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Study · Animal study (in vivo) · rat · 2023

7 results

Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect.

Kalogjera L, Krezic I, Smoday IM, Vranes H, Zizek H, Yago H, Oroz K, Vukovic V, Kavelj I, Novosel L, Zubcic S, Barisic I and 8 more

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Beketic Oreskovic L, Strbe S, Sever M, Sjekavica I, Skrtic A, Boban Blagaic A, Seiwerth S, Sikiric P

World journal of gastroenterology1 Jul 2023Cited by 12 (Europe PMC)

PMID37545637 (opens in a new tab)PMCIDPMC10401663 (opens in a new tab)DOI10.3748/wjg.v29.i27.4289 (opens in a new tab)PepBankPUB-37545637
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with stomach perforation, BPC‑157 applied into the perforated defect induced immediate shrinking and contraction of the whole stomach, whereas saline was followed by considerable stomach enlargement.

    In plain wordsIn rats with a stomach hole, BPC‑157 made the stomach shrink and contract, while the stomach enlarged with saline.

    Peptide
    BPC-157
    Outcome
    DecreaseStomach size after perforation
    Study

    Ratsn: not reported in source

    Stomach perforation in deeply anesthetized rats with complete calvariectomy and laparotomy (occlusion/occlusion-like syndrome)
    Comparator
    Saline (5 mL/kg, 1 mL/rat)
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 µg or 10 ng/kg · Into the perforated defect in the stomach · Applied at 5 min post-perforation; sacrifice at 15 min or 60 min post-perforationAs given in this study (Rats).

    Source sentences

    Summary
    BPC 157 therapy (into the perforated defect), induced immediate shrinking and contraction of the whole stomach (unlike considerable enlargement by saline application).
    2 context sentences
    Summary · context
    The procedure included deeply anesthetized rats, complete calvariectomy, laparotomy at 15 min thereafter, and stomach perforation to rapidly induce vascular and multiorgan failure occlusion/occlusion-like syndrome.
    Summary · context
    At 5 min post-perforation time, rats received therapy [BPC 157 (10 µg or 10 ng/kg) or saline (5 mL/kg, 1 mL/rat) (controls)] into the perforated defect in the stomach).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with stomach perforation, BPC‑157 attenuated or eliminated intracranial (superior sagittal sinus), portal and caval hypertension and aortal hypotension.

    In plain wordsIn rats with a stomach hole, BPC‑157 reduced or removed abnormal high vein pressures and low aorta pressure.

    Peptide
    BPC-157
    Outcome
    MixedIntracranial, portal and caval hypertension and aortal hypotension
    Study

    Ratsn: not reported in source

    Stomach perforation in deeply anesthetized rats with complete calvariectomy and laparotomy (occlusion/occlusion-like syndrome)
    Comparator
    Saline (5 mL/kg, 1 mL/rat)
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    10 µg or 10 ng/kg · Into the perforated defect in the stomach · Applied at 5 min post-perforation; sacrifice at 15 min or 60 min post-perforationAs given in this study (Rats).

    Source sentences

    Summary
    attenuated/eliminated the intracranial (superior sagittal sinus), portal and caval hypertension, and aortal hypotension.
    2 context sentences
    Summary · context
    The procedure included deeply anesthetized rats, complete calvariectomy, laparotomy at 15 min thereafter, and stomach perforation to rapidly induce vascular and multiorgan failure occlusion/occlusion-like syndrome.
    Summary · context
    At 5 min post-perforation time, rats received therapy [BPC 157 (10 µg or 10 ng/kg) or saline (5 mL/kg, 1 mL/rat) (controls)] into the perforated defect in the stomach).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with stomach perforation, BPC‑157 therapy induced direct blood delivery via the azygos vein.

    In plain wordsIn rats with a stomach hole, BPC‑157 led to blood flowing directly through the azygos vein.

    Peptide
    BPC-157
    Outcome
    IncreaseDirect blood delivery via the azygos vein
    Study

    Ratsn: not reported in source

    Stomach perforation in deeply anesthetized rats with complete calvariectomy and laparotomy (occlusion/occlusion-like syndrome)
    Comparator
    Saline (5 mL/kg, 1 mL/rat)
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    10 µg or 10 ng/kg · Into the perforated defect in the stomach · Applied at 5 min post-perforation; sacrifice at 15 min or 60 min post-perforationAs given in this study (Rats).

    Source sentences

    Summary
    Accordingly, BPC 157 therapy induced direct blood delivery via the azygos vein
    2 context sentences
    Summary · context
    The procedure included deeply anesthetized rats, complete calvariectomy, laparotomy at 15 min thereafter, and stomach perforation to rapidly induce vascular and multiorgan failure occlusion/occlusion-like syndrome.
    Summary · context
    At 5 min post-perforation time, rats received therapy [BPC 157 (10 µg or 10 ng/kg) or saline (5 mL/kg, 1 mL/rat) (controls)] into the perforated defect in the stomach).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with stomach perforation, BPC‑157 therapy markedly reduced or eliminated thrombosis in the inferior caval vein, portal vein, abdominal aorta and superior sagittal sinus.

    In plain wordsIn rats with a stomach hole, BPC‑157 greatly reduced or removed blood clots in veins, the aorta and a brain sinus.

    Peptide
    BPC-157
    Outcome
    DecreaseThrombosis in peripheral vessels and the superior sagittal sinus
    Study

    Ratsn: not reported in source

    Stomach perforation in deeply anesthetized rats with complete calvariectomy and laparotomy (occlusion/occlusion-like syndrome)
    Comparator
    Saline (5 mL/kg, 1 mL/rat)
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    10 µg or 10 ng/kg · Into the perforated defect in the stomach · Applied at 5 min post-perforation; sacrifice at 15 min or 60 min post-perforationAs given in this study (Rats).

