SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME.

Atreya MR, Piraino G, Cvijanovich NZ, Fitzgerald JC, Weiss SL, Bigham MT, Jain PN, Schwarz AJ, Lutfi R, Nowak J, Thomas NJ, Baines T, Haileselassie B, Zingarelli B

Shock (Augusta, Ga.)31 Oct 2023Cited by 1 (Europe PMC)

PMID37917869PMCIDPMC10842252DOI10.1097/shk.0000000000002266PepBankPUB-37917869

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured7

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In children with septic shock, serum humanin was higher in those with thrombocytopenia-associated multiorgan failure (TAMOF) than in those without.
In plain wordsIn children with septic shock, natural humanin levels were higher in those with a type of multiple organ failure than in those without.
Peptide
Humanin
Outcome
IncreaseSerum humanin and TAMOF phenotype
Study
n = 140
Comparator
Children without TAMOF
Analysis
Primary
Outcome group
Endogenous peptide levels · Whole body
Source sentences
Summary
The concentration of sHN was higher on day 1 relative to day 3 and among those with TAMOF phenotype in comparison to those without.
3 context sentences(design, population, supporting numbers)
Summary · context
The primary outcome was thrombocytopenia-associated multiorgan failure (TAMOF).
Summary · context
We sought to test the association between serum HN (sHN) concentrations and multiple-organ dysfunction syndrome in a prospectively enrolled cohort of pediatric septic shock.
Summary · context
Human MT-RNR2 ELISA was used to determine sHN concentrations on days 1 and 3.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3791786902
02HumanEndogenous levelObservational studyOther
In children with septic shock, the association between serum humanin and TAMOF was not significant after adjusting for age and illness severity.
In plain wordsIn children with septic shock, the link between natural humanin levels and multiple organ failure was not significant after adjusting for age and illness severity.
Peptide
Humanin
Outcome
No significant changeSerum humanin and TAMOF after adjustment for age and illness severity
Study
n = 140
Analysis
Primary
Outcome group
Endogenous peptide levels · Whole body
Source sentences
Summary
However, the association between sHN and TAMOF phenotype was not significant after adjusting for age and illness severity in multivariate models.
2 context sentences(design, population, supporting numbers)
Summary · context
We sought to test the association between serum HN (sHN) concentrations and multiple-organ dysfunction syndrome in a prospectively enrolled cohort of pediatric septic shock.
Summary · context
Human MT-RNR2 ELISA was used to determine sHN concentrations on days 1 and 3.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3791786903
03HumanEndogenous levelObservational studyOther
In children with septic shock, serum humanin was associated with the presence of day 7 sepsis-associated acute kidney injury.
In plain wordsIn children with septic shock, natural humanin levels were linked to kidney injury on day 7.
Peptide
Humanin
Outcome
Direction not reportedSerum humanin and day 7 sepsis-associated acute kidney injury
Study
n = 140
Analysis
Secondary
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
In secondary analyses, sHN was associated with presence of day 7 sepsis-associated acute kidney injury ( P = 0.049).
2 context sentences(design, population, supporting numbers)
Summary · context
We sought to test the association between serum HN (sHN) concentrations and multiple-organ dysfunction syndrome in a prospectively enrolled cohort of pediatric septic shock.
Summary · context
Human MT-RNR2 ELISA was used to determine sHN concentrations on days 1 and 3.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3791786904
04HumanEndogenous levelObservational studyOther
In children with septic shock, serum humanin was higher on day 1 than on day 3.
In plain wordsIn children with septic shock, the body's own humanin was higher on day 1 than on day 3.
Peptide
Humanin
Outcome
DecreaseSerum humanin on day 1 versus day 3
Study
n = 140
Comparator
Day 1
Outcome group
Endogenous peptide levels · Whole body
Source sentences
Summary
The concentration of sHN was higher on day 1 relative to day 3
2 context sentences(design, population, supporting numbers)
Summary · context
We sought to test the association between serum HN (sHN) concentrations and multiple-organ dysfunction syndrome in a prospectively enrolled cohort of pediatric septic shock.
Summary · context
Human MT-RNR2 ELISA was used to determine sHN concentrations on days 1 and 3.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3791786901
05HumanEndogenous levelObservational studyOther
In children with septic shock, serum humanin was higher in those in the high PERSEVERE mortality risk strata.
In plain wordsIn children with septic shock, natural humanin levels were higher in those at high risk of death by a biomarker score.
Peptide
Humanin
Outcome
IncreaseSerum humanin across PERSEVERE mortality risk strata
Study
n = 140
Comparator
Lower risk strata
Outcome group
Mortality · Whole body
Source sentences
Summary
sHN was higher among those with high PERSEVERE-mortality risk strata
2 context sentences(design, population, supporting numbers)
Summary · context
We sought to test the association between serum HN (sHN) concentrations and multiple-organ dysfunction syndrome in a prospectively enrolled cohort of pediatric septic shock.
Summary · context
Human MT-RNR2 ELISA was used to determine sHN concentrations on days 1 and 3.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3791786905
06HumanEndogenous levelObservational studyOther
In children with septic shock, serum humanin correlated with platelet counts.
In plain wordsIn children with septic shock, natural humanin levels were linked to platelet counts.
Peptide
Humanin
Outcome
Direction not reportedSerum humanin correlation with platelet counts
Study
n = 140
Outcome group
Endogenous peptide levels · Whole body
Source sentences
Summary
sHN was higher among those with high PERSEVERE-mortality risk strata and correlated with platelet counts and several markers of endothelial activation.
2 context sentences(design, population, supporting numbers)
Summary · context
We sought to test the association between serum HN (sHN) concentrations and multiple-organ dysfunction syndrome in a prospectively enrolled cohort of pediatric septic shock.
Summary · context
Human MT-RNR2 ELISA was used to determine sHN concentrations on days 1 and 3.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3791786906
07HumanEndogenous levelObservational studyOther
In children with septic shock, serum humanin correlated with several markers of endothelial activation.
In plain wordsIn children with septic shock, natural humanin levels were linked to several markers of blood vessel lining activation.
Peptide
Humanin
Outcome
Direction not reportedSerum humanin correlation with endothelial activation markers
Study
n = 140
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
sHN was higher among those with high PERSEVERE-mortality risk strata and correlated with platelet counts and several markers of endothelial activation.
2 context sentences(design, population, supporting numbers)
Summary · context
We sought to test the association between serum HN (sHN) concentrations and multiple-organ dysfunction syndrome in a prospectively enrolled cohort of pediatric septic shock.
Summary · context
Human MT-RNR2 ELISA was used to determine sHN concentrations on days 1 and 3.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3791786907

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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