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Study · Animal study (in vivo) · mouse · 2024

12 results

Dietary NMN supplementation enhances motor and NMJ function in ALS.

Lundt S, Zhang N, Polo-Parada L, Wang X, Ding S

Experimental neurology22 Jan 2024Cited by 9 (Europe PMC)

PMID38266764 (opens in a new tab)PMCIDPMC12696721 (opens in a new tab)DOI10.1016/j.expneurol.2024.114698 (opens in a new tab)PepBankPUB-38266764
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ALS mice, dietary NMN modestly extended lifespan.

    In plain wordsIn mice with ALS, dietary NMN modestly extended lifespan compared with ALS mice without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseLifespan
    Study

    mousen: not reported in source

    SOD1G93A ALS mice
    Comparator
    ALS mice without NMN
    Outcome group
    Mortality · Nervous system and cognition
    Studied dose
    Dose not stated · dietaryAs given in this study (mouse).

    Source sentences

    Summary
    We found that the ALS mice fed with an NMN-supplemented diet (ALS+NMN mice) had modestly extended lifespan and exhibited delayed motor dysfunction.
    1 context sentence
    Summary · context
    In the current study, we determined whether the supplementation of nicotinamide mononucleotide (NMN), an NAD+ precursor, in the diet had beneficial impacts on disease progression using a SOD1G93A mouse model of ALS.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ALS mice, dietary NMN delayed motor dysfunction.

    In plain wordsIn mice with ALS, dietary NMN delayed motor problems compared with ALS mice without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMotor dysfunction
    Study

    mousen: not reported in source

    SOD1G93A ALS mice
    Comparator
    ALS mice without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · dietaryAs given in this study (mouse).

    Source sentences

    Summary
    We found that the ALS mice fed with an NMN-supplemented diet (ALS+NMN mice) had modestly extended lifespan and exhibited delayed motor dysfunction.
    1 context sentence
    Summary · context
    In the current study, we determined whether the supplementation of nicotinamide mononucleotide (NMN), an NAD+ precursor, in the diet had beneficial impacts on disease progression using a SOD1G93A mouse model of ALS.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ALS mice, dietary NMN increased EPP amplitudes compared with ALS mice without NMN.

    In plain wordsIn mice with ALS, NMN increased EPP amplitudes compared with ALS mice without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseEPP amplitude
    Study

    mousen: not reported in source

    SOD1G93A ALS mice
    Comparator
    ALS mice without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · dietaryAs given in this study (mouse).

    Source sentences

    Summary
    ALS+NMN mice had larger end-plate potential (EPP) amplitudes and maintained better responses than ALS mice, and also had restored EPP facilitation.
    1 context sentence
    Summary · context
    In the current study, we determined whether the supplementation of nicotinamide mononucleotide (NMN), an NAD+ precursor, in the diet had beneficial impacts on disease progression using a SOD1G93A mouse model of ALS.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ALS mice, dietary NMN maintained better NMJ responses than in ALS mice without NMN.

    In plain wordsIn mice with ALS, NMN maintained better neuromuscular responses than in ALS mice without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNMJ responses
    Study

    mousen: not reported in source

    SOD1G93A ALS mice
    Comparator
    ALS mice without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · dietaryAs given in this study (mouse).

    Source sentences

    Summary
    ALS+NMN mice had larger end-plate potential (EPP) amplitudes and maintained better responses than ALS mice, and also had restored EPP facilitation.
    1 context sentence
    Summary · context
    In the current study, we determined whether the supplementation of nicotinamide mononucleotide (NMN), an NAD+ precursor, in the diet had beneficial impacts on disease progression using a SOD1G93A mouse model of ALS.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In ALS mice, dietary NMN restored EPP facilitation.

    In plain wordsIn mice with ALS, NMN restored EPP facilitation compared with ALS mice without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseEPP facilitation
    Study

    mousen: not reported in source

    SOD1G93A ALS mice
    Comparator
    ALS mice without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · dietaryAs given in this study (mouse).

    Source sentences

    Summary
    ALS+NMN mice had larger end-plate potential (EPP) amplitudes and maintained better responses than ALS mice, and also had restored EPP facilitation.
    1 context sentence
    Summary · context
    In the current study, we determined whether the supplementation of nicotinamide mononucleotide (NMN), an NAD+ precursor, in the diet had beneficial impacts on disease progression using a SOD1G93A mouse model of ALS.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In ALS mice, dietary NMN did not affect quantal content.

    In plain wordsIn mice with ALS, NMN did not change quantal content compared with ALS mice without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeQuantal content
    Study

    mousen: not reported in source

    SOD1G93A ALS mice
    Comparator
    ALS mice without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · dietaryAs given in this study (mouse).

