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Study · Measured the body's own peptide · 2023

2 results

Proteomic analysis of salivary inflammatory biomarkers of developmental gingival enlargements in patients with West and Noonan syndromes: a preliminary pilot single-center retrospective study.

Guglielmi F, Kirschner F, Staderini E, Iavarone F, Fiorino A, Gallenzi P

European review for medical and pharmacological sciences1 Nov 2023Cited by 5 (Europe PMC)

PMID38039040 (opens in a new tab)DOI10.26355/eurrev_202311_34478 (opens in a new tab)PepBankPUB-38039040
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In children with Noonan syndrome, salivary thymosin β4 differed significantly from the other groups and was overexpressed.

    In plain wordsIn children with Noonan syndrome, the body's own thymosin β4 in saliva was higher than in the other groups.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSalivary thymosin β4 in Noonan syndrome
    Study

    n: not reported in source

    Comparator
    West syndrome and healthy control groups
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    thymosin β4 (p=0.025) in the Noonan syndrome.
    3 context sentences
    Summary · context
    Proteomic analysis revealed an overexpression of peptides related to the innate (thymosin β4) and acquired (defensin α1, α3) immunity.
    Summary · context
    The aim of the preliminary pilot single-center retrospective cross-sectional study was to analyze and compare the presence of non-secretory salivary inflammatory biomarkers in pediatric patients with West syndrome, Noonan syndrome, and a healthy control group.
    Summary · context
    A total of 60 saliva samples were collected during dental check-ups.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In children with West syndrome, only defensin α1 differed significantly from the other groups, so no significant difference in thymosin β4 was reported.

    In plain wordsIn children with West syndrome, the body's own thymosin β4 in saliva did not differ significantly from the other groups.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeSalivary thymosin β4 in West syndrome
    Study

    n: not reported in source

    Comparator
    Noonan syndrome and healthy control groups
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    In the West syndrome, only the defensin α1 had a statistically significant difference with the other groups (p=0.022).
    2 context sentences
    Summary · context
    The aim of the preliminary pilot single-center retrospective cross-sectional study was to analyze and compare the presence of non-secretory salivary inflammatory biomarkers in pediatric patients with West syndrome, Noonan syndrome, and a healthy control group.
    Summary · context
    A total of 60 saliva samples were collected during dental check-ups.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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