Skip to content

Study · Animal study (in vivo) · 2024

8 results

Humanin ameliorates TBI-related cognitive impairment by attenuating mitochondrial dysfunction and inflammation.

Thapak P, Ying Z, Palafox-Sanchez V, Zhang G, Yang X, Gomez-Pinilla F

Biochimica et biophysica acta. Molecular basis of disease4 Nov 2023Cited by 12 (Europe PMC)

PMID37926362 (opens in a new tab)DOI10.1016/j.bbadis.2023.166937 (opens in a new tab)PepBankPUB-37926362
Publisher pagePubMedAsk about this study
Jump to 8 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In a traumatic brain injury model, humanin counteracted the TBI-related reduction in mitochondrial bioenergetics, including oxygen consumption rate.

    In plain wordsIn a brain injury model, humanin countered the drop in mitochondrial energy production caused by the injury.

    Peptide
    Humanin
    Outcome
    IncreaseMitochondrial bioenergetics including oxygen consumption rate
    Study

    n: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here we show that the mitochondrial activator humanin (HN) counteracts a TBI-related reduction in mitochondrial bioenergetics, including oxygen consumption rate.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In a traumatic brain injury model, humanin normalized the TBI-related disruption of memory function.

    In plain wordsIn a brain injury model, humanin brought memory function back toward normal.

    Peptide
    Humanin
    Outcome
    IncreaseMemory function
    Study

    n: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN normalized the disruptive action of TBI on memory function
  3. 03AnimalAnimal study (in vivo)Mechanism

    In a traumatic brain injury model, humanin restored levels of the synaptic protein synapsin 1.

    In plain wordsIn a brain injury model, humanin restored levels of a protein that supports connections between nerve cells.

    Peptide
    Humanin
    Outcome
    IncreaseSynapsin 1 level
    Study

    n: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN normalized the disruptive action of TBI on memory function, and restored levels of synaptic proteins (synapsin 1 and p-CREB).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In a traumatic brain injury model, humanin restored levels of the synaptic protein p-CREB.

    In plain wordsIn a brain injury model, humanin restored levels of a protein linked to nerve cell connections.

    Peptide
    Humanin
    Outcome
    Increasep-CREB level
    Study

    n: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN normalized the disruptive action of TBI on memory function, and restored levels of synaptic proteins (synapsin 1 and p-CREB).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In a traumatic brain injury model, humanin counteracted TBI-related elevations of pro-inflammatory cytokines in plasma.

    In plain wordsIn a brain injury model, humanin countered the rise in inflammatory signals in the blood.

    Peptide
    Humanin
    Outcome
    DecreasePlasma pro-inflammatory cytokines
    Study

    n: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN also counteracted TBI-related elevations of pro-inflammatory cytokines in plasma (TNF-α, INF-y, IL 17, IL 5, MCP 5, GCSF, RANNETS, sTNFRI)
  6. 06AnimalAnimal study (in vivo)Mechanism

    In a traumatic brain injury model, humanin counteracted the TBI-related elevation of gp-130 in the hippocampus.

    In plain wordsIn a brain injury model, humanin countered the rise of an inflammation-related protein in the memory region of the brain.

    Peptide
    Humanin
    Outcome
    DecreaseHippocampal gp-130
    Study

    n: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN also counteracted TBI-related elevations of pro-inflammatory cytokines in plasma (TNF-α, INF-y, IL 17, IL 5, MCP 5, GCSF, RANNETS, sTNFRI) as well as in the hippocampus (gp-130 and p-STAT3).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In a traumatic brain injury model, humanin counteracted the TBI-related elevation of p-STAT3 in the hippocampus.

    In plain wordsIn a brain injury model, humanin countered the rise of an inflammation-related protein in the memory region of the brain.

    Peptide
    Humanin
    Outcome
    DecreaseHippocampal p-STAT3
    Study

    n: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN also counteracted TBI-related elevations of pro-inflammatory cytokines in plasma (TNF-α, INF-y, IL 17, IL 5, MCP 5, GCSF, RANNETS, sTNFRI) as well as in the hippocampus (gp-130 and p-STAT3).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In a traumatic brain injury model, humanin reduced astrocyte proliferation.

    In plain wordsIn a brain injury model, humanin reduced the growth of astrocytes, a type of support cell in the brain.

    Peptide
    Humanin
    Outcome
    DecreaseAstrocyte proliferation
    Study

    n: not reported in source

    Traumatic brain injury (TBI)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, HN reduced astrocyte proliferation in TBI.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.