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Study · Measured the body's own peptide · 2023

1 result

PFAS association with kisspeptin and sex hormones in teenagers of the HBM4EU aligned studies.

Rodríguez-Carrillo A, Remy S, Koppen G, Wauters N, Freire C, Olivas-Martínez A, Schillemans T, Åkesson A, Desalegn A, Iszatt N, den Hond E, Verheyen V and 12 more

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Fábelová L, Murinova LP, Pedraza-Díaz S, Castaño A, García-Lario JV, Cox B, Govarts E, Baken K, Tena-Sempere M, Olea N, Schoeters G, Fernández MF

Environmental pollution (Barking, Essex : 1987)21 Jul 2023Cited by 17 (Europe PMC)

PMID37482334 (opens in a new tab)DOI10.1016/j.envpol.2023.122214 (opens in a new tab)PepBankPUB-37482334
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In European teenage males, Bayesian kernel machine regression linked a PFAS mixture to a significant increase in serum kisspeptin‑54 levels.

    In plain wordsIn teenage boys, higher PFAS exposure was linked to higher levels of the body's own kisspeptin‑54.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseSerum kisspeptin-54 in males, PFAS mixture association
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The BKMR showed the same patterns observed in G-computation, including a significant increase on male Kiss-54 and SHBG levels.
    2 context sentences
    Summary · context
    For this purpose, PFAS compounds were measured in 733 teenagers from Belgium (FLEHS IV study), Slovakia (PCB cohort follow-up), and Spain (BEA study) by high performance liquid chromatography-tandem mass spectrometry (HPLC/MS) in laboratories under the HBM4EU quality assurance quality control (QA/QC) program.
    Summary · context
    In the same serum samples, kisspeptin 54 (kiss-54) protein, follicle-stimulating hormone (FSH), total testosterone (TT), estradiol (E2), and sex hormone-binding globulin (SHBG) levels were also measured using immunosorbent assays.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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