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Study · Animal study (in vivo) · mouse · 2024

16 results

[Gly14]-humanin exerts a protective effect against D-galactose-induced primary ovarian insufficiency in mice.

Huang J, Feng Q, Zou L, Liu Y, Bao M, Xia W, Zhu C

Reproductive biomedicine online6 Aug 2023Cited by 9 (Europe PMC)

PMID38163419 (opens in a new tab)DOI10.1016/j.rbmo.2023.103330 (opens in a new tab)PepBankPUB-38163419
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study16

16 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with D-galactose-induced ovarian insufficiency, HNG at 10 mg/kg improved the abnormal ovarian morphology compared with the D-gal group.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative improved ovary structure compared with untreated mice.

    Peptide
    Humanin
    Outcome
    IncreaseOvarian morphology
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 mg/kg · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Compared with the D-gal group, 10 mg/kg HNG improved the abnormal ovarian morphology and oestrous cycle (P = 0.0036), increased the number of ovarian follicles (P = 0.0016) and litters (P = 0.0127), and increased the levels of oestrogen (P = 0.0043) and AMH (P = 0.0147).
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with D-galactose-induced ovarian insufficiency, HNG at 10 mg/kg improved the abnormal oestrous cycle compared with the D-gal group.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative improved the reproductive cycle compared with untreated mice.

    Peptide
    Humanin
    Outcome
    IncreaseOestrous cycle
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 mg/kg · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Compared with the D-gal group, 10 mg/kg HNG improved the abnormal ovarian morphology and oestrous cycle (P = 0.0036), increased the number of ovarian follicles (P = 0.0016) and litters (P = 0.0127), and increased the levels of oestrogen (P = 0.0043) and AMH (P = 0.0147).
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with D-galactose-induced ovarian insufficiency, HNG at 10 mg/kg increased the number of ovarian follicles compared with the D-gal group.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative increased egg follicle numbers compared with untreated mice.

    Peptide
    Humanin
    Outcome
    IncreaseNumber of ovarian follicles
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 mg/kg · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Compared with the D-gal group, 10 mg/kg HNG improved the abnormal ovarian morphology and oestrous cycle (P = 0.0036), increased the number of ovarian follicles (P = 0.0016) and litters (P = 0.0127), and increased the levels of oestrogen (P = 0.0043) and AMH (P = 0.0147).
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with D-galactose-induced ovarian insufficiency, HNG at 10 mg/kg increased the number of litters compared with the D-gal group.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative increased the number of litters compared with untreated mice.

    Peptide
    Humanin
    Outcome
    IncreaseNumber of litters
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 mg/kg · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Compared with the D-gal group, 10 mg/kg HNG improved the abnormal ovarian morphology and oestrous cycle (P = 0.0036), increased the number of ovarian follicles (P = 0.0016) and litters (P = 0.0127), and increased the levels of oestrogen (P = 0.0043) and AMH (P = 0.0147).
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with D-galactose-induced ovarian insufficiency, HNG at 10 mg/kg increased oestrogen levels compared with the D-gal group.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative raised oestrogen levels compared with untreated mice.

    Peptide
    Humanin
    Outcome
    IncreaseOestrogen level
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 mg/kg · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Compared with the D-gal group, 10 mg/kg HNG improved the abnormal ovarian morphology and oestrous cycle (P = 0.0036), increased the number of ovarian follicles (P = 0.0016) and litters (P = 0.0127), and increased the levels of oestrogen (P = 0.0043) and AMH (P = 0.0147).
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with D-galactose-induced ovarian insufficiency, HNG at 10 mg/kg increased AMH levels compared with the D-gal group.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative raised AMH levels compared with untreated mice.

    Peptide
    Humanin
    Outcome
    IncreaseAMH level
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 mg/kg · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Compared with the D-gal group, 10 mg/kg HNG improved the abnormal ovarian morphology and oestrous cycle (P = 0.0036), increased the number of ovarian follicles (P = 0.0016) and litters (P = 0.0127), and increased the levels of oestrogen (P = 0.0043) and AMH (P = 0.0147).
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with D-galactose-induced ovarian insufficiency, HNG increased total antioxidant capacity in the ovaries and serum.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative increased antioxidant capacity in the ovaries and blood.

    Peptide
    Humanin
    Outcome
    IncreaseTotal antioxidant capacity in ovary and serum
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Antioxidant indicators in the ovaries and serum of mice, including total antioxidant capacity (P = 0.0004 and P = 0.0032, respectively), catalase (P = 0.0173 and P = 0.0103, respectively) and glutathione (both P < 0.0001) were significantly increased.
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with D-galactose-induced ovarian insufficiency, HNG increased catalase in the ovaries and serum.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative increased an antioxidant enzyme in the ovaries and blood.

