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Study · In vitro (cells) · 2023

2 results

Effect of thymosin β4 on lipopolysaccharide‑stimulated brain microvascular endothelial cell remodeling: A possible role in blood‑brain barrier injury.

Stewart W, Hejl C, Guleria RS, Gupta S

Experimental and therapeutic medicine17 Aug 2023Cited by 1 (Europe PMC)

PMID37664684 (opens in a new tab)PMCIDPMC10469577 (opens in a new tab)DOI10.3892/etm.2023.12167 (opens in a new tab)PepBankPUB-37664684
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In LPS-stimulated human brain microvascular endothelial cells, pretreatment with Tβ4 reversed the LPS-induced damage of blood-brain barrier components.

    In plain wordsIn lab-grown human brain blood vessel cells, Tβ4 pretreatment reversed damage caused by LPS to blood-brain barrier components.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    MixedLPS-induced damage of BBB components (tight junction, inflammatory, apoptotic and adhesion genes)
    Study

    n: not reported in source

    Human brain microvascular endothelial cells (hBMVECs), LPS-stimulated
    Comparator
    LPS without Tβ4
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results suggested that pretreatment with Tβ4 reversed the LPS-induced damage of BBB components in hBMVECs.
    1 context sentence
    Summary · context
    In the present study, the protective effects of Tβ4 in lipopolysaccharide (LPS)-stimulated gene expression of several tight junction proteins, inflammatory genes, apoptotic genes, and adhesion genes in human brain microvascular endothelial cells (hBMVECs), one of the pivotal cell types in the BBB, were reported.
  2. 02LabIn vitro (cells)Mechanism

    In LPS-stimulated brain microvascular endothelial cells, the results identified neuregulin 1 as a possible target for Tβ4.

    In plain wordsIn cells, the results pointed to neuregulin 1 as a possible target of Tβ4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableNeuregulin 1 as a possible Tβ4 target
    Study

    n: not reported in source

    Human brain microvascular endothelial cells (hBMVECs), LPS-stimulated
    Comparator
    LPS without Tβ4
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, these results identified neuregulin 1 as a possible target for Tβ4.
    1 context sentence
    Summary · context
    In the present study, the protective effects of Tβ4 in lipopolysaccharide (LPS)-stimulated gene expression of several tight junction proteins, inflammatory genes, apoptotic genes, and adhesion genes in human brain microvascular endothelial cells (hBMVECs), one of the pivotal cell types in the BBB, were reported.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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