Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer.

Kavak AG, Karslioglu I, Saracaloglu A, Demiryürek S, Demiryürek AT

Current radiopharmaceuticals1 Jan 2024Cited by 16 (Europe PMC)

PMID38314601DOI10.2174/0118744710254730231114181358PepBankPUB-38314601

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In patients with lung cancer, circulating serum MOTS‑c levels were markedly elevated.
In plain wordsIn people with lung cancer, the body's own MOTS‑c levels in blood were raised.
Peptide
MOTS-c
Outcome
IncreaseCirculating MOTS-c in lung cancer
Study
n = 35
Outcome group
Mitochondrial function · Cancer
Source sentences
Summary
We observed marked elevations in circulating MOTS-c, but not humanin levels in patients with lung cancer (P < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
35 lung cancer patients, 34 breast cancer patients, and healthy volunteers as a control group were recruited in this prospective observatory research.
Summary · context
The ELISA method was used to detect serum humanin and MOTS-c levels during, before, and after radiotherapy.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3831460101
02HumanEndogenous levelObservational studyOther
In patients with lung cancer, radiation therapy was followed by a marked increase in serum MOTS‑c levels.
In plain wordsIn people with lung cancer, radiation therapy was linked to higher levels of the body's own MOTS‑c.
Peptide
MOTS-c
Outcome
IncreaseSerum MOTS-c after radiation therapy in lung cancer
Study
n = 35
Outcome group
Mitochondrial function · Cancer
Source sentences
Summary
Radiation therapy led to a marked augmentation in MOTS-c levels in these patients (P < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
35 lung cancer patients, 34 breast cancer patients, and healthy volunteers as a control group were recruited in this prospective observatory research.
Summary · context
The ELISA method was used to detect serum humanin and MOTS-c levels during, before, and after radiotherapy.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3831460102
03HumanEndogenous levelObservational studyOther
In patients with breast cancer, serum MOTS‑c levels showed no marked change.
In plain wordsIn people with breast cancer, the body's own MOTS‑c levels in blood did not change markedly.
Peptide
MOTS-c
Outcome
No significant changeCirculating MOTS-c in breast cancer
Study
n = 34
Outcome group
Mitochondrial function · Cancer
Source sentences
Summary
On the other hand, there was a marked decline in humanin, but not MOTS-c, levels in breast cancer patients (P < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
35 lung cancer patients, 34 breast cancer patients, and healthy volunteers as a control group were recruited in this prospective observatory research.
Summary · context
The ELISA method was used to detect serum humanin and MOTS-c levels during, before, and after radiotherapy.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3831460103
04HumanEndogenous levelObservational studyOther
In patients with lung cancer, serum humanin was not elevated compared with healthy volunteers.
In plain wordsIn people with lung cancer, the body's own humanin level in blood was not higher than in healthy people.
Peptide
Humanin
Outcome
No significant changeSerum humanin in lung cancer
Study
n: not reported in source
Comparator
Healthy volunteers
Outcome group
Endogenous peptide levels · Cancer
Source sentences
Summary
We observed marked elevations in circulating MOTS-c, but not humanin levels in patients with lung cancer (P < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
35 lung cancer patients, 34 breast cancer patients, and healthy volunteers as a control group were recruited in this prospective observatory research.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3831460104
05HumanEndogenous levelObservational studyOther
In patients with breast cancer, serum humanin was markedly lower than in healthy volunteers.
In plain wordsIn people with breast cancer, the body's own humanin level in blood was lower than in healthy people.
Peptide
Humanin
Outcome
DecreaseSerum humanin in breast cancer
Study
n: not reported in source
Comparator
Healthy volunteers
Outcome group
Endogenous peptide levels · Cancer
Source sentences
Summary
On the other hand, there was a marked decline in humanin, but not MOTS-c, levels in breast cancer patients (P < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
35 lung cancer patients, 34 breast cancer patients, and healthy volunteers as a control group were recruited in this prospective observatory research.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3831460105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 4 to 18Current
28 Oct 2026, 02:02 UTC
The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.
Study results updated
Version 3
13 Oct 2026, 16:31 UTC
Study data updated · source update from Europe PMC
Version 2
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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