Nicotinamide mononucleotide alleviates seizures via modulating SIRT1-PGC-1α mediated mitochondrial fusion and fission.

Cheng Y, Huang P, Zou Q, Tian H, Cheng Q, Ding H

Journal of neurochemistry9 Jan 2024Cited by 11 (Europe PMC)

PMID38194959DOI10.1111/jnc.16041PepBankPUB-38194959

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study16

14 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In PTZ-induced epileptic mice, NMN reduced seizure intensity.
In plain wordsIn mice with induced epilepsy, NMN reduced seizure intensity.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseSeizure intensity
Study
mousen: not reported in source
PTZ-induced epilepsy
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
We found that NMN treatment significantly reduced the seizure intensity of PTZ-induced epileptic mice, improved their learning and memory ability, and enhanced their motor activity and exploration desire.
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495901
02AnimalAnimal study (in vivo)Efficacy outcome
In PTZ-induced epileptic mice, NMN improved learning and memory.
In plain wordsIn mice with induced epilepsy, NMN improved learning and memory.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseLearning and memory
Study
mousen: not reported in source
PTZ-induced epilepsy
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
We found that NMN treatment significantly reduced the seizure intensity of PTZ-induced epileptic mice, improved their learning and memory ability, and enhanced their motor activity and exploration desire.
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495902
03AnimalAnimal study (in vivo)Efficacy outcome
In PTZ-induced epileptic mice, NMN enhanced motor activity.
In plain wordsIn mice with induced epilepsy, NMN increased motor activity.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMotor activity
Study
mousen: not reported in source
PTZ-induced epilepsy
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
We found that NMN treatment significantly reduced the seizure intensity of PTZ-induced epileptic mice, improved their learning and memory ability, and enhanced their motor activity and exploration desire.
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495903
04AnimalAnimal study (in vivo)Efficacy outcome
In PTZ-induced epileptic mice, NMN enhanced exploration desire.
In plain wordsIn mice with induced epilepsy, NMN increased exploration.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseExploration desire
Study
mousen: not reported in source
PTZ-induced epilepsy
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
We found that NMN treatment significantly reduced the seizure intensity of PTZ-induced epileptic mice, improved their learning and memory ability, and enhanced their motor activity and exploration desire.
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495904
05AnimalAnimal study (in vivo)Efficacy outcome
In the in vivo epilepsy model, NMN inhibited neuronal apoptosis.
In plain wordsIn mice with induced epilepsy, NMN reduced nerve cell death.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseNeuronal apoptosis
Study
mousen: not reported in source
PTZ-induced epilepsy
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
At the same time, in vitro and in vivo experiments showed that NMN can inhibit neuronal apoptosis and improve the mitochondrial energy metabolism function of neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495905
06AnimalAnimal study (in vivo)Efficacy outcome
In the in vivo epilepsy model, NMN improved neuronal mitochondrial energy metabolism.
In plain wordsIn mice with induced epilepsy, NMN improved energy metabolism in nerve cell mitochondria.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMitochondrial energy metabolism
Study
mousen: not reported in source
PTZ-induced epilepsy
Outcome group
Mitochondrial function · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
At the same time, in vitro and in vivo experiments showed that NMN can inhibit neuronal apoptosis and improve the mitochondrial energy metabolism function of neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495907
07AnimalOther designMechanism
In epilepsy models, NMN reduced mitochondrial fission protein Drp1 expression.
In plain wordsIn animal and cell epilepsy models, NMN reduced Drp1 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseDrp1 expression
Study
n: not reported in source
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In addition, NMN down-regulated the expression of mitochondrial fission proteins (Drp1 and Fis1) and promoted the expression of mitochondrial fusion proteins (Mfn1 and Mfn2) by activating the SIRT1-PGC-1α pathway, thereby inhibiting PTZ or Mg²⁺-free extracellular solution-induced mitochon…
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495909
08AnimalOther designMechanism
In epilepsy models, NMN reduced mitochondrial fission protein Fis1 expression.
In plain wordsIn animal and cell epilepsy models, NMN reduced Fis1 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseFis1 expression
Study
n: not reported in source
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In addition, NMN down-regulated the expression of mitochondrial fission proteins (Drp1 and Fis1) and promoted the expression of mitochondrial fusion proteins (Mfn1 and Mfn2) by activating the SIRT1-PGC-1α pathway, thereby inhibiting PTZ or Mg²⁺-free extracellular solution-induced mitochon…
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495910
09AnimalOther designMechanism
In epilepsy models, NMN promoted mitochondrial fusion protein Mfn1 expression.
In plain wordsIn animal and cell epilepsy models, NMN increased Mfn1 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMfn1 expression
Study
n: not reported in source
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In addition, NMN down-regulated the expression of mitochondrial fission proteins (Drp1 and Fis1) and promoted the expression of mitochondrial fusion proteins (Mfn1 and Mfn2) by activating the SIRT1-PGC-1α pathway, thereby inhibiting PTZ or Mg²⁺-free extracellular solution-induced mitochon…
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495911
10AnimalOther designMechanism
In epilepsy models, NMN promoted mitochondrial fusion protein Mfn2 expression.
In plain wordsIn animal and cell epilepsy models, NMN increased Mfn2 expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMfn2 expression
Study
n: not reported in source
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In addition, NMN down-regulated the expression of mitochondrial fission proteins (Drp1 and Fis1) and promoted the expression of mitochondrial fusion proteins (Mfn1 and Mfn2) by activating the SIRT1-PGC-1α pathway, thereby inhibiting PTZ or Mg²⁺-free extracellular solution-induced mitochon…
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495912
11AnimalOther designMechanism
In epilepsy models, NMN activated the SIRT1-PGC-1α pathway.
In plain wordsIn animal and cell epilepsy models, NMN activated the SIRT1-PGC-1α pathway.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSIRT1-PGC-1α pathway activation
Study
n: not reported in source
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In addition, NMN down-regulated the expression of mitochondrial fission proteins (Drp1 and Fis1) and promoted the expression of mitochondrial fusion proteins (Mfn1 and Mfn2) by activating the SIRT1-PGC-1α pathway, thereby inhibiting PTZ or Mg²⁺-free extracellular solution-induced mitochon…
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495913
12AnimalOther designEfficacy outcome
In epilepsy models, NMN inhibited oxidative stress induced by PTZ or Mg2+-free solution.
In plain wordsIn animal and cell epilepsy models, NMN reduced induced oxidative stress.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseOxidative stress
Study
n: not reported in source
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In addition, NMN down-regulated the expression of mitochondrial fission proteins (Drp1 and Fis1) and promoted the expression of mitochondrial fusion proteins (Mfn1 and Mfn2) by activating the SIRT1-PGC-1α pathway, thereby inhibiting PTZ or Mg²⁺-free extracellular solution-induced mitochon…
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495914
13LabIn vitro (cells)Efficacy outcome
In the in vitro epilepsy model, NMN inhibited neuronal apoptosis.
In plain wordsIn cells used to model epilepsy, NMN reduced nerve cell death.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseNeuronal apoptosis
Study
n: not reported in source
Mg2+-free-induced neuronal model
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
At the same time, in vitro and in vivo experiments showed that NMN can inhibit neuronal apoptosis and improve the mitochondrial energy metabolism function of neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495906
14LabIn vitro (cells)Efficacy outcome
In the in vitro epilepsy model, NMN improved neuronal mitochondrial energy metabolism.
In plain wordsIn cells used to model epilepsy, NMN improved energy metabolism in nerve cell mitochondria.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMitochondrial energy metabolism
Study
n: not reported in source
Mg2+-free-induced neuronal model
Outcome group
Mitochondrial function · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
At the same time, in vitro and in vivo experiments showed that NMN can inhibit neuronal apoptosis and improve the mitochondrial energy metabolism function of neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
Report a problemFND-3819495908

