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Study · Non-randomized trial · n = 11 · 2024

3 results

Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men.

Yamaguchi S, Irie J, Mitsuishi M, Uchino Y, Nakaya H, Takemura R, Inagaki E, Kosugi S, Okano H, Yasui M, Tsubota K, Hayashi K, Yoshino J, Itoh H

Endocrine journal6 Jan 2024Cited by 16 (Europe PMC)

PMID38191197 (opens in a new tab)DOI10.1507/endocrj.ej23-0431 (opens in a new tab)PepBankPUB-38191197
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialSafety outcome

    In healthy middle-aged Japanese men, NMN supplementation was well tolerated.

    In plain wordsIn healthy middle-aged Japanese men, NMN supplementation was well tolerated.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableTolerability
    Study

    n = 11

    Outcome group
    Adverse events · Whole body
    Studied dose
    two 125-mg capsules once daily · oral · 8 weeksAs given in this study (human).

    Source sentences

    Summary
    The 8-week NMN supplementation regimen was well-tolerated;
    2 context sentences
    Summary · context
    An 8-week, single-center, single-arm, open-label clinical trial was conducted.
    Summary · context
    Eleven healthy, middle-aged Japanese men received two 125-mg NMN capsules once daily before breakfast.
  2. 02HumanNon-randomized trialMechanism

    In healthy middle-aged Japanese men, peripheral blood mononuclear cell NAD+ levels increased during NMN administration.

    In plain wordsIn healthy middle-aged Japanese men, NAD+ levels in blood immune cells increased during NMN use.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasePBMC NAD+ levels
    Study

    n = 11

    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    two 125-mg capsules once daily · oral · 8 weeksAs given in this study (human).

    Source sentences

    Summary
    NAD+ levels in peripheral blood mononuclear cells increased over the course of NMN administration.
    2 context sentences
    Summary · context
    An 8-week, single-center, single-arm, open-label clinical trial was conducted.
    Summary · context
    Eleven healthy, middle-aged Japanese men received two 125-mg NMN capsules once daily before breakfast.
  3. 03HumanNon-randomized trialEfficacy outcome

    In men with insulin oversecretion after glucose loading, NMN modestly attenuated postprandial hyperinsulinemia.

    In plain wordsIn men with excess insulin after oral glucose loading, NMN modestly reduced the high insulin response.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreasePostprandial hyperinsulinemia
    Study

    n = 3

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    two 125-mg capsules once daily · oral · 8 weeksAs given in this study (human).

    Source sentences

    Summary
    In participants with insulin oversecretion after oral glucose loading, NMN modestly attenuated postprandial hyperinsulinemia, a risk factor for coronary artery disease (n = 3).
    2 context sentences
    Summary · context
    An 8-week, single-center, single-arm, open-label clinical trial was conducted.
    Summary · context
    Eleven healthy, middle-aged Japanese men received two 125-mg NMN capsules once daily before breakfast.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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