Influence of semaglutide use on the presence of residual gastric solids on gastric ultrasound: a prospective observational study in volunteers without obesity recently started on semaglutide.

Sherwin M, Hamburger J, Katz D, DeMaria S Jr

Canadian journal of anaesthesia = Journal canadien d'anesthesie19 Jul 2023Cited by 86 (Europe PMC)

PMID37466909DOI10.1007/s12630-023-02549-5PepBankPUB-37466909

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanObservational studyOther
In adults without obesity, solids were present on gastric ultrasound in the supine position in 70% of semaglutide users versus 10% of controls after an eight-hour fast.
In plain wordsIn adults without obesity, food solids stayed in the stomach after fasting more often in people taking semaglutide than in controls.
Peptide
Semaglutide
Outcome
IncreaseSolid gastric contents on ultrasound, supine, after 8-hour fast
Study
n = 20
Comparator
Control participants
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
Dose not stated
Measurements
Participants with gastric solids
70%
semaglutide, supine
Participants with gastric solids
10%
controls, supine
Risk ratio
3.5
supine
Source sentences
Summary
In the supine position, 70% of semaglutide participants and 10% of control participants had solids present on gastric ultrasound (risk ratio [RR], 3.50; 95% confidence interval [CI], 1.26 to 9.65; P = 0.02.)
2 context sentences(design, population, supporting numbers)
Summary · context
In this prospective study, we used gastric ultrasound to evaluate the presence of solid gastric contents in both supine and lateral positions after an eight-hour fast in those taking GLP-1RA compared with controls.
Summary · context
Twenty adults voluntarily enrolled, giving a total of ten participants in each group.
Report a problemFND-3746690901
02HumanObservational studyOther
In adults without obesity, solids were present on gastric ultrasound in the lateral position in 90% of semaglutide users versus 20% of controls after an eight-hour fast.
In plain wordsIn adults without obesity, food solids stayed in the stomach after fasting more often in people taking semaglutide than in controls.
Peptide
Semaglutide
Outcome
IncreaseSolid gastric contents on ultrasound, lateral, after 8-hour fast
Study
n = 20
Comparator
Control participants
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
Dose not stated
Measurements
Participants with gastric solids
90%
semaglutide, lateral
Participants with gastric solids
20%
controls, lateral
Risk ratio
7.36
lateral
Source sentences
Summary
In the lateral position, 90% of semaglutide participants and 20% of control participants had solids identified on gastric ultrasound (RR, 7.36; 95% CI, 1.13 to 47.7; P = 0.005).
2 context sentences(design, population, supporting numbers)
Summary · context
In this prospective study, we used gastric ultrasound to evaluate the presence of solid gastric contents in both supine and lateral positions after an eight-hour fast in those taking GLP-1RA compared with controls.
Summary · context
Twenty adults voluntarily enrolled, giving a total of ten participants in each group.
Report a problemFND-3746690902
03HumanObservational studyOther
In adults without obesity, two hours after clear liquids the semaglutide and control groups did not differ in the lateral position.
In plain wordsIn adults without obesity, two hours after a drink, people on semaglutide and controls did not differ when lying on their side.
Peptide
Semaglutide
Outcome
No significant changeGastric emptiness 2 hours after clear liquids, lateral position
Study
n = 20
Comparator
Control participants
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
Two hours after drinking clear liquids, the two groups did not differ in the lateral position, but in the supine position, 90% of control group participants were rated as empty compared with only 30% of semaglutide group participants (P = 0.02).
2 context sentences(design, population, supporting numbers)
Summary · context
In this prospective study, we used gastric ultrasound to evaluate the presence of solid gastric contents in both supine and lateral positions after an eight-hour fast in those taking GLP-1RA compared with controls.
Summary · context
Twenty adults voluntarily enrolled, giving a total of ten participants in each group.
Report a problemFND-3746690903
04HumanObservational studyOther
In adults without obesity, two hours after clear liquids the stomach was rated empty in the supine position in 30% of semaglutide users versus 90% of controls.
In plain wordsIn adults without obesity, two hours after a drink, fewer people on semaglutide had an empty stomach when lying on their back than controls.
Peptide
Semaglutide
Outcome
DecreaseGastric emptiness 2 hours after clear liquids, supine position
Study
n = 20
Comparator
Control participants
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
Dose not stated
Measurements
Participants rated empty
30%
semaglutide, supine
Participants rated empty
90%
controls, supine
Source sentences
Summary
Two hours after drinking clear liquids, the two groups did not differ in the lateral position, but in the supine position, 90% of control group participants were rated as empty compared with only 30% of semaglutide group participants (P = 0.02).
2 context sentences(design, population, supporting numbers)
Summary · context
In this prospective study, we used gastric ultrasound to evaluate the presence of solid gastric contents in both supine and lateral positions after an eight-hour fast in those taking GLP-1RA compared with controls.
Summary · context
Twenty adults voluntarily enrolled, giving a total of ten participants in each group.
Report a problemFND-3746690904

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 1
9 Oct 2026, 03:06 UTC
First added · source update from Europe PMC

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