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Study · Animal study (in vivo) · mouse · 2023

4 results

Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: A focus on oxidative stress, inflammation, and apoptosis.

Bulut F, Adam M, Özgen A, Hekim MG, Ozcan S, Canpolat S, Ozcan M

Behavioural brain research17 Jul 2023Cited by 18 (Europe PMC)

PMID37467966 (opens in a new tab)DOI10.1016/j.bbr.2023.114584 (opens in a new tab)PepBankPUB-37467966
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with streptozotocin-induced diabetes, humanin treatment modulated blood glucose.

    In plain wordsIn diabetic mice, humanin treatment changed blood sugar compared with untreated diabetic mice.

    Peptide
    Humanin
    Outcome
    Direction not reportedBlood glucose
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes
    Comparator
    STZ diabetic control group
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    4 mg/kg · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    However, HN treatment was able to modulate these markers, including blood glucose and the markers of oxidative stress, inflammation, and apoptosis.
    2 context sentences
    Summary · context
    We divided the mice into four groups, including a control group (treated with saline), a humanin group (treated with 4 mg/kg of HN), a streptozotocin (STZ) group (diabetic control), and an STZ+Humanin group.
    Summary · context
    The mice were administered HN daily for 15 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with streptozotocin-induced diabetes, humanin treatment modulated markers of oxidative stress in the prefrontal cortex and hippocampus.

    In plain wordsIn diabetic mice, humanin treatment changed oxidative stress markers in the brain compared with untreated diabetic mice.

    Peptide
    Humanin
    Outcome
    Direction not reportedOxidative stress markers in prefrontal cortex and hippocampus
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes
    Comparator
    STZ diabetic control group
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    4 mg/kg · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    However, HN treatment was able to modulate these markers, including blood glucose and the markers of oxidative stress, inflammation, and apoptosis.
    3 context sentences
    Summary · context
    Our results showed that in the prefrontal cortex and hippocampus of the diabetes group, oxidative stress parameters, pro-inflammatory cytokines, apoptosis and, blood glucose levels were increased, while antioxidant and anti-inflammatory cytokines were diminished compared to the control group.
    Summary · context
    We divided the mice into four groups, including a control group (treated with saline), a humanin group (treated with 4 mg/kg of HN), a streptozotocin (STZ) group (diabetic control), and an STZ+Humanin group.
    Summary · context
    The mice were administered HN daily for 15 days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with streptozotocin-induced diabetes, humanin treatment modulated markers of inflammation in the prefrontal cortex and hippocampus.

    In plain wordsIn diabetic mice, humanin treatment changed inflammation markers in the brain compared with untreated diabetic mice.

    Peptide
    Humanin
    Outcome
    Direction not reportedInflammation markers in prefrontal cortex and hippocampus
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes
    Comparator
    STZ diabetic control group
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    4 mg/kg · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    However, HN treatment was able to modulate these markers, including blood glucose and the markers of oxidative stress, inflammation, and apoptosis.
    3 context sentences
    Summary · context
    Our results showed that in the prefrontal cortex and hippocampus of the diabetes group, oxidative stress parameters, pro-inflammatory cytokines, apoptosis and, blood glucose levels were increased, while antioxidant and anti-inflammatory cytokines were diminished compared to the control group.
    Summary · context
    We divided the mice into four groups, including a control group (treated with saline), a humanin group (treated with 4 mg/kg of HN), a streptozotocin (STZ) group (diabetic control), and an STZ+Humanin group.
    Summary · context
    The mice were administered HN daily for 15 days.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with streptozotocin-induced diabetes, humanin treatment modulated markers of apoptosis in the prefrontal cortex and hippocampus.

    In plain wordsIn diabetic mice, humanin treatment changed cell death markers in the brain compared with untreated diabetic mice.

    Peptide
    Humanin
    Outcome
    Direction not reportedApoptosis markers in prefrontal cortex and hippocampus
    Study

    mousen: not reported in source

    Streptozotocin-induced diabetes
    Comparator
    STZ diabetic control group
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    4 mg/kg · 15 daysAs given in this study (mouse).

    Source sentences

    Summary
    However, HN treatment was able to modulate these markers, including blood glucose and the markers of oxidative stress, inflammation, and apoptosis.
    3 context sentences
    Summary · context
    Our results showed that in the prefrontal cortex and hippocampus of the diabetes group, oxidative stress parameters, pro-inflammatory cytokines, apoptosis and, blood glucose levels were increased, while antioxidant and anti-inflammatory cytokines were diminished compared to the control group.
    Summary · context
    We divided the mice into four groups, including a control group (treated with saline), a humanin group (treated with 4 mg/kg of HN), a streptozotocin (STZ) group (diabetic control), and an STZ+Humanin group.
    Summary · context
    The mice were administered HN daily for 15 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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