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Study · Animal study (in vivo) · pig · 2024

5 results

Novel Role for Cardiolipin as a Target of Therapy to Mitigate Myocardial Injury Caused by Venoarterial Extracorporeal Membrane Oxygenation.

Swain L, Bhave S, Qiao X, Reyelt L, Everett KD, Awata J, Raghav R, Powers SN, Sunagawa G, Natov PS, Mahmoudi E, Warner M and 7 more

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Couper G, Kawabori M, Miyashita S, Aryaputra T, Huggins GS, Chin MT, Kapur NK

Circulation18 Jan 2024Cited by 18 (Europe PMC)

PMID38235580 (opens in a new tab)PMCIDPMC11039383 (opens in a new tab)DOI10.1161/circulationaha.123.065298 (opens in a new tab)PepBankPUB-38235580
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In swine with myocardial ischemia/reperfusion, MTP-131 given before VA-ECMO activation reduced infarct size compared with reperfusion alone.

    In plain wordsIn pigs, MTP-131 given before ECMO started reduced heart-attack damage compared with reperfusion alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseInfarct size
    Study

    pign: not reported in source

    Closed-chest swine model of myocardial ischemia/reperfusion with VA-ECMO
    Comparator
    Reperfusion alone
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Infarct size
    22%
    MTP-131 before VA-ECMO

    Source sentences

    Summary
    Compared with reperfusion alone or VA-ECMO before reperfusion, delivery of MTP-131 before VA-ECMO activation reduced infarct size (22±8%; P=0.03 versus reperfusion alone
    2 context sentences
    Summary · context
    We examined cardiolipin and tafazzin levels in human subjects with heart failure and healthy swine exposed to VA-ECMO and used a swine model of closed-chest myocardial ischemia/reperfusion injury to evaluate the effect of VA-ECMO on cardiolipin expression, myocardial injury, and mitochondrial function.
    Summary · context
    To explore whether cardiolipin depletion by VA-ECMO increases infarct size, we performed left anterior descending artery occlusion for a total of 120 minutes followed by 180 minutes of reperfusion in adult swine in the presence and absence of MTP-131, an amphipathic molecule that interacts with card…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In swine with myocardial ischemia/reperfusion, MTP-131 given before VA-ECMO activation reduced infarct size compared with VA-ECMO alone.

    In plain wordsIn pigs, MTP-131 given before ECMO started reduced heart-attack damage compared with ECMO alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseInfarct size
    Study

    pign: not reported in source

    Closed-chest swine model of myocardial ischemia/reperfusion with VA-ECMO
    Comparator
    VA-ECMO alone
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Infarct size
    22%
    MTP-131 before VA-ECMO

    Source sentences

    Summary
    Compared with reperfusion alone or VA-ECMO before reperfusion, delivery of MTP-131 before VA-ECMO activation reduced infarct size (22±8%; P=0.03 versus reperfusion alone and P<0.001 versus VA-ECMO alone).
    2 context sentences
    Summary · context
    We examined cardiolipin and tafazzin levels in human subjects with heart failure and healthy swine exposed to VA-ECMO and used a swine model of closed-chest myocardial ischemia/reperfusion injury to evaluate the effect of VA-ECMO on cardiolipin expression, myocardial injury, and mitochondrial function.
    Summary · context
    To explore whether cardiolipin depletion by VA-ECMO increases infarct size, we performed left anterior descending artery occlusion for a total of 120 minutes followed by 180 minutes of reperfusion in adult swine in the presence and absence of MTP-131, an amphipathic molecule that interacts with card…
  3. 03AnimalAnimal study (in vivo)Mechanism

    In swine, MTP-131 restored cardiolipin and tafazzin levels in the left ventricle.

    In plain wordsIn pigs, MTP-131 restored levels of cardiolipin and tafazzin in the heart muscle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCardiolipin and tafazzin levels in the left ventricle
    Study

    pign: not reported in source

    Closed-chest swine model of myocardial ischemia/reperfusion with VA-ECMO
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTP-131 restored cardiolipin and tafazzin levels
    2 context sentences
    Summary · context
    We examined cardiolipin and tafazzin levels in human subjects with heart failure and healthy swine exposed to VA-ECMO and used a swine model of closed-chest myocardial ischemia/reperfusion injury to evaluate the effect of VA-ECMO on cardiolipin expression, myocardial injury, and mitochondrial function.
    Summary · context
    To explore whether cardiolipin depletion by VA-ECMO increases infarct size, we performed left anterior descending artery occlusion for a total of 120 minutes followed by 180 minutes of reperfusion in adult swine in the presence and absence of MTP-131, an amphipathic molecule that interacts with card…
  4. 04AnimalAnimal study (in vivo)Mechanism

    In swine, MTP-131 stabilized mitochondrial function in the left ventricle.

    In plain wordsIn pigs, MTP-131 stabilized how well the heart's mitochondria worked.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial function
    Study

    pign: not reported in source

    Closed-chest swine model of myocardial ischemia/reperfusion with VA-ECMO
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTP-131 restored cardiolipin and tafazzin levels, stabilized mitochondrial function, and reduced oxidative stress in the left ventricle.
    2 context sentences
    Summary · context
    We examined cardiolipin and tafazzin levels in human subjects with heart failure and healthy swine exposed to VA-ECMO and used a swine model of closed-chest myocardial ischemia/reperfusion injury to evaluate the effect of VA-ECMO on cardiolipin expression, myocardial injury, and mitochondrial function.
    Summary · context
    To explore whether cardiolipin depletion by VA-ECMO increases infarct size, we performed left anterior descending artery occlusion for a total of 120 minutes followed by 180 minutes of reperfusion in adult swine in the presence and absence of MTP-131, an amphipathic molecule that interacts with card…
  5. 05AnimalAnimal study (in vivo)Mechanism

    In swine, MTP-131 reduced oxidative stress in the left ventricle.

    In plain wordsIn pigs, MTP-131 reduced oxidative stress in the heart muscle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseOxidative stress in the left ventricle
    Study

    pign: not reported in source

    Closed-chest swine model of myocardial ischemia/reperfusion with VA-ECMO
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTP-131 restored cardiolipin and tafazzin levels, stabilized mitochondrial function, and reduced oxidative stress in the left ventricle.
    2 context sentences
    Summary · context
    We examined cardiolipin and tafazzin levels in human subjects with heart failure and healthy swine exposed to VA-ECMO and used a swine model of closed-chest myocardial ischemia/reperfusion injury to evaluate the effect of VA-ECMO on cardiolipin expression, myocardial injury, and mitochondrial function.
    Summary · context
    To explore whether cardiolipin depletion by VA-ECMO increases infarct size, we performed left anterior descending artery occlusion for a total of 120 minutes followed by 180 minutes of reperfusion in adult swine in the presence and absence of MTP-131, an amphipathic molecule that interacts with card…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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