In Vitro Study of Thymosin Beta 4 Promoting Transplanted Fat Survival by Regulating Adipose-Derived Stem Cells.

Li W, Yang Y, Lin Y, Mu D

Aesthetic plastic surgery26 Feb 2024Cited by 3 (Europe PMC)

PMID38409346DOI10.1007/s00266-024-03861-1PepBankPUB-38409346

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In human adipose-derived stem cells, Tβ4 at 100 ng/mL significantly increased proliferation from day 1 compared with control.
In plain wordsIn lab-grown fat stem cells, Tβ4 increased cell growth more than no Tβ4.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseADSC proliferation at 100 ng/mL
Study
humann: not reported in source
Adipose-derived stem cells (ADSCs) from liposuction patients
Comparator
Control (0 ng/mL)
Outcome group
Wound healing · Skin and wound
Studied dose
100 ng/mLAs given in this study (human).
Measurements
p-value
0.0171
100 ng/mL
Source sentences
Summary
Tβ4 at 100 ng/mL (p-value = 0.0171) and 1000 ng/mL (p-value = 0.0054) significantly increased ADSC proliferation from day 1 compared to the control group (0 ng/mL)
1 context sentence(design, population, supporting numbers)
Summary · context
ADSCs were isolated from patients undergoing liposuction and their proliferation, apoptosis, anti-apoptosis, and migration were analyzed under Tβ4 stimulation using cell counting kit-8, flow cytometry, wound healing assay, and real-time quantitative PCR.
Report a problemFND-3840934601
02LabIn vitro (cells)Efficacy outcome
In human adipose-derived stem cells, Tβ4 at 1000 ng/mL significantly increased proliferation from day 1 compared with control.
In plain wordsIn lab-grown fat stem cells, a higher Tβ4 amount also increased cell growth more than no Tβ4.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseADSC proliferation at 1000 ng/mL
Study
humann: not reported in source
Adipose-derived stem cells (ADSCs) from liposuction patients
Comparator
Control (0 ng/mL)
Outcome group
Wound healing · Skin and wound
Studied dose
1000 ng/mLAs given in this study (human).
Measurements
p-value
0.0054
1000 ng/mL
Source sentences
Summary
Tβ4 at 100 ng/mL (p-value = 0.0171) and 1000 ng/mL (p-value = 0.0054) significantly increased ADSC proliferation from day 1 compared to the control group (0 ng/mL)
1 context sentence(design, population, supporting numbers)
Summary · context
ADSCs were isolated from patients undergoing liposuction and their proliferation, apoptosis, anti-apoptosis, and migration were analyzed under Tβ4 stimulation using cell counting kit-8, flow cytometry, wound healing assay, and real-time quantitative PCR.
Report a problemFND-3840934602
03LabIn vitro (cells)Mechanism
In human adipose-derived stem cells, mRNA levels of proliferation-associated genes were elevated in the Tβ4 group.
In plain wordsIn lab-grown fat stem cells, Tβ4 raised the activity of genes linked to cell growth.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseProliferation-associated gene mRNA levels
Study
humann: not reported in source
Adipose-derived stem cells (ADSCs) from liposuction patients
Comparator
Control (0 ng/mL)
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
In addition, the mRNA levels of proliferation-associated genes were elevated in the Tβ4 group.
1 context sentence(design, population, supporting numbers)
Summary · context
ADSCs were isolated from patients undergoing liposuction and their proliferation, apoptosis, anti-apoptosis, and migration were analyzed under Tβ4 stimulation using cell counting kit-8, flow cytometry, wound healing assay, and real-time quantitative PCR.
Report a problemFND-3840934603
04LabIn vitro (cells)Efficacy outcome
In human adipose-derived stem cells exposed to an apoptotic induction reagent, Tβ4 enhanced anti-apoptotic ability (0 ng/mL versus 1000 ng/mL, p-value = 0.011).
In plain wordsIn lab-grown fat stem cells, Tβ4 made the cells better at resisting induced cell death.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseAnti-apoptotic ability of ADSCs
Study
humann: not reported in source
Adipose-derived stem cells (ADSCs) from liposuction patients
Comparator
Control (0 ng/mL)
Outcome group
Wound healing · Skin and wound
Studied dose
1000 ng/mLAs given in this study (human).
Measurements
p-value
0.011
0 vs 1000 ng/mL
Source sentences
Summary
Furthermore, Tβ4 enhanced the anti-apoptotic ability of ADSCs when stimulated with Tβ4 and an apoptotic induction reagent (0 ng/mL vs. 1000 ng/mL, p-value = 0.011).
1 context sentence(design, population, supporting numbers)
Summary · context
ADSCs were isolated from patients undergoing liposuction and their proliferation, apoptosis, anti-apoptosis, and migration were analyzed under Tβ4 stimulation using cell counting kit-8, flow cytometry, wound healing assay, and real-time quantitative PCR.
Report a problemFND-3840934604
05LabIn vitro (cells)Mechanism
In human adipose-derived stem cells, Tβ4 affected mRNA expression of angiogenesis-related genes.
In plain wordsIn lab-grown fat stem cells, Tβ4 changed the activity of genes linked to blood vessel growth.
Peptide
Thymosin beta-4 (human)
Outcome
Direction not reportedAngiogenesis-related gene mRNA levels
Study
humann: not reported in source
Adipose-derived stem cells (ADSCs) from liposuction patients
Comparator
Control (0 ng/mL)
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
Crucially, the mRNA expression levels of angiogenesis-related genes and critical genes in the Hippo pathway were affected by Tβ4 in ADSCs.
1 context sentence(design, population, supporting numbers)
Summary · context
ADSCs were isolated from patients undergoing liposuction and their proliferation, apoptosis, anti-apoptosis, and migration were analyzed under Tβ4 stimulation using cell counting kit-8, flow cytometry, wound healing assay, and real-time quantitative PCR.
Report a problemFND-3840934605
06LabIn vitro (cells)Mechanism
In human adipose-derived stem cells, Tβ4 affected mRNA expression of critical genes in the Hippo pathway.
In plain wordsIn lab-grown fat stem cells, Tβ4 changed the activity of key Hippo pathway genes.
Peptide
Thymosin beta-4 (human)
Outcome
Direction not reportedHippo pathway gene mRNA levels
Study
humann: not reported in source
Adipose-derived stem cells (ADSCs) from liposuction patients
Comparator
Control (0 ng/mL)
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
Crucially, the mRNA expression levels of angiogenesis-related genes and critical genes in the Hippo pathway were affected by Tβ4 in ADSCs.
1 context sentence(design, population, supporting numbers)
Summary · context
ADSCs were isolated from patients undergoing liposuction and their proliferation, apoptosis, anti-apoptosis, and migration were analyzed under Tβ4 stimulation using cell counting kit-8, flow cytometry, wound healing assay, and real-time quantitative PCR.
Report a problemFND-3840934606

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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In Vitro Study of Thymosin Beta 4 Promoting Transplanted Fat Survival by Regulating Adipose-Derived Stem Cells.

Summary

Results from this study6

Version history

Subjects

Publication types

MeSH terms

Keywords