    Peptide
    Humanin
    Outcome
    IncreaseCatalase in ovary and serum
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Antioxidant indicators in the ovaries and serum of mice, including total antioxidant capacity (P = 0.0004 and P = 0.0032, respectively), catalase (P = 0.0173 and P = 0.0103, respectively) and glutathione (both P < 0.0001) were significantly increased.
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice with D-galactose-induced ovarian insufficiency, HNG increased glutathione in the ovaries and serum.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative increased an antioxidant in the ovaries and blood.

    Peptide
    Humanin
    Outcome
    IncreaseGlutathione in ovary and serum
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Antioxidant indicators in the ovaries and serum of mice, including total antioxidant capacity (P = 0.0004 and P = 0.0032, respectively), catalase (P = 0.0173 and P = 0.0103, respectively) and glutathione (both P < 0.0001) were significantly increased.
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In mice with D-galactose-induced ovarian insufficiency, HNG decreased the oxidation indicator malondialdehyde.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative lowered a marker of oxidative damage.

    Peptide
    Humanin
    Outcome
    DecreaseMalondialdehyde (oxidation indicator)
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The oxidation indicator malondialdehyde decreased significantly (all P < 0.01).
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In mice with D-galactose-induced ovarian insufficiency, HNG reduced apoptosis of ovarian granulosa cells.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative reduced cell death in ovarian support cells.

    Peptide
    Humanin
    Outcome
    DecreaseApoptosis of ovarian granulosa cells
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Apoptosis of ovarian granulosa cells was significantly reduced (P = 0.0140)
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In mice with D-galactose-induced ovarian insufficiency, HNG reduced expression of the senescence-related protein p53.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative lowered a cell-aging protein.

    Peptide
    Humanin
    Outcome
    Decreasep53 expression
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Aging markers · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    as was the expression of senescence-related proteins p53, p21 and p16 (all P < 0.01).
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In mice with D-galactose-induced ovarian insufficiency, HNG reduced expression of the senescence-related protein p21.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative lowered a cell-aging protein.

    Peptide
    Humanin
    Outcome
    Decreasep21 expression
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Aging markers · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    as was the expression of senescence-related proteins p53, p21 and p16 (all P < 0.01).
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In mice with D-galactose-induced ovarian insufficiency, HNG reduced expression of the senescence-related protein p16.

    In plain wordsIn mice with induced ovarian insufficiency, a humanin derivative lowered a cell-aging protein.

    Peptide
    Humanin
    Outcome
    Decreasep16 expression
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Aging markers · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    as was the expression of senescence-related proteins p53, p21 and p16 (all P < 0.01).
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  15. 15AnimalAnimal study (in vivo)Mechanism

    In mice with D-galactose-induced ovarian insufficiency, the high dose of HNG increased LC3 protein in ovarian tissue.

    In plain wordsIn mice with induced ovarian insufficiency, a high dose of a humanin derivative raised an autophagy marker in the ovaries.

    Peptide
    Humanin
    Outcome
    IncreaseLC3 protein in ovarian tissue (autophagy)
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    high dose · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The level of autophagy in ovarian tissue of mice treated with high increased (significantly increased LC3 protein [P < 0.0001] and significantly reduced p62 protein [P = 0.0007]).
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.
  16. 16AnimalAnimal study (in vivo)Mechanism

    In mice with D-galactose-induced ovarian insufficiency, the high dose of HNG reduced p62 protein in ovarian tissue.

    In plain wordsIn mice with induced ovarian insufficiency, a high dose of a humanin derivative lowered an autophagy marker in the ovaries.

    Peptide
    Humanin
    Outcome
    Decreasep62 protein in ovarian tissue (autophagy)
    Study

    mousen: not reported in source

    D-galactose-induced primary ovarian insufficiency
    Comparator
    D-gal group
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    high dose · intraperitoneal · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The level of autophagy in ovarian tissue of mice treated with high increased (significantly increased LC3 protein [P < 0.0001] and significantly reduced p62 protein [P = 0.0007]).
    2 context sentences
    Summary · context
    D-gal (200 mg/kg/day) was injected subcutaneously for 6 weeks to induce the mouse POI model.
    Summary · context
    Mice treated with HNG were injected intraperitoneally with different concentrations for 6 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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