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Study · In vitro (cells) · penaeus monodon · 2023

10 results

Thymosin beta-4 participate in antibacterial immunity and wound healing in black tiger shrimp, Penaeus monodon.

Lin C, Qiu L, Wang P, Zhang B, Yan L, Zhao C

Fish & shellfish immunology7 Sept 2023Cited by 6 (Europe PMC)

PMID37689229 (opens in a new tab)DOI10.1016/j.fsi.2023.109065 (opens in a new tab)PepBankPUB-37689229
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In lab tests, recombinant PmTβ4 inhibited the growth of gram-negative and gram-positive bacteria, including Vibrio vulnificus, V. parahaemolyticus, Streptococcus agalactiae, S. aureus and Aeromonas hydrophila.

    In plain wordsIn lab tests, the recombinant shrimp protein stopped growth of several gram-negative and gram-positive bacteria.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseAntimicrobial activity of recombinant PmTβ4
    Study

    Penaeus monodonn: not reported in source

    Bacterial cultures
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro antimicrobial test showed that the recombinant protein of PmTβ4 (rPmTβ4) had broad-spectrum of antimicrobial activity, which could inhibit both the growth of gram-negative bacteria and gram-positive bacteria, including Vibrio vulnificus, V. parahaemolyticus, Streptococcus agalactiae, S. aur…
    1 context sentence
    Summary · context
    In this study, the full-length cDNA of Tβ4 was cloned from Penaeus monodon (designated as PmTβ4), using the technology of rapid amplification of cDNA ends (RACE).
  2. 02LabIn vitro (cells)Activity measurement

    In lab tests, recombinant PmTβ4 bound to different bacteria, and the binding was strongly dose-dependent.

    In plain wordsIn lab tests, the recombinant shrimp protein bound to different bacteria, and more protein gave more binding.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableBacterial binding of recombinant PmTβ4
    Study

    Penaeus monodonn: not reported in source

    Bacterial cultures
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, rPmTβ4 had a certain binding ability to different bacteria, and this binding ability exhibits a strong dose-dependent effect.
    1 context sentence
    Summary · context
    In this study, the full-length cDNA of Tβ4 was cloned from Penaeus monodon (designated as PmTβ4), using the technology of rapid amplification of cDNA ends (RACE).

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In black tiger shrimp, PmTβ4 was expressed in all tested tissues, highest in hemolymph and lowest in muscle.

    In plain wordsIn shrimp, the shrimp's own Tβ4-like protein was found in all tested tissues, most in hemolymph and least in muscle.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicablePmTβ4 expression across tissues
    Study

    Penaeus monodonn: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The Quantitative Real-time PCR (qRT-PCR) analysis results showed that PmTβ4 was ubiquitously expressed in all the tested shrimp tissues, with the highest expression level was detected in the hemolymph, while the lowest expression level in the muscle.
    1 context sentence
    Summary · context
    In this study, the full-length cDNA of Tβ4 was cloned from Penaeus monodon (designated as PmTβ4), using the technology of rapid amplification of cDNA ends (RACE).

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In shrimp hepatopancreas, PmTβ4 expression was up-regulated after challenge with Vibrio parahaemolyticus, Vibrio harveyi and Staphylococcus aureus.

    In plain wordsIn shrimp, the shrimp's own Tβ4-like protein increased in the hepatopancreas after bacterial challenge.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePmTβ4 expression after bacterial challenge
    Study

    Penaeus monodonn: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The expression level of PmTβ4 was significantly up-regulated in hepatopancreas after challenged by Vibrio parahaemolyticus, Vibrio harveyi and Staphylococcus aureus.
    1 context sentence
    Summary · context
    In this study, the full-length cDNA of Tβ4 was cloned from Penaeus monodon (designated as PmTβ4), using the technology of rapid amplification of cDNA ends (RACE).

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 05AnimalEndogenous levelAnimal study (in vivo)Other

    In shrimp, PmTβ4 expression was significantly up-regulated by injury treatment.

