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Study · Animal study (in vivo) · mouse · 2024

5 results

Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice.

Xu J, Chen X, Liu S, Wei Z, Xu M, Jiang L, Han X, Peng L, Gu X, Xia T

Behavioural brain research4 Nov 2023Cited by 5 (Europe PMC)

PMID37931707 (opens in a new tab)DOI10.1016/j.bbr.2023.114738 (opens in a new tab)PepBankPUB-37931707
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In POCD mice, NMN pretreatment reduced cognitive impairment.

    In plain wordsIn mice with anesthesia-induced cognitive impairment, NMN pretreatment reduced cognitive problems.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseCognitive impairment
    Study

    mousen: not reported in source

    Isoflurane-induced POCD in C57BL/6 J mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 7 days before anesthesiaAs given in this study (mouse).

    Source sentences

    Summary
    And NMN supplementation could effectively prevent the decline of NAD+ and related proteins, and reduce oxidative stress and cognitive disorders after POCD.
    2 context sentences
    Summary · context
    The animal model of POCD was established in C57BL/6 J mice through 6 h isoflurane anesthesia-induced cognitive impairment.
    Summary · context
    Mice were intraperitoneally injected with NMN for 7 days prior to anesthesia, after which oxidative stress and cognitive function were assessed.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In POCD mice, NMN pretreatment reduced oxidative stress.

    In plain wordsIn mice with anesthesia-induced cognitive impairment, NMN pretreatment reduced oxidative stress.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOxidative stress
    Study

    mousen: not reported in source

    Isoflurane-induced POCD in C57BL/6 J mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 7 days before anesthesiaAs given in this study (mouse).

    Source sentences

    Summary
    And NMN supplementation could effectively prevent the decline of NAD+ and related proteins, and reduce oxidative stress and cognitive disorders after POCD.
    2 context sentences
    Summary · context
    The animal model of POCD was established in C57BL/6 J mice through 6 h isoflurane anesthesia-induced cognitive impairment.
    Summary · context
    Mice were intraperitoneally injected with NMN for 7 days prior to anesthesia, after which oxidative stress and cognitive function were assessed.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In POCD mice, NMN prevented the decline in hippocampal NAD+ levels.

    In plain wordsIn mice with anesthesia-induced cognitive impairment, NMN prevented a decline in brain NAD+ levels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseHippocampal NAD+ levels
    Study

    mousen: not reported in source

    Isoflurane-induced POCD in C57BL/6 J mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 7 days before anesthesiaAs given in this study (mouse).

    Source sentences

    Summary
    And NMN supplementation could effectively prevent the decline of NAD+ and related proteins, and reduce oxidative stress and cognitive disorders after POCD.
    3 context sentences
    Summary · context
    Our results showed that cognitive impairment and increased oxidative stress were observed in POCD mice, as well as downregulation of NAD+ levels and related protein expressions of SIRT1 and nicotinamide phosphoribosyltransferase (NAMPT) in the hippocampus.
    Summary · context
    The animal model of POCD was established in C57BL/6 J mice through 6 h isoflurane anesthesia-induced cognitive impairment.
    Summary · context
    Mice were intraperitoneally injected with NMN for 7 days prior to anesthesia, after which oxidative stress and cognitive function were assessed.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In POCD mice, NMN prevented the decline in hippocampal SIRT1 expression.

    In plain wordsIn mice with anesthesia-induced cognitive impairment, NMN prevented a decline in brain SIRT1 expression.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseHippocampal SIRT1 expression
    Study

    mousen: not reported in source

    Isoflurane-induced POCD in C57BL/6 J mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 7 days before anesthesiaAs given in this study (mouse).

    Source sentences

    Summary
    And NMN supplementation could effectively prevent the decline of NAD+ and related proteins, and reduce oxidative stress and cognitive disorders after POCD.
    3 context sentences
    Summary · context
    Our results showed that cognitive impairment and increased oxidative stress were observed in POCD mice, as well as downregulation of NAD+ levels and related protein expressions of SIRT1 and nicotinamide phosphoribosyltransferase (NAMPT) in the hippocampus.
    Summary · context
    The animal model of POCD was established in C57BL/6 J mice through 6 h isoflurane anesthesia-induced cognitive impairment.
    Summary · context
    Mice were intraperitoneally injected with NMN for 7 days prior to anesthesia, after which oxidative stress and cognitive function were assessed.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In POCD mice, NMN prevented the decline in hippocampal NAMPT expression.

    In plain wordsIn mice with anesthesia-induced cognitive impairment, NMN prevented a decline in brain NAMPT expression.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseHippocampal NAMPT expression
    Study

    mousen: not reported in source

    Isoflurane-induced POCD in C57BL/6 J mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 7 days before anesthesiaAs given in this study (mouse).

    Source sentences

    Summary
    And NMN supplementation could effectively prevent the decline of NAD+ and related proteins, and reduce oxidative stress and cognitive disorders after POCD.
    3 context sentences
    Summary · context
    Our results showed that cognitive impairment and increased oxidative stress were observed in POCD mice, as well as downregulation of NAD+ levels and related protein expressions of SIRT1 and nicotinamide phosphoribosyltransferase (NAMPT) in the hippocampus.
    Summary · context
    The animal model of POCD was established in C57BL/6 J mice through 6 h isoflurane anesthesia-induced cognitive impairment.
    Summary · context
    Mice were intraperitoneally injected with NMN for 7 days prior to anesthesia, after which oxidative stress and cognitive function were assessed.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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