Nicotinamide mononucleotide improves the Alzheimer's disease by regulating intestinal microbiota.

Zhao X, Kong M, Wang Y, Mao Y, Xu H, He W, He Y, Gu J

Biochemical and biophysical research communications29 May 2023Cited by 22 (Europe PMC)

PMID37271037DOI10.1016/j.bbrc.2023.05.075PepBankPUB-37271037

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In APP/PS1 mice, NMN significantly changed intestinal microbial community composition.
In plain wordsIn mice with an Alzheimer disease model, NMN changed intestinal microbial composition.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
MixedMicrobial community composition
Study
mousen: not reported in source
APP/PS1 transgenic mice
Outcome group
Gut microbiota · Gastrointestinal
Studied dose
Dose not stated · 16 weeksAs given in this study (mouse).
Source sentences
Summary
The results show that the NMN significantly changed the intestinal microbial community composition in AD mice.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we investigated the relationship between gut flora and NMN treatment in APP/PS1 transgenic (AD) mice through the 16S ribosomal RNA (rRNA) high-throughput sequencing analysis of mouse feces after being treated with NMN for 16 weeks.
Report a problemFND-3727103701
02AnimalAnimal study (in vivo)Mechanism
In APP/PS1 mice, NMN increased relative Lactobacillus abundance.
In plain wordsIn mice with an Alzheimer disease model, NMN increased relative Lactobacillus abundance.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseLactobacillus abundance
Study
mousen: not reported in source
APP/PS1 transgenic mice
Outcome group
Gut microbiota · Gastrointestinal
Studied dose
Dose not stated · 16 weeksAs given in this study (mouse).
Source sentences
Summary
The NMN also increased the relative abundance of short-chain fatty acids (SCFAs)-producing bacteria such as Lactobacillus and Bacteroides at the genus level by protecting intestinal health and improving AD.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we investigated the relationship between gut flora and NMN treatment in APP/PS1 transgenic (AD) mice through the 16S ribosomal RNA (rRNA) high-throughput sequencing analysis of mouse feces after being treated with NMN for 16 weeks.
Report a problemFND-3727103702
03AnimalAnimal study (in vivo)Mechanism
In APP/PS1 mice, NMN increased relative Bacteroides abundance.
In plain wordsIn mice with an Alzheimer disease model, NMN increased relative Bacteroides abundance.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseBacteroides abundance
Study
mousen: not reported in source
APP/PS1 transgenic mice
Outcome group
Gut microbiota · Gastrointestinal
Studied dose
Dose not stated · 16 weeksAs given in this study (mouse).
Source sentences
Summary
The NMN also increased the relative abundance of short-chain fatty acids (SCFAs)-producing bacteria such as Lactobacillus and Bacteroides at the genus level by protecting intestinal health and improving AD.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we investigated the relationship between gut flora and NMN treatment in APP/PS1 transgenic (AD) mice through the 16S ribosomal RNA (rRNA) high-throughput sequencing analysis of mouse feces after being treated with NMN for 16 weeks.
Report a problemFND-3727103703

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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