Studies that did not test the peptide alone2

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

15AnimalNot a test of NMN (nicotinamide mononucleotide) aloneOther designMechanism
In epilepsy models, combined SIRT1 and PGC-1α inhibition eliminated NMN regulation of mitochondrial fusion and fission proteins.
In plain wordsIn animal and cell epilepsy models, combined pathway inhibition removed NMN effects on mitochondrial fusion and fission proteins.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Not applicablePathway dependence of mitochondrial protein regulation
Study
n: not reported in source
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
However, combined intervention of SIRT1 inhibitor, Selisistat, and PGC-1α inhibitor, SR-18292, eliminated the regulatory effect of NMN pre-treatment on mitochondrial fusion and fission proteins and apoptosis-related proteins.
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3819495915
16AnimalNot a test of NMN (nicotinamide mononucleotide) aloneOther designMechanism
In epilepsy models, combined SIRT1 and PGC-1α inhibition eliminated NMN regulation of apoptosis-related proteins.
In plain wordsIn animal and cell epilepsy models, combined pathway inhibition removed NMN effects on proteins related to cell death.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Not applicablePathway dependence of apoptosis protein regulation
Study
n: not reported in source
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
However, combined intervention of SIRT1 inhibitor, Selisistat, and PGC-1α inhibitor, SR-18292, eliminated the regulatory effect of NMN pre-treatment on mitochondrial fusion and fission proteins and apoptosis-related proteins.
1 context sentence(design, population, supporting numbers)
Summary · context
We established a continuous 30-day PTZ (37 mg/kg) intraperitoneal injection-induced epileptic mouse model and a cell model induced by Mg²⁺-free solution incubation to explore the neuroprotective effects of NMN.
In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).
Report a problemFND-3819495916

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

Keywords

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