Skip to content

Study · Case report or series · n = 2 · 2024

1 result

Pulmonary aspiration of gastric contents in two patients taking semaglutide for weight loss.

Avraham SA, Hossein J, Somri F, Hawash N, Hochman O

Anaesthesia reports14 Jan 2024Cited by 29 (Europe PMC)

PMID38225986 (opens in a new tab)PMCIDPMC10788311 (opens in a new tab)DOI10.1002/anr3.12278 (opens in a new tab)PepBankPUB-38225986
Download PDFPubMedAsk about this study
Jump to 1 result

Summary

Semaglutide is a new weight loss treatment that has received substantial media attention in recent years. Anaesthetists must be aware of a potentially dangerous side effect of the drug: decreased gastric emptying. This is caused by effects on gastric smooth muscle, mediated by the vagal afferent nerves. This is especially relevant in the peri-operative setting where pulmonary aspiration of gastric contents is a recognised complication. Here, we report two cases of peri-operative regurgitation of gastric contents in patients taking semaglutide. A patient taking semaglutide may have a full stomach despite compliance with routine pre-operative fasting guidelines. We consider how to manage patients receiving glucagon-like peptide-1 agonist therapy in the peri-operative period, including identifying those at high risk of regurgitation. Precautions such as rapid sequence induction and tracheal intubation can be used, but gastric ultrasound may also be useful in the pre-operative environment to help identify patients at high risk of aspiration.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanCase report or seriesSafety outcome

    Two patients taking semaglutide for weight loss had peri-operative regurgitation of gastric contents with pulmonary aspiration.

    In plain wordsTwo people taking semaglutide for weight loss brought up stomach contents during surgery and breathed some into the lungs.

    Peptide
    Semaglutide
    Outcome
    Not applicablePeri-operative regurgitation of gastric contents
    Study

    n = 2

    Outcome group
    Gastrointestinal adverse events · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we report two cases of peri-operative regurgitation of gastric contents in patients taking semaglutide.
    1 context sentence
    Title · context
    Pulmonary aspiration of gastric contents in two patients taking semaglutide for weight loss.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:04 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:06 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.