Alterations in circulating mitochondrial signals at hospital admission for COPD exacerbation.

In patients admitted for COPD exacerbation, serum levels of the body's own MOTS‑c were lower than in patients with stable COPD.

In plain wordsIn people admitted with a COPD flare-up, the body's own MOTS‑c levels were lower than in people with stable COPD.

Source sentences

Serum MOTS‑c had good diagnostic power for COPD exacerbation (AUC 0.744), similar to C-reactive protein.

In plain wordsThe body's own MOTS‑c level helped identify COPD flare-ups, with accuracy similar to the standard marker C-reactive protein.

Measurements

AUC

0.744

MOTS-c for ECOPD

Source sentences

Serum humanin levels did not differ between patients with COPD exacerbation and patients with stable COPD.

In plain wordsThe body's own humanin levels were similar in people with a COPD flare-up and in people with stable COPD.

Source sentences

Humanin levels did not differentiate patients with COPD exacerbation from patients with stable COPD.

In plain wordsThe body's own humanin levels could not tell a COPD flare-up from stable COPD.

Source sentences

In patients admitted for COPD exacerbation, MOTS‑c levels above the mean were an independent risk factor for re-admission (HR 3.441).

In plain wordsIn people admitted with a COPD flare-up, higher body's own MOTS‑c levels were linked to a higher chance of returning to hospital.

Measurements

HR

3.441

MOTS-c above mean, re-admission

Source sentences

In patients admitted for COPD exacerbation, humanin levels above the mean were an independent risk factor for re-admission.

In plain wordsIn people admitted for a COPD flare-up, higher natural humanin levels were linked to a higher risk of later re-admission.

Measurements

Hazard ratio

2.661

humanin above mean level

95% CI

1.009 to 7.016

hazard ratio for re-admission

Source sentences