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Study · Animal study (in vivo) · mouse · 2024

6 results

Nicotinamide mononucleotide attenuates airway epithelial barrier dysfunction via inhibiting SIRT3 SUMOylation in asthma.

Liang J, Zhou C, Zhang C, Liang S, Zhou Z, Zhou Z, Wu C, Zhao H, Meng X, Zou F, Yu C, Cai S

International immunopharmacology7 Dec 2023Cited by 12 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In asthmatic mice, NMN alleviated airway inflammation.

    In plain wordsIn mice with dust mite-induced asthma, NMN reduced airway inflammation.

    Outcome
    DecreaseAirway inflammation
    Study

    mousen: not reported in source

    HDM-induced asthma
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this research, NMN alleviated airway inflammation and reduced mucus secretion in house dust mite (HDM)-induced asthmatic mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In asthmatic mice, NMN reduced mucus secretion.

    In plain wordsIn mice with dust mite-induced asthma, NMN reduced mucus secretion.

    Outcome
    DecreaseMucus secretion
    Study

    mousen: not reported in source

    HDM-induced asthma
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this research, NMN alleviated airway inflammation and reduced mucus secretion in house dust mite (HDM)-induced asthmatic mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In the in vivo HDM asthma model, NMN mitigated airway epithelial barrier disruption.

    In plain wordsIn mice with dust mite-induced asthma, NMN reduced airway barrier damage.

    Outcome
    DecreaseAirway epithelial barrier disruption
    Study

    mousen: not reported in source

    HDM-induced asthma
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It also mitigated airway epithelial barrier disruption in HDM-induced asthma in vitro and in vivo.
    1 context sentence
    Summary · context
    In this research, NMN alleviated airway inflammation and reduced mucus secretion in house dust mite (HDM)-induced asthmatic mice.
  4. 04AnimalOther designMechanism

    In HDM-induced models, NMN reversed the decrease in SENP1 expression.

    In plain wordsIn animal and cell dust mite models, NMN reversed the decrease in SENP1 expression.

    Outcome
    IncreaseSENP1 expression
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    And down-regulation of SENP1 expression in HDM-induced models was reversed by NMN.
  5. 05LabIn vitro (cells)Efficacy outcome

    In the in vitro HDM asthma model, NMN mitigated airway epithelial barrier disruption.

    In plain wordsIn lab tests with a dust mite asthma model, NMN reduced airway barrier damage.

    Outcome
    DecreaseAirway epithelial barrier disruption
    Study

    n: not reported in source

    In vitro HDM-induced asthma model
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It also mitigated airway epithelial barrier disruption in HDM-induced asthma in vitro and in vivo.

Studies that did not test the peptide alone1

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 06AnimalNot a test of NMN (nicotinamide mononucleotide) aloneOther designMechanism

    In HDM-induced asthma models, inhibition of SIRT3 expression abolished NMN effects.

    In plain wordsIn animal and cell asthma models, inhibiting SIRT3 expression removed NMN effects.

    Outcome
    Not applicableSIRT3 dependence of NMN effects
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    But inhibition of SIRT3 expression abolished the effects of NMN.
    1 context sentence
    Summary · context
    It also mitigated airway epithelial barrier disruption in HDM-induced asthma in vitro and in vivo.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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