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Study · In vitro (cells) · plasmodium falciparum · 2023

4 results

Identification of Novel, Potent, and Selective Compounds against Malaria Using Glideosomal-Associated Protein 50 as a Drug Target.

Agrawal P, Kumari S, Mohmmed A, Malhotra P, Sharma U, Sahal D

ACS omega6 Oct 2023Cited by 9 (Europe PMC)

PMID37867646 (opens in a new tab)PMCIDPMC10586260 (opens in a new tab)DOI10.1021/acsomega.3c05323 (opens in a new tab)PepBankPUB-37867646
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In lab tests, brilacidin was among eight compounds with submicromolar antiparasitic efficacy against malaria parasites.

    In plain wordsIn lab tests, brilacidin was among eight compounds with submicromolar antiparasitic efficacy against malaria parasites.

    Peptide
    Brilacidin
    Outcome
    DecreaseAntiparasitic efficacy
    Study

    Plasmodium falciparumn: not reported in source

    Malaria parasites
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    along with submicromolar range antiparasitic efficacy and selectivity index > 100 fold for malaria parasite.
    1 context sentence
    Summary · context
    eight compounds (Hayatinine, Curine, MMV689758 (Bedaquiline), MMV1634402 (Brilacidin), and MMV688271, MMV782353, MMV642550, and USINB4-124-8) were identified, which showed promising binding affinity (KD 100 fold…
  2. 02LabIn vitro (cells)Activity measurement

    In lab tests, brilacidin was among eight compounds with a selectivity index above 100 fold for malaria parasites.

    In plain wordsIn lab tests, brilacidin was among eight compounds with a selectivity index above 100 fold for malaria parasites.

    Peptide
    Brilacidin
    Outcome
    Not applicableSelectivity index
    Study

    Plasmodium falciparumn: not reported in source

    Malaria parasites
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Measurements

    Selectivity index
    > 100 fold
    malaria parasite

    Source sentences

    Summary
    along with submicromolar range antiparasitic efficacy and selectivity index > 100 fold for malaria parasite.
    1 context sentence
    Summary · context
    eight compounds (Hayatinine, Curine, MMV689758 (Bedaquiline), MMV1634402 (Brilacidin), and MMV688271, MMV782353, MMV642550, and USINB4-124-8) were identified, which showed promising binding affinity (KD 100 fold…
  3. 03LabIn vitro (cells)Activity measurement

    In lab tests, brilacidin was among eight compounds effective against chloroquine-resistant PfINDO and artemisinin-resistant PfCam3.1R359T strains.

    In plain wordsIn lab tests, brilacidin was among eight compounds effective against chloroquine-resistant PfINDO and artemisinin-resistant PfCam3.1R359T strains.

    Peptide
    Brilacidin
    Outcome
    DecreaseActivity against resistant strains
    Study

    Plasmodium falciparumn: not reported in source

    Malaria parasites
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These eight compounds were effective against Chloroquine-resistant PfINDO and Artemisinin-resistant PfCam3.1R359T strains.
    1 context sentence
    Summary · context
    eight compounds (Hayatinine, Curine, MMV689758 (Bedaquiline), MMV1634402 (Brilacidin), and MMV688271, MMV782353, MMV642550, and USINB4-124-8) were identified, which showed promising binding affinity (KD 100 fold…
  4. 04LabIn vitro (cells)Mechanism

    In lab tests, eight compounds including brilacidin acted differently at different asexual blood stages.

    In plain wordsIn lab tests, eight compounds including brilacidin acted differently at different asexual blood stages.

    Peptide
    Brilacidin
    Outcome
    Direction not reportedDevelopmental stage effects
    Study

    Plasmodium falciparumn: not reported in source

    Malaria parasites
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Studies on the effect of these compounds at asexual blood stages showed that these eight compounds act differently at different developmental stages, indicating the binding of these compounds to other Plasmodium proteins, in addition to PfGAP50.
    1 context sentence
    Summary · context
    eight compounds (Hayatinine, Curine, MMV689758 (Bedaquiline), MMV1634402 (Brilacidin), and MMV688271, MMV782353, MMV642550, and USINB4-124-8) were identified, which showed promising binding affinity (KD 100 fold…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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