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Study · Animal study (in vivo) · rat · 2023

2 results

Carnosine supplementation and retinal oxidative parameters in a high-calorie diet rat model.

de Almeida Torres RJ, Moreto F, Luchini A, de Almeida Torres RJ, Longo SP, Pinho RA, Nagashima S, de Noronha L, Ferron AJT, de Almeida Silva CCV, Correa CR, Aldini G, Ferreira ALA

BMC ophthalmology8 Dec 2023Cited by 2 (Europe PMC)

PMID38066465 (opens in a new tab)PMCIDPMC10709828 (opens in a new tab)DOI10.1186/s12886-023-03255-y (opens in a new tab)PepBankPUB-38066465
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Summary

BackgroundTo assess oxidative effects induced by a high-calorie diet on the retina of Wistar rats and test the antioxidative effects of carnosine supplementation.MethodsWistar rats were randomly divided into the following groups: standard diet (SD), high-calorie diet (HcD), standard diet + carnosine (SD + Car), and high-calorie diet + carnosine (HcD + Car). The body weight, adiposity index, plasma glucose, total lipids, high-density lipoprotein (HDL), low-density lipoprotein (LDL), uric acid, creatinine, and triglycerides of the animals were evaluated. The retinas were analyzed for markers of oxidative stress. Hydrogen peroxide production was assessed by 2',7'-dichlorodihydrofluorescein diacetate (DCF) oxidation. The total glutathione (tGSH), total antioxidant capacity (TAC), protein carbonyl, and sulfhydryl groups of the antioxidant system were analyzed.ResultsTAC levels increased in the retinas of the SD + Car group compared to the SD group (p < 0.05) and in the HcD + Car group compared to the HcD group (p < 0.05). The levels of GSH and the GSSH:GSSG ratio were increased in the HcD + Car group compared to the SD + Car group (p < 0.05). An increase in the retinal carbonyl content was observed in the HcD group compared to the SD group (p < 0.05) and in the HcD + Car group compared to the SD + Car group (p < 0.05). A high-calorie diet (HcD) was also associated with a decrease in retinal sulfhydryl-type levels compared to the SD group (p < 0.05).ConclusionThe results suggest that feeding a high-calorie diet to rats can promote an increase in carbonyl content and a reduction in sulfhydryl groups in their retinas. The administration of carnosine was not effective in attenuating these oxidative markers.Trial registrationAnimal Ethics Committee of Botucatu Medical School - Certificate number 1292/2019.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats on a standard diet, carnosine increased retinal total antioxidant capacity versus standard diet alone.

    In plain wordsIn rats on a standard diet, carnosine increased retinal total antioxidant capacity versus standard diet alone.

    Peptide
    L-carnosine
    Outcome
    IncreaseRetinal TAC with standard diet
    Study

    ratn: not reported in source

    Wistar rat retina
    Comparator
    Standard diet without carnosine
    Outcome group
    Oxidative stress · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TAC levels increased in the retinas of the SD + Car group compared to the SD group (p < 0.05) and in the HcD + Car group compared to the HcD group (p < 0.05).
    2 context sentences
    Summary · context
    To assess oxidative effects induced by a high-calorie diet on the retina of Wistar rats and test the antioxidative effects of carnosine supplementation.
    Summary · context
    Wistar rats were randomly divided into the following groups: standard diet (SD), high-calorie diet (HcD), standard diet + carnosine (SD + Car), and high-calorie diet + carnosine (HcD + Car).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats on a high-calorie diet, carnosine increased retinal total antioxidant capacity versus high-calorie diet alone.

    In plain wordsIn rats on a high-calorie diet, carnosine increased retinal total antioxidant capacity versus high-calorie diet alone.

    Peptide
    L-carnosine
    Outcome
    IncreaseRetinal TAC with high-calorie diet
    Study

    ratn: not reported in source

    Wistar rat retina
    Comparator
    High-calorie diet without carnosine
    Outcome group
    Oxidative stress · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TAC levels increased in the retinas of the SD + Car group compared to the SD group (p < 0.05) and in the HcD + Car group compared to the HcD group (p < 0.05).
    2 context sentences
    Summary · context
    To assess oxidative effects induced by a high-calorie diet on the retina of Wistar rats and test the antioxidative effects of carnosine supplementation.
    Summary · context
    Wistar rats were randomly divided into the following groups: standard diet (SD), high-calorie diet (HcD), standard diet + carnosine (SD + Car), and high-calorie diet + carnosine (HcD + Car).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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