Bioinspired Platelet-Anchored Electrospun Meshes for Tight Inflammation Manipulation and Chronic Diabetic Wound Healing.

Zhang T, Xiang Z, Liu L, Ma Z, Panteleev M, Ataullakhanov FI, Shi Q

Macromolecular bioscience13 Jun 2023Cited by 4 (Europe PMC)

PMID37259884DOI10.1002/mabi.202300036PepBankPUB-37259884

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

01AnimalNot a test of Thymosin beta-4 (human) aloneOther designEfficacy outcome
A platelet-anchored electrospun mesh loaded with Tβ4 and CaCl2 enhanced the initial macrophage recruitment in a diabetic wound setting.
In plain wordsA mesh holding thymosin β4, calcium chloride and platelets drew more immune cells early on in a diabetic wound setting.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseInitial macrophage recruitment
Study
n: not reported in source
Outcome group
Immune response · Skin and wound
Source sentences
Summary
It is demonstrated that the anchored platelets on electrospun mesh can enhance the initial macrophage recruitment and control the Tβ4 release from electrospun meshes to facilitate the macrophages polarization to the M2 phenotype.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3725988401
02AnimalNot a test of Thymosin beta-4 (human) aloneOther designEfficacy outcome
A platelet-anchored electrospun mesh loaded with Tβ4 and CaCl2 facilitated macrophage polarization to the M2 phenotype in a diabetic wound setting.
In plain wordsA mesh holding thymosin β4, calcium chloride and platelets pushed immune cells toward the healing M2 type in a diabetic wound setting.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseMacrophage polarization to the M2 phenotype
Study
n: not reported in source
Outcome group
Immune response · Skin and wound
Source sentences
Summary
It is demonstrated that the anchored platelets on electrospun mesh can enhance the initial macrophage recruitment and control the Tβ4 release from electrospun meshes to facilitate the macrophages polarization to the M2 phenotype.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3725988402
03AnimalNot a test of Thymosin beta-4 (human) aloneOther designMechanism
A platelet-anchored electrospun mesh loaded with Tβ4 and CaCl2 promoted expression of vascular endothelial growth factor.
In plain wordsA mesh holding thymosin β4, calcium chloride and platelets raised a blood-vessel growth factor.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseVascular endothelial growth factor expression
Study
n: not reported in source
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
The inflammatory regulation promotes the expression of vascular endothelial growth factor and the migration of vascular endothelial cells for angiogenesis, resulting in accelerated diabetic wounds healing.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3725988403
04AnimalNot a test of Thymosin beta-4 (human) aloneOther designEfficacy outcome
A platelet-anchored electrospun mesh loaded with Tβ4 and CaCl2 accelerated diabetic wound healing.
In plain wordsIn a diabetic wound model, a mesh holding thymosin β4, calcium chloride and platelets sped up wound healing.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseDiabetic wound healing
Study
n: not reported in source
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
The inflammatory regulation promotes the expression of vascular endothelial growth factor and the migration of vascular endothelial cells for angiogenesis, resulting in accelerated diabetic wounds healing.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3725988405
05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome
A platelet-anchored electrospun mesh loaded with Tβ4 and CaCl2 promoted the migration of vascular endothelial cells.
In plain wordsIn lab tests, a mesh holding thymosin β4, calcium chloride and platelets helped blood-vessel cells move.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseVascular endothelial cell migration
Study
n: not reported in source
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
The inflammatory regulation promotes the expression of vascular endothelial growth factor and the migration of vascular endothelial cells for angiogenesis, resulting in accelerated diabetic wounds healing.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3725988404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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