Skip to content

Study · Animal study (in vivo) · mouse · 2024

7 results

Supplementation of nicotinamide mononucleotide diminishes COX-2 associated inflammatory responses in macrophages by activating kynurenine/AhR signaling.

Liu J, Hou W, Zong Z, Chen Y, Liu X, Zhang R, Deng H

Free radical biology & medicine8 Feb 2024Cited by 6 (Europe PMC)

PMID38336100 (opens in a new tab)DOI10.1016/j.freeradbiomed.2024.01.046 (opens in a new tab)PepBankPUB-38336100
Publisher pagePubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In induced inflammation models, NMN suppressed inflammatory responses in vivo.

    In plain wordsIn mice with induced inflammation, NMN reduced inflammatory responses.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseInflammatory responses
    Study

    mousen: not reported in source

    LPS- and alum-induced inflammation
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the present study, we established LPS- and alum-induced inflammation model and demonstrated that NMN suppressed the inflammatory responses in vivo.
  2. 02LabEx vivo tissueMechanism

    In activated mouse peritoneal macrophages, NMN activated AhR signaling.

    In plain wordsIn lab tests, NMN activated AhR signaling in mouse immune cells.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAhR signaling
    Study

    mousen: not reported in source

    Mouse peritoneal macrophages
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Quantitative proteomics in mouse peritoneal macrophages identified that NMN activated AhR signaling pathway in activated macrophages.
  3. 03LabEx vivo tissueMechanism

    In macrophages, NMN supplementation activated IDO1.

    In plain wordsIn lab tests, NMN activated IDO1 in immune cells.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseIDO1 activation
    Study

    mousen: not reported in source

    Macrophages
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, we revealed that NMN supplementation led to IDO1 activation and kynurenine accumulation, which caused AhR nuclear translocation and activation.
    1 context sentence
    Summary · context
    Quantitative proteomics in mouse peritoneal macrophages identified that NMN activated AhR signaling pathway in activated macrophages.
  4. 04LabEx vivo tissueMechanism

    In macrophages, NMN supplementation increased kynurenine accumulation.

    In plain wordsIn lab tests, NMN increased kynurenine accumulation in immune cells.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseKynurenine accumulation
    Study

    mousen: not reported in source

    Macrophages
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, we revealed that NMN supplementation led to IDO1 activation and kynurenine accumulation, which caused AhR nuclear translocation and activation.
    1 context sentence
    Summary · context
    Quantitative proteomics in mouse peritoneal macrophages identified that NMN activated AhR signaling pathway in activated macrophages.
  5. 05LabEx vivo tissueMechanism

    In macrophages, NMN-induced IDO1 activation and kynurenine accumulation caused AhR nuclear translocation.

    In plain wordsIn lab tests, NMN promoted AhR movement into immune cell nuclei through IDO1 and kynurenine.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAhR nuclear translocation
    Study

    mousen: not reported in source

    Macrophages
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, we revealed that NMN supplementation led to IDO1 activation and kynurenine accumulation, which caused AhR nuclear translocation and activation.

Studies that did not test the peptide alone2

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 06LabNot a test of NMN (nicotinamide mononucleotide) aloneEx vivo tissueMechanism

    In macrophages, AhR or IDO1 knockout abolished NMN suppression of COX-2 expression.

    In plain wordsIn lab tests, removing AhR or IDO1 removed NMN effects on COX-2 expression in immune cells.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableKnockout dependence of COX-2 suppression
    Study

    mousen: not reported in source

    AhR- or IDO1-knockout macrophages
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    On the other hand, AhR or IDO1 knockout abolished the effects of NMN on suppressing COX-2 expression and inflammatory responses in macrophages.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  2. 07LabNot a test of NMN (nicotinamide mononucleotide) aloneEx vivo tissueMechanism

    In macrophages, AhR or IDO1 knockout abolished NMN suppression of inflammatory responses.

    In plain wordsIn lab tests, removing AhR or IDO1 removed NMN effects on inflammatory responses in immune cells.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableKnockout dependence of inflammatory suppression
    Study

    mousen: not reported in source

    AhR- or IDO1-knockout macrophages
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    On the other hand, AhR or IDO1 knockout abolished the effects of NMN on suppressing COX-2 expression and inflammatory responses in macrophages.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.