S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice.

Zhao Q, Cai MM, Li D, Zhao BY, Zhou SS, Wu ZR, Shi YJ, Su L

Heliyon8 Nov 2023Cited by 7 (Europe PMC)

PMID38045183PMCIDPMC10692773DOI10.1016/j.heliyon.2023.e21892PepBankPUB-38045183

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In mice with heart failure, the humanin analog HNG delayed the onset of cardiac dysfunction.
In plain wordsIn mice with heart failure, a humanin analog delayed the start of heart dysfunction.
Peptide
Humanin
Outcome
DecreaseOnset of cardiac dysfunction
Study
mousen: not reported in source
Isoproterenol and transverse aortic constriction heart failure models
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
Our results revealed that HNG treatment significantly delayed the onset of cardiac dysfunction and structural remodeling in the HF mouse model.
1 context sentence(design, population, supporting numbers)
Summary · context
HF was induced in mice through intraperitoneal injection of isoproterenol or transverse aortic constriction, followed by separate administration of HNG to assess its therapeutic impact.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3804518301
02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In mice with heart failure, the humanin analog HNG delayed the onset of structural cardiac remodeling.
In plain wordsIn mice with heart failure, a humanin analog delayed changes in the shape of the heart.
Peptide
Humanin
Outcome
DecreaseOnset of structural remodeling
Study
mousen: not reported in source
Isoproterenol and transverse aortic constriction heart failure models
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
Our results revealed that HNG treatment significantly delayed the onset of cardiac dysfunction and structural remodeling in the HF mouse model.
1 context sentence(design, population, supporting numbers)
Summary · context
HF was induced in mice through intraperitoneal injection of isoproterenol or transverse aortic constriction, followed by separate administration of HNG to assess its therapeutic impact.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3804518302
03AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In mice with heart failure, HNG administration was associated with reduced infiltration of inflammatory cells in cardiac tissue.
In plain wordsIn mice with heart failure, a humanin analog was linked to fewer inflammatory cells in the heart.
Peptide
Humanin
Outcome
DecreaseInflammatory cell infiltration in cardiac tissue
Study
mousen: not reported in source
Isoproterenol and transverse aortic constriction heart failure models
Outcome group
Inflammation markers · Cardiovascular
Source sentences
Summary
Furthermore, HNG administration was associated with reduced infiltration of inflammatory cells, improved myocardial fibrosis, and attenuation of cardiomyocyte apoptosis in the treated cardiac tissues.
1 context sentence(design, population, supporting numbers)
Summary · context
HF was induced in mice through intraperitoneal injection of isoproterenol or transverse aortic constriction, followed by separate administration of HNG to assess its therapeutic impact.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3804518303
04AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In mice with heart failure, HNG administration was associated with improved myocardial fibrosis.
In plain wordsIn mice with heart failure, a humanin analog was linked to less scarring of the heart muscle.
Peptide
Humanin
Outcome
DecreaseMyocardial fibrosis
Study
mousen: not reported in source
Isoproterenol and transverse aortic constriction heart failure models
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
Furthermore, HNG administration was associated with reduced infiltration of inflammatory cells, improved myocardial fibrosis, and attenuation of cardiomyocyte apoptosis in the treated cardiac tissues.
1 context sentence(design, population, supporting numbers)
Summary · context
HF was induced in mice through intraperitoneal injection of isoproterenol or transverse aortic constriction, followed by separate administration of HNG to assess its therapeutic impact.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3804518304
05AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In mice with heart failure, HNG administration was associated with attenuated cardiomyocyte apoptosis.
In plain wordsIn mice with heart failure, a humanin analog was linked to less heart cell death.
Peptide
Humanin
Outcome
DecreaseCardiomyocyte apoptosis
Study
mousen: not reported in source
Isoproterenol and transverse aortic constriction heart failure models
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
Furthermore, HNG administration was associated with reduced infiltration of inflammatory cells, improved myocardial fibrosis, and attenuation of cardiomyocyte apoptosis in the treated cardiac tissues.
1 context sentence(design, population, supporting numbers)
Summary · context
HF was induced in mice through intraperitoneal injection of isoproterenol or transverse aortic constriction, followed by separate administration of HNG to assess its therapeutic impact.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3804518305
06AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism
In isoproterenol-induced heart failure in mice, the transforming growth factor-beta pathway was involved in the effects of HNG.
In plain wordsIn mice with heart failure, a humanin analog acted partly through the TGF-beta pathway.
Peptide
Humanin
Outcome
Not applicableTGF-beta signaling pathway involvement
Study
mousen: not reported in source
Isoproterenol and transverse aortic constriction heart failure models
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Additionally, we identified the involvement of the transforming growth factor-beta signaling pathway in the beneficial effects of HNG in isoproterenol-induced HF mice.
1 context sentence(design, population, supporting numbers)
Summary · context
HF was induced in mice through intraperitoneal injection of isoproterenol or transverse aortic constriction, followed by separate administration of HNG to assess its therapeutic impact.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3804518306

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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