Skip to content

Study · Not a test of the peptide alone · 2023

1 result

Therapeutic Effect of Prolyl Endopeptidase Inhibitor in High-fat Diet-induced Metabolic Dysfunction-associated Fatty Liver Disease.

Zhang JB, Li MT, Lin SZ, Cheng YQ, Fan JG, Chen YW

Journal of clinical and translational hepatology19 Apr 2023Cited by 5 (Europe PMC)

PMID37577240 (opens in a new tab)PMCIDPMC10412699 (opens in a new tab)DOI10.14218/jcth.2022.00110 (opens in a new tab)PepBankPUB-37577240
Read at sourcePubMedAsk about this study
Jump to 1 result

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In high-fat diet mice, increased PREP mainly activated the MMP8/9-PREP-PGP axis rather than the thymosin β4-meprin α/PREP-AcSDKP axis.

    In plain wordsIn mice on a high-fat diet, a liver enzyme pathway not involving thymosin β4 was the main one switched on.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTβ4-meprin α/PREP-AcSDKP axis in HFD mice
    Study

    mousen: not reported in source

    High-fat diet-induced MAFLD model
    Outcome group
    Receptor activity and mechanism · Liver

    Source sentences

    Summary
    PREP activity and expression were increased in HFD-mice compared with control mice from the 12th week onwards, and increased PREP mainly resulted in the activation of the matrix metalloproteinase 8/9 (MMP8/9)-PREP-PGP axis rather than the thymosin β4-meprin α/PREP-AcSDKP axis.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.