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Study · Animal study (in vivo) · mouse · 2023

3 results

SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop.

Shan Z, Wang Y, Qiu T, Zhou Y, Zhang Y, Hu L, Zhang L, Liang J, Ding M, Fan S, Xiao Z

The journal of headache and pain5 Jun 2023Cited by 17 (Europe PMC)

PMID37271805 (opens in a new tab)PMCIDPMC10240765 (opens in a new tab)DOI10.1186/s10194-023-01600-6 (opens in a new tab)PepBankPUB-37271805
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Summary

Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden. Improving mitochondrial function has promise as an effective treatment strategy for migraine. Szeto-Schiller peptide (SS-31) is a new mitochondria-targeted tetrapeptide molecule that has been shown to suppress the progression of diseases by restoring mitochondrial function, including renal disease, cardiac disease, and neurodegenerative disease. However, whether SS-31 has a therapeutic effect on migraine remains unclear. The aim of this study is to clarify the treatment of SS-31 for headache and its potential mechanisms. Here we used a mouse model induced by repeated dural infusion of inflammatory soup (IS), and examined roles of Sirt3/Pgc-1α positive feedback loop in headache pathogenesis and mitochondrial function. Our results showed that repeated IS infusion impaired mitochondrial function, mitochondrial ultrastructure and mitochondrial homeostasis in the trigeminal nucleus caudalis (TNC). These IS-induced damages in TNC were reversed by SS-31. In addition, IS-induced nociceptive responses were simultaneously alleviated. The effects of SS-31 on mitochondrial function and mitochondrial homeostasis (mainly mitochondrial biogenesis) were attenuated partially by the inhibitor of Sirt3/Pgc-1α. Overexpression of Sirt3/Pgc-1α increased the protein level of each other. These results indicated that SS-31 alleviated nociceptive responses and restored mitochondrial function in an IS-induced headache mouse model via Sirt3/Pgc-1α positive feedback loop. SS-31 has the potential to be an effective drug candidate for headache treatment.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with inflammatory soup-induced headache, SS‑31 reversed the damage to mitochondrial function, ultrastructure and homeostasis in the trigeminal nucleus caudalis.

    In plain wordsIn mice with induced headache, SS‑31 reversed damage to mitochondria in a pain-related brain region.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial function and structure in trigeminal nucleus caudalis
    Study

    mousen: not reported in source

    Mouse model of headache induced by repeated dural infusion of inflammatory soup (IS)
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These IS-induced damages in TNC were reversed by SS-31.
    1 context sentence
    Summary · context
    Here we used a mouse model induced by repeated dural infusion of inflammatory soup (IS), and examined roles of Sirt3/Pgc-1α positive feedback loop in headache pathogenesis and mitochondrial function.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with inflammatory soup-induced headache, SS‑31 alleviated nociceptive responses.

    In plain wordsIn mice with induced headache, SS‑31 reduced pain-related responses.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNociceptive responses
    Study

    mousen: not reported in source

    Mouse model of headache induced by repeated dural infusion of inflammatory soup (IS)
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, IS-induced nociceptive responses were simultaneously alleviated.
    1 context sentence
    Summary · context
    Here we used a mouse model induced by repeated dural infusion of inflammatory soup (IS), and examined roles of Sirt3/Pgc-1α positive feedback loop in headache pathogenesis and mitochondrial function.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with inflammatory soup-induced headache, an inhibitor of Sirt3/Pgc-1α partially attenuated the effects of SS‑31 on mitochondrial function and homeostasis.

    In plain wordsIn mice with induced headache, blocking Sirt3/Pgc-1α partly weakened the effects of SS‑31 on mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseSS-31 effect on mitochondrial function and biogenesis with Sirt3/Pgc-1α inhibitor
    Study

    mousen: not reported in source

    Mouse model of headache induced by repeated dural infusion of inflammatory soup (IS)
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effects of SS-31 on mitochondrial function and mitochondrial homeostasis (mainly mitochondrial biogenesis) were attenuated partially by the inhibitor of Sirt3/Pgc-1α.
    1 context sentence
    Summary · context
    Here we used a mouse model induced by repeated dural infusion of inflammatory soup (IS), and examined roles of Sirt3/Pgc-1α positive feedback loop in headache pathogenesis and mitochondrial function.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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