective effect of SS‑31.

    In plain wordsIn cells, blocking PHB2 or adding an STING agonist removed the protective effect of SS‑31.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableProtective effect of SS-31 after PHB2 knockdown or STING agonist
    Study

    n: not reported in source

    LPS-treated BV2 cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, knockdown of PHB2 and an STING agonist abolished the protective effect of SS-31.
    1 context sentence
    Summary · context
    LPS was administrated to BV2 cells to induce neuroinflammation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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