Impaired Expression of Humanin during Adrenocortical Carcinoma.

Blatkiewicz M, Szyszka M, Olechnowicz A, Kamiński K, Jopek K, Komarowska H, Tyczewska M, Klimont A, Wierzbicki T, Karczewski M, Ruchała M, Rucinski M

International journal of molecular sciences15 Jan 2024Cited by 2 (Europe PMC)

PMID38256114PMCIDPMC10816135DOI10.3390/ijms25021038PepBankPUB-38256114

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Summary

The discovery of mitochondria-derived peptides (MDPs) has provided a new perspective on mitochondrial function. MDPs encoded by mitochondrial DNA (mtDNA) can act as hormone-like peptides, influencing cell survival and proliferation. Among these peptides, humanin has been identified as a crucial factor for maintaining cell survival and preventing cell death under various conditions. Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy that results from adrenal hormone dysfunction. This study aimed to investigate humanin expression in the adrenal tissue and serum of patients with ACC. For the first time, our study revealed significant reduction in the mRNA expression of humanin in patients with ACC compared to healthy controls. However, no significant changes were observed in the serum humanin levels. Interestingly, we identified a positive correlation between patient age and serum humanin levels and a negative correlation between tumor size and LDL levels. While the impaired expression of humanin in patients with ACC may be attributed to mitochondrial dysfunction, an alternative explanation could be related to diminished mitochondrial copy number. Further investigations are warranted to elucidate the intricate relationship among humanin, mitochondrial function, and ACC pathology.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In patients with adrenocortical carcinoma, humanin mRNA expression was significantly lower than in healthy controls.
In plain wordsIn patients with adrenal cancer, the body's own humanin gene activity was lower than in healthy people.
Peptide
Humanin
Outcome
DecreaseHumanin mRNA expression in adrenal tissue
Study
n: not reported in source
Comparator
Healthy controls
Outcome group
Endogenous peptide levels · Cancer
Source sentences
Summary
significant reduction in the mRNA expression of humanin in patients with ACC compared to healthy controls.
1 context sentence(design, population, supporting numbers)
Summary · context
This study aimed to investigate humanin expression in the adrenal tissue and serum of patients with ACC.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-3825611401
02HumanEndogenous levelObservational studyOther
In patients with adrenocortical carcinoma, serum humanin levels did not change significantly.
In plain wordsIn patients with adrenal cancer, natural humanin levels in the blood did not differ significantly from healthy people.
Peptide
Humanin
Outcome
No significant changeSerum humanin level
Study
n: not reported in source
Comparator
Healthy controls
Outcome group
Endogenous peptide levels · Cancer
Source sentences
Summary
However, no significant changes were observed in the serum humanin levels.
1 context sentence(design, population, supporting numbers)
Summary · context
This study aimed to investigate humanin expression in the adrenal tissue and serum of patients with ACC.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-3825611402
03HumanEndogenous levelObservational studyOther
In patients with adrenocortical carcinoma, patient age correlated positively with serum humanin levels.
In plain wordsIn patients with adrenal cancer, older age was linked to higher natural humanin levels in the blood.
Peptide
Humanin
Outcome
IncreaseCorrelation of patient age with serum humanin
Study
n: not reported in source
Outcome group
Endogenous peptide levels · Cancer
Source sentences
Summary
a positive correlation between patient age and serum humanin levels
1 context sentence(design, population, supporting numbers)
Summary · context
This study aimed to investigate humanin expression in the adrenal tissue and serum of patients with ACC.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-3825611403

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Version history

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Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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