    In plain wordsIn shrimp, the shrimp's own Tβ4-like protein increased after injury.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePmTβ4 expression after injury
    Study

    Penaeus monodonn: not reported in source

    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    The results showed that the PmTβ4 expression was significantly up-regulated by injury treatment, and exerted positive effects to promote wound healing.
    1 context sentence
    Summary · context
    In this study, the full-length cDNA of Tβ4 was cloned from Penaeus monodon (designated as PmTβ4), using the technology of rapid amplification of cDNA ends (RACE).

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone5

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 06AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In shrimp, PmTβ4 facilitated clearance of external bacteria.

    In plain wordsIn shrimp, the shrimp's own Tβ4-like protein helped clear bacteria from outside the body.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseExternal bacterial clearance
    Study

    Penaeus monodonn: not reported in source

    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    In vivo, PmTβ4 could facilitate external bacterial clearance in shrimp, and have beneficial to shrimp survival post V. parahaemolyticus infection.
    1 context sentence
    Summary · context
    In this study, the full-length cDNA of Tβ4 was cloned from Penaeus monodon (designated as PmTβ4), using the technology of rapid amplification of cDNA ends (RACE).

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 07AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In shrimp, PmTβ4 was beneficial to survival after V. parahaemolyticus infection.

    In plain wordsIn shrimp, the shrimp's own Tβ4-like protein was linked to better survival after infection.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSurvival after V. parahaemolyticus infection
    Study

    Penaeus monodonn: not reported in source

    Outcome group
    Mortality · Infection

    Source sentences

    Summary
    In vivo, PmTβ4 could facilitate external bacterial clearance in shrimp, and have beneficial to shrimp survival post V. parahaemolyticus infection.
    1 context sentence
    Summary · context
    In this study, the full-length cDNA of Tβ4 was cloned from Penaeus monodon (designated as PmTβ4), using the technology of rapid amplification of cDNA ends (RACE).

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 08AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In shrimp, PmTβ4 exerted positive effects to promote wound healing.

    In plain wordsIn shrimp, the shrimp's own Tβ4-like protein promoted wound healing.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseWound healing
    Study

    Penaeus monodonn: not reported in source

    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    The results showed that the PmTβ4 expression was significantly up-regulated by injury treatment, and exerted positive effects to promote wound healing.
    1 context sentence
    Summary · context
    In this study, the full-length cDNA of Tβ4 was cloned from Penaeus monodon (designated as PmTβ4), using the technology of rapid amplification of cDNA ends (RACE).

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 09AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In injured shrimp, PmTβ4 increased the expression level of superoxide dismutase.

    In plain wordsIn injured shrimp, the shrimp's own Tβ4-like protein raised expression of the antioxidant enzyme SOD.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSuperoxide dismutase (SOD) expression after injury
    Study

    Penaeus monodonn: not reported in source

    Outcome group
    Oxidative stress · Skin and wound

    Source sentences

    Summary
    PmTβ4 can significantly increase the expression level of superoxide dismutase (SOD) and Catalase (CAT) after injury treatment in shrimp
    1 context sentence
    Summary · context
    In this study, the full-length cDNA of Tβ4 was cloned from Penaeus monodon (designated as PmTβ4), using the technology of rapid amplification of cDNA ends (RACE).

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  5. 10AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In injured shrimp, PmTβ4 increased the expression level of catalase.

    In plain wordsIn injured shrimp, the shrimp's own Tβ4-like protein raised expression of the antioxidant enzyme CAT.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCatalase (CAT) expression after injury
    Study

    Penaeus monodonn: not reported in source

    Outcome group
    Oxidative stress · Skin and wound

    Source sentences

    Summary
    PmTβ4 can significantly increase the expression level of superoxide dismutase (SOD) and Catalase (CAT) after injury treatment in shrimp
    1 context sentence
    Summary · context
    In this study, the full-length cDNA of Tβ4 was cloned from Penaeus monodon (designated as PmTβ4), using the technology of rapid amplification of cDNA ends (RACE).

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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