    Source sentences

    Summary
    While quantal content was not affected by NMN, miniature EPP (mEPP) amplitude and frequency were elevated in ALS+NMN mice.
    1 context sentence
    Summary · context
    In the current study, we determined whether the supplementation of nicotinamide mononucleotide (NMN), an NAD+ precursor, in the diet had beneficial impacts on disease progression using a SOD1G93A mouse model of ALS.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In ALS mice, dietary NMN increased mEPP amplitude.

    In plain wordsIn mice with ALS, NMN increased mEPP amplitude compared with ALS mice without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasemEPP amplitude
    Study

    mousen: not reported in source

    SOD1G93A ALS mice
    Comparator
    ALS mice without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · dietaryAs given in this study (mouse).

    Source sentences

    Summary
    While quantal content was not affected by NMN, miniature EPP (mEPP) amplitude and frequency were elevated in ALS+NMN mice.
    1 context sentence
    Summary · context
    In the current study, we determined whether the supplementation of nicotinamide mononucleotide (NMN), an NAD+ precursor, in the diet had beneficial impacts on disease progression using a SOD1G93A mouse model of ALS.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In ALS mice, dietary NMN increased mEPP frequency.

    In plain wordsIn mice with ALS, NMN increased mEPP frequency compared with ALS mice without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasemEPP frequency
    Study

    mousen: not reported in source

    SOD1G93A ALS mice
    Comparator
    ALS mice without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · dietaryAs given in this study (mouse).

    Source sentences

    Summary
    While quantal content was not affected by NMN, miniature EPP (mEPP) amplitude and frequency were elevated in ALS+NMN mice.
    1 context sentence
    Summary · context
    In the current study, we determined whether the supplementation of nicotinamide mononucleotide (NMN), an NAD+ precursor, in the diet had beneficial impacts on disease progression using a SOD1G93A mouse model of ALS.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In ALS mice, dietary NMN improved NMJ morphology.

    In plain wordsIn mice with ALS, NMN improved neuromuscular junction structure compared with ALS mice without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNMJ morphology
    Study

    mousen: not reported in source

    SOD1G93A ALS mice
    Comparator
    ALS mice without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · dietaryAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation in diet also improved NMJ morphology, innervation, mitochondrial structure, and reduced reactive astrogliosis in the ventral horn of the lumbar spinal cord.
    1 context sentence
    Summary · context
    In the current study, we determined whether the supplementation of nicotinamide mononucleotide (NMN), an NAD+ precursor, in the diet had beneficial impacts on disease progression using a SOD1G93A mouse model of ALS.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In ALS mice, dietary NMN improved innervation.

    In plain wordsIn mice with ALS, NMN improved nerve connections compared with ALS mice without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseInnervation
    Study

    mousen: not reported in source

    SOD1G93A ALS mice
    Comparator
    ALS mice without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · dietaryAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation in diet also improved NMJ morphology, innervation, mitochondrial structure, and reduced reactive astrogliosis in the ventral horn of the lumbar spinal cord.
    1 context sentence
    Summary · context
    In the current study, we determined whether the supplementation of nicotinamide mononucleotide (NMN), an NAD+ precursor, in the diet had beneficial impacts on disease progression using a SOD1G93A mouse model of ALS.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In ALS mice, dietary NMN improved mitochondrial structure.

    In plain wordsIn mice with ALS, NMN improved mitochondrial structure compared with ALS mice without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMitochondrial structure
    Study

    mousen: not reported in source

    SOD1G93A ALS mice
    Comparator
    ALS mice without NMN
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated · dietaryAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation in diet also improved NMJ morphology, innervation, mitochondrial structure, and reduced reactive astrogliosis in the ventral horn of the lumbar spinal cord.
    1 context sentence
    Summary · context
    In the current study, we determined whether the supplementation of nicotinamide mononucleotide (NMN), an NAD+ precursor, in the diet had beneficial impacts on disease progression using a SOD1G93A mouse model of ALS.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In ALS mice, dietary NMN reduced reactive astrogliosis in the lumbar spinal cord ventral horn.

    In plain wordsIn mice with ALS, NMN reduced spinal cord astrocyte reactivity compared with ALS mice without NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseReactive astrogliosis
    Study

    mousen: not reported in source

    SOD1G93A ALS mice
    Comparator
    ALS mice without NMN
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · dietaryAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation in diet also improved NMJ morphology, innervation, mitochondrial structure, and reduced reactive astrogliosis in the ventral horn of the lumbar spinal cord.
    1 context sentence
    Summary · context
    In the current study, we determined whether the supplementation of nicotinamide mononucleotide (NMN), an NAD+ precursor, in the diet had beneficial impacts on disease progression using a SOD1G93A mouse model of ALS.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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