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Study · Not a test of the peptide alone · 2023

4 results

Peptide Power: Mechanistic Insights into the Effect of Mitochondria-Targeted Tetrapeptides on Membrane Electrostatics from Molecular Simulations.

Tamucci JD, Alder NN, May ER

Molecular pharmaceutics30 Oct 2023Cited by 2 (Europe PMC)

PMID37904323 (opens in a new tab)PMCIDPMC10841697 (opens in a new tab)DOI10.1021/acs.molpharmaceut.3c00480 (opens in a new tab)PepBankPUB-37904323
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Elamipretide (SS-31).

  1. 01Computer modelNot a test of Elamipretide (SS-31) aloneIn silicoMechanism

    In molecular dynamics simulations, four mitochondria-targeted peptides including SS‑31 reduced the dipole potential of lipid bilayers by disordering lipid head groups and water layers.

    In plain wordsIn computer simulations, four mitochondria-targeted peptides, SS‑31 among them, lowered the dipole potential of a lipid membrane model.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMembrane dipole potential
    Study

    n: not reported in source

    all-atom molecular dynamics, lipid bilayers
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The simulations reveal that the MTPs achieve a reduction in the dipole potential by acting to disorder both lipid head groups and water layers proximal to the bilayer surface.
    1 context sentence
    Summary · context
    In this study, we employed all-atom molecular dynamics simulations (MD) to investigate the interactions of four MTPs with lipid bilayers and calculate their effect on structural and electrostatic properties.

    In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).

  2. 02Computer modelNot a test of Elamipretide (SS-31) aloneIn silicoMechanism

    In molecular dynamics simulations, four mitochondria-targeted peptides including SS‑31 decreased lipid bilayer thickness.

    In plain wordsIn computer simulations, four mitochondria-targeted peptides, SS‑31 among them, made a lipid membrane model thinner.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseBilayer thickness
    Study

    n: not reported in source

    all-atom molecular dynamics, lipid bilayers
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    We also find that MTPs decrease the bilayer thickness
    1 context sentence
    Summary · context
    In this study, we employed all-atom molecular dynamics simulations (MD) to investigate the interactions of four MTPs with lipid bilayers and calculate their effect on structural and electrostatic properties.

    In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).

  3. 03Computer modelNot a test of Elamipretide (SS-31) aloneIn silicoMechanism

    In molecular dynamics simulations, four mitochondria-targeted peptides including SS‑31 increased the capacitance of lipid bilayers.

    In plain wordsIn computer simulations, four mitochondria-targeted peptides, SS‑31 among them, raised the capacitance of a lipid membrane model.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMembrane capacitance
    Study

    n: not reported in source

    all-atom molecular dynamics, lipid bilayers
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    increase the membrane's capacitance.
    1 context sentence
    Summary · context
    In this study, we employed all-atom molecular dynamics simulations (MD) to investigate the interactions of four MTPs with lipid bilayers and calculate their effect on structural and electrostatic properties.

    In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).

  4. 04Computer modelNot a test of Elamipretide (SS-31) aloneIn silicoMechanism

    In molecular dynamics simulations, four mitochondria-targeted peptides including SS‑31 displaced cations away from the bilayer surface and modulated the surface potential.

    In plain wordsIn computer simulations, four mitochondria-targeted peptides, SS‑31 among them, pushed positive ions away from a lipid membrane model surface.

    Peptide
    Elamipretide (SS-31)
    Outcome
    MixedCation displacement and surface potential
    Study

    n: not reported in source

    all-atom molecular dynamics, lipid bilayers
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The MTPs also displace cations away from the bilayer surface, modulating the surface potential
    1 context sentence
    Summary · context
    In this study, we employed all-atom molecular dynamics simulations (MD) to investigate the interactions of four MTPs with lipid bilayers and calculate their effect on structural and electrostatic properties.

    In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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