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Study · Animal study (in vivo) · rat · 2024

6 results

Nicotinamide Mononucleotide Improves Spermatogenic Disorders in Aluminum-Exposed Rats by Modulating the Glycolytic Pathway.

Nong W, Wei G, Wang J, Lei X, Wang J, Wei Y, Dong M, He L

Biological trace element research18 Oct 2023Cited by 8 (Europe PMC)

PMID37851298 (opens in a new tab)DOI10.1007/s12011-023-03904-9 (opens in a new tab)PepBankPUB-37851298
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aluminum-exposed rats, NMN improved testicular damage.

    In plain wordsIn rats exposed to aluminum, NMN reduced testicular damage.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseTesticular damage
    Study

    ratn: not reported in source

    Aluminum chloride-exposed rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, after NMN treatment, there was a noticeable improvement in testicular damage among the rats, marked by increased sperm quality, reduced apoptosis, enhanced cell proliferation, improved Sertoli cell function, and an activated glycolytic metabolism.
    1 context sentence
    Summary · context
    This study aimed to investigate the protective effect of nicotinamide mononucleotide (NMN) on testicular spermatogenesis in aluminum chloride (AlCl3)-exposed rats and to elucidate the potential underlying mechanism.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aluminum-exposed rats, NMN increased sperm quality.

    In plain wordsIn rats exposed to aluminum, NMN improved sperm quality.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSperm quality
    Study

    ratn: not reported in source

    Aluminum chloride-exposed rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, after NMN treatment, there was a noticeable improvement in testicular damage among the rats, marked by increased sperm quality, reduced apoptosis, enhanced cell proliferation, improved Sertoli cell function, and an activated glycolytic metabolism.
    1 context sentence
    Summary · context
    This study aimed to investigate the protective effect of nicotinamide mononucleotide (NMN) on testicular spermatogenesis in aluminum chloride (AlCl3)-exposed rats and to elucidate the potential underlying mechanism.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aluminum-exposed rats, NMN reduced apoptosis.

    In plain wordsIn rats exposed to aluminum, NMN reduced cell death.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseApoptosis
    Study

    ratn: not reported in source

    Aluminum chloride-exposed rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, after NMN treatment, there was a noticeable improvement in testicular damage among the rats, marked by increased sperm quality, reduced apoptosis, enhanced cell proliferation, improved Sertoli cell function, and an activated glycolytic metabolism.
    1 context sentence
    Summary · context
    This study aimed to investigate the protective effect of nicotinamide mononucleotide (NMN) on testicular spermatogenesis in aluminum chloride (AlCl3)-exposed rats and to elucidate the potential underlying mechanism.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In aluminum-exposed rats, NMN enhanced cell proliferation.

    In plain wordsIn rats exposed to aluminum, NMN increased cell multiplication.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseCell proliferation
    Study

    ratn: not reported in source

    Aluminum chloride-exposed rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, after NMN treatment, there was a noticeable improvement in testicular damage among the rats, marked by increased sperm quality, reduced apoptosis, enhanced cell proliferation, improved Sertoli cell function, and an activated glycolytic metabolism.
    1 context sentence
    Summary · context
    This study aimed to investigate the protective effect of nicotinamide mononucleotide (NMN) on testicular spermatogenesis in aluminum chloride (AlCl3)-exposed rats and to elucidate the potential underlying mechanism.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In aluminum-exposed rats, NMN improved Sertoli cell function.

    In plain wordsIn rats exposed to aluminum, NMN improved Sertoli cell function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSertoli cell function
    Study

    ratn: not reported in source

    Aluminum chloride-exposed rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, after NMN treatment, there was a noticeable improvement in testicular damage among the rats, marked by increased sperm quality, reduced apoptosis, enhanced cell proliferation, improved Sertoli cell function, and an activated glycolytic metabolism.
    1 context sentence
    Summary · context
    This study aimed to investigate the protective effect of nicotinamide mononucleotide (NMN) on testicular spermatogenesis in aluminum chloride (AlCl3)-exposed rats and to elucidate the potential underlying mechanism.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In aluminum-exposed rats, NMN activated glycolytic metabolism.

    In plain wordsIn rats exposed to aluminum, NMN increased glycolytic metabolism.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseGlycolytic metabolism
    Study

    ratn: not reported in source

    Aluminum chloride-exposed rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, after NMN treatment, there was a noticeable improvement in testicular damage among the rats, marked by increased sperm quality, reduced apoptosis, enhanced cell proliferation, improved Sertoli cell function, and an activated glycolytic metabolism.
    1 context sentence
    Summary · context
    This study aimed to investigate the protective effect of nicotinamide mononucleotide (NMN) on testicular spermatogenesis in aluminum chloride (AlCl3)-exposed rats and to elucidate the potential underlying mechanism.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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