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Study · Animal study (in vivo) · mouse · 2023

6 results

Intraperitoneal administration of mouse kisspeptin-10 to mice during estrus stage induces pseudopregnancy.

Mashiko D, Tokoro M, Yao T, Yamagata K

Genes to cells : devoted to molecular & cellular mechanisms27 Oct 2023Cited by 3 (Europe PMC)

PMID37886801 (opens in a new tab)DOI10.1111/gtc.13077 (opens in a new tab)PepBankPUB-37886801
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with gapping and reddish pink vagina, blastocyst transfer after mKp-10 administration gave a pregnancy rate of 65.2% (15/23).

    In plain wordsIn mice, after a kisspeptin‑10 injection, 65.2% (15 of 23) became pregnant after embryo transfer.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicablePregnancy rate after blastocyst transfer (gapping, reddish pink vagina)
    Study

    mousen = 23

    ICR mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Measurements

    Pregnancy rate
    65.2%
    gapping and reddish pink vagina

    Source sentences

    Summary
    Blastocyst transfer after mKp-10 administration to mice with gapping and reddish pink vagina resulted in 65.2% (15/23) pregnancies, and 39.1% (34/87) of the transferred blastocysts showed full-term growth.
    1 context sentence
    Summary · context
    In this study, pregnant ICR were obtained mice without mating with vasectomized mice via administration of mouse Kisspeptin-10 (mKp-10) and transferring blastocysts to the uterus.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice given mKp10 at the estrus stage (confirmed by vaginal smear), blastocyst transfer gave a pregnancy rate of 95.2% (20/21).

    In plain wordsIn mice given kisspeptin‑10 at the estrus stage, 95.2% (20 of 21) became pregnant after embryo transfer.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicablePregnancy rate after blastocyst transfer (estrus stage by vaginal smear)
    Study

    mousen = 21

    ICR mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Measurements

    Pregnancy rate
    95.2%
    estrus stage

    Source sentences

    Summary
    Vaginal smears were observed for accurate estrus cycle determination, and subsequent administration of mKp10 to mice during the estrus stage and blastocyst transfer resulted in 95.2% (20/21) pregnancies and 50.7% (104/205) birth rates.
    1 context sentence
    Summary · context
    In this study, pregnant ICR were obtained mice without mating with vasectomized mice via administration of mouse Kisspeptin-10 (mKp-10) and transferring blastocysts to the uterus.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice given mKp-10, 100% (8/8) became pregnant after 2-cell embryo transfer.

    In plain wordsIn mice given kisspeptin‑10, all 8 became pregnant after transfer of 2-cell embryos.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicablePregnancy rate after 2-cell embryo transfer
    Study

    mousen = 8

    ICR mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Measurements

    Pregnancy rate
    100%
    2-cell transfer

    Source sentences

    Summary
    Regarding 2-cell transfer after administration of mKp-10, 100% (8/8) of the mice became pregnant, and 45.0% (36/80) of the embryos were born.
    1 context sentence
    Summary · context
    In this study, pregnant ICR were obtained mice without mating with vasectomized mice via administration of mouse Kisspeptin-10 (mKp-10) and transferring blastocysts to the uterus.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with gapping and reddish pink vagina, 39.1% (34/87) of the blastocysts transferred after mKp-10 administration showed full-term growth.

    In plain wordsIn mice, after a kisspeptin‑10 injection, 39.1% of the transferred embryos grew to full term.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableFull-term growth of transferred blastocysts (gapping, reddish pink vagina)
    Study

    mousen: not reported in source

    ICR mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Measurements

    Full-term growth of transferred blastocysts
    39.1%
    gapping and reddish pink vagina

    Source sentences

    Summary
    Blastocyst transfer after mKp-10 administration to mice with gapping and reddish pink vagina resulted in 65.2% (15/23) pregnancies, and 39.1% (34/87) of the transferred blastocysts showed full-term growth.
    1 context sentence
    Summary · context
    In this study, pregnant ICR were obtained mice without mating with vasectomized mice via administration of mouse Kisspeptin-10 (mKp-10) and transferring blastocysts to the uterus.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice given mKp10 at the estrus stage, 50.7% (104/205) of transferred blastocysts were born.

    In plain wordsIn mice given kisspeptin‑10 at the estrus stage, 50.7% of the transferred embryos were born.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableBirth rate of transferred blastocysts (estrus stage)
    Study

    mousen: not reported in source

    ICR mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Measurements

    Birth rate
    50.7%
    estrus stage

    Source sentences

    Summary
    Vaginal smears were observed for accurate estrus cycle determination, and subsequent administration of mKp10 to mice during the estrus stage and blastocyst transfer resulted in 95.2% (20/21) pregnancies and 50.7% (104/205) birth rates.
    1 context sentence
    Summary · context
    In this study, pregnant ICR were obtained mice without mating with vasectomized mice via administration of mouse Kisspeptin-10 (mKp-10) and transferring blastocysts to the uterus.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice given mKp-10, 45.0% (36/80) of transferred 2-cell embryos were born.

    In plain wordsIn mice given kisspeptin‑10, 45.0% of the transferred 2-cell embryos were born.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableBirth rate of transferred 2-cell embryos
    Study

    mousen: not reported in source

    ICR mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Measurements

    Birth rate
    45%
    2-cell transfer

    Source sentences

    Summary
    Regarding 2-cell transfer after administration of mKp-10, 100% (8/8) of the mice became pregnant, and 45.0% (36/80) of the embryos were born.
    1 context sentence
    Summary · context
    In this study, pregnant ICR were obtained mice without mating with vasectomized mice via administration of mouse Kisspeptin-10 (mKp-10) and transferring blastocysts to the uterus.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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