Skip to content

Study · Animal study (in vivo) · mouse · 2024

7 results

NAD+ supplementation prevents STING-induced senescence in CD8+ T cells by improving mitochondrial homeostasis.

Ye B, Pei Y, Wang L, Meng D, Zhang Y, Zou S, Li H, Liu J, Xie Z, Tian C, Jiang Y, Qiao Y, Gao X, Zhang Y, Ma N

Journal of cellular biochemistry15 Jan 2024Cited by 22 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NMN suppressed senescence.

    In plain wordsIn mice, NMN reduced senescence.

    Outcome
    DecreaseSenescence
    Study

    mousen: not reported in source

    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN treatment also suppresses senescence and neuroinflammation and improves the survival cycle of mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NMN suppressed neuroinflammation.

    In plain wordsIn mice, NMN reduced inflammation in the nervous system.

    Outcome
    DecreaseNeuroinflammation
    Study

    mousen: not reported in source

    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN treatment also suppresses senescence and neuroinflammation and improves the survival cycle of mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NMN improved the survival cycle.

    In plain wordsIn mice, NMN improved survival.

    Outcome
    IncreaseSurvival cycle
    Study

    mousen: not reported in source

    Outcome group
    Mortality · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN treatment also suppresses senescence and neuroinflammation and improves the survival cycle of mice.
  4. 04LabIn vitro (cells)Efficacy outcome

    In senescent T cells, NMN prevented senescence.

    In plain wordsIn cells, NMN prevented T cell senescence.

    Outcome
    DecreaseCellular senescence
    Study

    n: not reported in source

    Senescent T cells
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We further show that boosting intracellular NAD+ levels with nicotinamide mononucleotide (NMN) prevents senescence and SASP by promoting mitophagy.
  5. 05LabIn vitro (cells)Efficacy outcome

    In senescent T cells, NMN prevented the senescence-associated secretory phenotype.

    In plain wordsIn cells, NMN prevented the secretory changes associated with T cell senescence.

    Outcome
    DecreaseSenescence-associated secretory phenotype
    Study

    n: not reported in source

    Senescent T cells
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We further show that boosting intracellular NAD+ levels with nicotinamide mononucleotide (NMN) prevents senescence and SASP by promoting mitophagy.
  6. 06LabIn vitro (cells)Mechanism

    In senescent T cells, NMN promoted mitophagy.

    In plain wordsIn cells, NMN promoted the removal of mitochondria in T cells.

    Outcome
    IncreaseMitophagy
    Study

    n: not reported in source

    Senescent T cells
    Outcome group
    Mitochondrial function · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We further show that boosting intracellular NAD+ levels with nicotinamide mononucleotide (NMN) prevents senescence and SASP by promoting mitophagy.
  7. 07LabIn vitro (cells)Mechanism

    In senescent T cells, NMN increased intracellular NAD+ levels.

    In plain wordsIn cells, NMN increased NAD+ levels inside senescent T cells.

    Outcome
    IncreaseIntracellular NAD+ levels
    Study

    n: not reported in source

    Senescent T cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We further show that boosting intracellular NAD+ levels with nicotinamide mononucleotide (NMN) prevents senescence and SASP by promoting mitophagy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.