    Source sentences

    Summary
    Thrombosis, peripherally (inferior caval vein, portal vein, abdominal aorta) and centrally (superior sagittal sinus) BPC 157 therapy markedly reduced/annihilated.
    2 context sentences
    Summary · context
    The procedure included deeply anesthetized rats, complete calvariectomy, laparotomy at 15 min thereafter, and stomach perforation to rapidly induce vascular and multiorgan failure occlusion/occlusion-like syndrome.
    Summary · context
    At 5 min post-perforation time, rats received therapy [BPC 157 (10 µg or 10 ng/kg) or saline (5 mL/kg, 1 mL/rat) (controls)] into the perforated defect in the stomach).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with stomach perforation, BPC‑157 therapy markedly reduced severe brain lesions (swelling, hemorrhage).

    In plain wordsIn rats with a stomach hole, BPC‑157 reduced brain swelling and bleeding.

    Peptide
    BPC-157
    Outcome
    DecreaseBrain swelling and hemorrhage
    Study

    Ratsn: not reported in source

    Stomach perforation in deeply anesthetized rats with complete calvariectomy and laparotomy (occlusion/occlusion-like syndrome)
    Comparator
    Saline (5 mL/kg, 1 mL/rat)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 µg or 10 ng/kg · Into the perforated defect in the stomach · Applied at 5 min post-perforation; sacrifice at 15 min or 60 min post-perforationAs given in this study (Rats).

    Source sentences

    Summary
    Severe lesions in the brain (swelling, hemorrhage), heart (congestion and arrhythmias), lung (hemorrhage and congestion), and marked congestion in the liver, kidney, and gastrointestinal tract were markedly reduced.
    2 context sentences
    Summary · context
    The procedure included deeply anesthetized rats, complete calvariectomy, laparotomy at 15 min thereafter, and stomach perforation to rapidly induce vascular and multiorgan failure occlusion/occlusion-like syndrome.
    Summary · context
    At 5 min post-perforation time, rats received therapy [BPC 157 (10 µg or 10 ng/kg) or saline (5 mL/kg, 1 mL/rat) (controls)] into the perforated defect in the stomach).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with stomach perforation, BPC‑157 therapy markedly reduced severe heart lesions (congestion and arrhythmias).

    In plain wordsIn rats with a stomach hole, BPC‑157 reduced heart congestion and irregular heartbeats.

    Peptide
    BPC-157
    Outcome
    DecreaseHeart congestion and arrhythmias
    Study

    Ratsn: not reported in source

    Stomach perforation in deeply anesthetized rats with complete calvariectomy and laparotomy (occlusion/occlusion-like syndrome)
    Comparator
    Saline (5 mL/kg, 1 mL/rat)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10 µg or 10 ng/kg · Into the perforated defect in the stomach · Applied at 5 min post-perforation; sacrifice at 15 min or 60 min post-perforationAs given in this study (Rats).

    Source sentences

    Summary
    Severe lesions in the brain (swelling, hemorrhage), heart (congestion and arrhythmias), lung (hemorrhage and congestion), and marked congestion in the liver, kidney, and gastrointestinal tract were markedly reduced.
    2 context sentences
    Summary · context
    The procedure included deeply anesthetized rats, complete calvariectomy, laparotomy at 15 min thereafter, and stomach perforation to rapidly induce vascular and multiorgan failure occlusion/occlusion-like syndrome.
    Summary · context
    At 5 min post-perforation time, rats received therapy [BPC 157 (10 µg or 10 ng/kg) or saline (5 mL/kg, 1 mL/rat) (controls)] into the perforated defect in the stomach).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with stomach perforation, BPC‑157 therapy markedly reduced lung lesions (hemorrhage, congestion) and marked congestion in the liver, kidney and gastrointestinal tract.

    In plain wordsIn rats with a stomach hole, BPC‑157 reduced bleeding and congestion in the lungs, and congestion in the liver, kidney and gut.

    Peptide
    BPC-157
    Outcome
    DecreaseLung hemorrhage and congestion; congestion in liver, kidney and gastrointestinal tract
    Study

    Ratsn: not reported in source

    Stomach perforation in deeply anesthetized rats with complete calvariectomy and laparotomy (occlusion/occlusion-like syndrome)
    Comparator
    Saline (5 mL/kg, 1 mL/rat)
    Outcome group
    Organ injury · Whole body
    Studied dose
    10 µg or 10 ng/kg · Into the perforated defect in the stomach · Applied at 5 min post-perforation; sacrifice at 15 min or 60 min post-perforationAs given in this study (Rats).

    Source sentences

    Summary
    Severe lesions in the brain (swelling, hemorrhage), heart (congestion and arrhythmias), lung (hemorrhage and congestion), and marked congestion in the liver, kidney, and gastrointestinal tract were markedly reduced.
    2 context sentences
    Summary · context
    The procedure included deeply anesthetized rats, complete calvariectomy, laparotomy at 15 min thereafter, and stomach perforation to rapidly induce vascular and multiorgan failure occlusion/occlusion-like syndrome.
    Summary · context
    At 5 min post-perforation time, rats received therapy [BPC 157 (10 µg or 10 ng/kg) or saline (5 mL/kg, 1 mL/rat) (controls)] into the perforated defect in the stomach).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 12:39 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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