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Study · Animal study (in vivo) · mouse · 2023

6 results

NAD+ administration profoundly decreases UVC-induced skin damage by attenuating oxidative stress, inflammation, DNA damage and apoptosis.

Li M, Zhang M, Zhang Y, Liang Y, Ying W

International journal of physiology, pathophysiology and pharmacology15 Apr 2023Cited by 1 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NAD administration decreased UVC-induced skin damage.

    In plain wordsIn mice, NAD administration reduced UVC-induced skin damage.

    Outcome
    DecreaseSkin damage
    Study

    mousen: not reported in source

    UVC-induced skin damage mice
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    second, NAD+ administration profoundly decreased UVC-induced skin damage;
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, NAD administration attenuated UVC-induced decreases in mitochondrial superoxide dismutase levels.

    In plain wordsIn mice, NAD reduced the UVC-induced loss of mitochondrial superoxide dismutase.

    Outcome
    IncreaseMitochondrial superoxide dismutase levels
    Study

    mousen: not reported in source

    UVC-induced skin damage mice
    Outcome group
    Mitochondrial function · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    third, NAD+ administration significantly attenuated UVC-induced decreases in the levels of mitochondrial superoxide dismutase and catalase;
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, NAD administration attenuated UVC-induced decreases in catalase levels.

    In plain wordsIn mice, NAD reduced the UVC-induced loss of catalase.

    Outcome
    IncreaseCatalase levels
    Study

    mousen: not reported in source

    UVC-induced skin damage mice
    Outcome group
    Mitochondrial function · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    third, NAD+ administration significantly attenuated UVC-induced decreases in the levels of mitochondrial superoxide dismutase and catalase;
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, NAD administration attenuated the UVC-induced increase in COX 2 levels.

    In plain wordsIn mice, NAD reduced the UVC-induced increase in the inflammation marker COX 2.

    Outcome
    DecreaseCOX 2 levels
    Study

    mousen: not reported in source

    UVC-induced skin damage mice
    Outcome group
    Inflammation markers · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    fourth, NAD+ administration significantly attenuated UVC-induced increase in the level of cyclooxygenase (COX) 2 - a marker of inflammation;
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, NAD administration attenuated UVC-induced double-strand DNA damage.

    In plain wordsIn mice, NAD reduced UVC-induced double-strand DNA damage.

    Outcome
    DecreaseDouble-strand DNA damage
    Study

    mousen: not reported in source

    UVC-induced skin damage mice
    Outcome group
    Genome stability · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    fifth, NAD+ administration profoundly attenuated UVC-induced increase in double-strand DNA (dsDNA) damage;
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice, NAD administration attenuated UVC-induced decreases in the Bcl-2/Bax ratio, an apoptosis index.

    In plain wordsIn mice, NAD reduced the UVC-induced decrease in the Bcl-2/Bax ratio, an apoptosis marker.

    Outcome
    IncreaseBcl-2/Bax ratio
    Study

    mousen: not reported in source

    UVC-induced skin damage mice
    Outcome group
    Cell viability and death · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and sixth, NAD+ administration profoundly attenuated UVC-induced decreases in the ratios of Bcl-2/Bax - an index of apoptosis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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