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Study · Observational study · n = 36 · 2024

6 results

Back to the Future: Is GnRHa Treatment in Transgender and Gender Diverse Adolescents Only an Extended Evaluation Phase?

Fisher AD, Ristori J, Romani A, Cassioli E, Mazzoli F, Cocchetti C, Pierdominici M, Marconi M, Ricca V, Maggi M, Vignozzi L, Castellini G

The Journal of clinical endocrinology and metabolism1 May 2024Cited by 18 (Europe PMC)

PMID38099569 (opens in a new tab)DOI10.1210/clinem/dgad729 (opens in a new tab)PepBankPUB-38099569
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanObservational studyEfficacy outcome

    In transgender and gender diverse adolescents, triptorelin treatment was associated with inhibition of puberty progression.

    In plain wordsIn transgender and gender diverse adolescents, triptorelin treatment was linked to inhibition of puberty progression.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreasePuberty progression
    Study

    n = 36

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · intramuscular · 3 up to 12 monthsAs given in this study (human).

    Source sentences

    Summary
    (1) GnRHa showed efficacy in inhibiting puberty progression in TGDAs;
    2 context sentences
    Summary · context
    This prospective multidisciplinary study included 36 TGDA (22 assigned female at birth, and 14 assigned male at birth) who received psychological assessment followed by triptorelin prescription after referring to the Florence Gender Clinic.
    Summary · context
    This study consisted of 3 time points: first referral (T0), psychological assessment (T1); and treatment with intramuscular injections of triptorelin for 3 up to 12 months (T2).
  2. 02HumanObservational studyEfficacy outcome

    In transgender and gender diverse adolescents, psychological functioning improved during triptorelin treatment.

    In plain wordsIn transgender and gender diverse adolescents, psychological functioning improved during triptorelin treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreasePsychological functioning
    Study

    n = 36

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intramuscular · 3 up to 12 monthsAs given in this study (human).

    Source sentences

    Summary
    (3) during GnRHa treatment (T2), a significant improvement in psychological functioning, as well as decrease in suicidality, body uneasiness, depression, and anxiety levels were observed;
    2 context sentences
    Summary · context
    This prospective multidisciplinary study included 36 TGDA (22 assigned female at birth, and 14 assigned male at birth) who received psychological assessment followed by triptorelin prescription after referring to the Florence Gender Clinic.
    Summary · context
    This study consisted of 3 time points: first referral (T0), psychological assessment (T1); and treatment with intramuscular injections of triptorelin for 3 up to 12 months (T2).
  3. 03HumanObservational studyEfficacy outcome

    In transgender and gender diverse adolescents, suicidality decreased during triptorelin treatment.

    In plain wordsIn transgender and gender diverse adolescents, suicidality decreased during triptorelin treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseSuicidality
    Study

    n = 36

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intramuscular · 3 up to 12 monthsAs given in this study (human).

    Source sentences

    Summary
    (3) during GnRHa treatment (T2), a significant improvement in psychological functioning, as well as decrease in suicidality, body uneasiness, depression, and anxiety levels were observed;
    2 context sentences
    Summary · context
    This prospective multidisciplinary study included 36 TGDA (22 assigned female at birth, and 14 assigned male at birth) who received psychological assessment followed by triptorelin prescription after referring to the Florence Gender Clinic.
    Summary · context
    This study consisted of 3 time points: first referral (T0), psychological assessment (T1); and treatment with intramuscular injections of triptorelin for 3 up to 12 months (T2).
  4. 04HumanObservational studyEfficacy outcome

    In transgender and gender diverse adolescents, body uneasiness decreased during triptorelin treatment.

    In plain wordsIn transgender and gender diverse adolescents, body uneasiness decreased during triptorelin treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseBody uneasiness
    Study

    n = 36

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intramuscular · 3 up to 12 monthsAs given in this study (human).

    Source sentences

    Summary
    (3) during GnRHa treatment (T2), a significant improvement in psychological functioning, as well as decrease in suicidality, body uneasiness, depression, and anxiety levels were observed;
    2 context sentences
    Summary · context
    This prospective multidisciplinary study included 36 TGDA (22 assigned female at birth, and 14 assigned male at birth) who received psychological assessment followed by triptorelin prescription after referring to the Florence Gender Clinic.
    Summary · context
    This study consisted of 3 time points: first referral (T0), psychological assessment (T1); and treatment with intramuscular injections of triptorelin for 3 up to 12 months (T2).
  5. 05HumanObservational studyEfficacy outcome

    In transgender and gender diverse adolescents, depression decreased during triptorelin treatment.

    In plain wordsIn transgender and gender diverse adolescents, depression decreased during triptorelin treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseDepression
    Study

    n = 36

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intramuscular · 3 up to 12 monthsAs given in this study (human).

    Source sentences

    Summary
    (3) during GnRHa treatment (T2), a significant improvement in psychological functioning, as well as decrease in suicidality, body uneasiness, depression, and anxiety levels were observed;
    2 context sentences
    Summary · context
    This prospective multidisciplinary study included 36 TGDA (22 assigned female at birth, and 14 assigned male at birth) who received psychological assessment followed by triptorelin prescription after referring to the Florence Gender Clinic.
    Summary · context
    This study consisted of 3 time points: first referral (T0), psychological assessment (T1); and treatment with intramuscular injections of triptorelin for 3 up to 12 months (T2).
  6. 06HumanObservational studyEfficacy outcome

    In transgender and gender diverse adolescents, anxiety decreased during triptorelin treatment.

    In plain wordsIn transgender and gender diverse adolescents, anxiety decreased during triptorelin treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseAnxiety
    Study

    n = 36

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intramuscular · 3 up to 12 monthsAs given in this study (human).

    Source sentences

    Summary
    (3) during GnRHa treatment (T2), a significant improvement in psychological functioning, as well as decrease in suicidality, body uneasiness, depression, and anxiety levels were observed;
    2 context sentences
    Summary · context
    This prospective multidisciplinary study included 36 TGDA (22 assigned female at birth, and 14 assigned male at birth) who received psychological assessment followed by triptorelin prescription after referring to the Florence Gender Clinic.
    Summary · context
    This study consisted of 3 time points: first referral (T0), psychological assessment (T1); and treatment with intramuscular injections of triptorelin for 3 up to 12 months (T2).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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