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Study · Animal study (in vivo) · rat · 2023

14 results

Nicotinamide mononucleotide supplementation mitigates osteopenia induced by modeled microgravity in rats.

Huang Y, Dou Y, Yang B, He B, Zhang X, Zhang K, Yang X

Cell stress & chaperones17 May 2023Cited by 3 (Europe PMC)

PMID37195399 (opens in a new tab)PMCIDPMC10352228 (opens in a new tab)DOI10.1007/s12192-023-01356-7 (opens in a new tab)PepBankPUB-37195399
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hindlimb-unloaded rats, NMN increased bone mass.

    In plain wordsIn rats exposed to hindlimb unloading, NMN increased bone mass.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseBone mass
    Study

    ratn: not reported in source

    hindlimb unloading
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    500 mg/kg every 3 days · intragastric · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    NMN supplementation mitigated HLU-induced bone loss, evidenced by greater bone mass and biomechanical properties and better trabecular bone structure.
    1 context sentence
    Summary · context
    The 3-mo-old rats were exposed to HLU and intragastrically administered NMN every 3 days (500 mg/kg body weight) for 4 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hindlimb-unloaded rats, NMN improved bone biomechanical properties.

    In plain wordsIn rats exposed to hindlimb unloading, NMN improved bone mechanical properties.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseBone biomechanical properties
    Study

    ratn: not reported in source

    hindlimb unloading
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    500 mg/kg every 3 days · intragastric · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    NMN supplementation mitigated HLU-induced bone loss, evidenced by greater bone mass and biomechanical properties and better trabecular bone structure.
    1 context sentence
    Summary · context
    The 3-mo-old rats were exposed to HLU and intragastrically administered NMN every 3 days (500 mg/kg body weight) for 4 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In hindlimb-unloaded rats, NMN improved trabecular bone structure.

    In plain wordsIn rats exposed to hindlimb unloading, NMN improved bone structure.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseTrabecular structure
    Study

    ratn: not reported in source

    hindlimb unloading
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    500 mg/kg every 3 days · intragastric · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    NMN supplementation mitigated HLU-induced bone loss, evidenced by greater bone mass and biomechanical properties and better trabecular bone structure.
    1 context sentence
    Summary · context
    The 3-mo-old rats were exposed to HLU and intragastrically administered NMN every 3 days (500 mg/kg body weight) for 4 weeks.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In hindlimb-unloaded rats, NMN increased nicotinamide adenine dinucleotide levels.

    In plain wordsIn rats exposed to hindlimb unloading, NMN increased NAD levels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNAD levels
    Study

    ratn: not reported in source

    hindlimb unloading
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    500 mg/kg every 3 days · intragastric · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    NMN supplementation mitigated HLU-induced oxidative stress, evidenced by greater levels of nicotinamide adenine dinucleotide and activities of superoxide dismutase 2 and lesser malondialdehyde levels.
    1 context sentence
    Summary · context
    The 3-mo-old rats were exposed to HLU and intragastrically administered NMN every 3 days (500 mg/kg body weight) for 4 weeks.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In hindlimb-unloaded rats, NMN increased superoxide dismutase 2 activity.

    In plain wordsIn rats exposed to hindlimb unloading, NMN increased antioxidant enzyme activity.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSOD2 activity
    Study

    ratn: not reported in source

    hindlimb unloading
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    500 mg/kg every 3 days · intragastric · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    NMN supplementation mitigated HLU-induced oxidative stress, evidenced by greater levels of nicotinamide adenine dinucleotide and activities of superoxide dismutase 2 and lesser malondialdehyde levels.
    1 context sentence
    Summary · context
    The 3-mo-old rats were exposed to HLU and intragastrically administered NMN every 3 days (500 mg/kg body weight) for 4 weeks.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In hindlimb-unloaded rats, NMN reduced malondialdehyde levels.

    In plain wordsIn rats exposed to hindlimb unloading, NMN reduced malondialdehyde levels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMalondialdehyde
    Study

    ratn: not reported in source

    hindlimb unloading
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    500 mg/kg every 3 days · intragastric · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    NMN supplementation mitigated HLU-induced oxidative stress, evidenced by greater levels of nicotinamide adenine dinucleotide and activities of superoxide dismutase 2 and lesser malondialdehyde levels.
    1 context sentence
    Summary · context
    The 3-mo-old rats were exposed to HLU and intragastrically administered NMN every 3 days (500 mg/kg body weight) for 4 weeks.
  7. 07LabIn vitro (cells)Efficacy outcome

    In MC3T3-E1 cells, NMN reversed microgravity-induced inhibition of osteoblast differentiation.

    In plain wordsIn cells under modeled microgravity, NMN restored bone cell differentiation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseOsteoblast differentiation
    Study

    n: not reported in source

    MC3T3-E1 cells under modeled microgravity
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Modeled microgravity stimulation using rotary wall vessel bioreactor in MC3T3-E1 cells inhibited osteoblast differentiation, which was reversed by NMN treatment.
  8. 08LabIn vitro (cells)Efficacy outcome

    In cells under modeled microgravity, NMN reduced reactive oxygen species generation.

    In plain wordsIn cells under modeled microgravity, NMN reduced reactive oxygen species generation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseReactive oxygen species
    Study

    n: not reported in source

    MC3T3-E1 cells under modeled microgravity
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN treatment mitigated microgravity-induced mitochondrial impairments, evidenced by lesser reactive oxygen species generation and greater adenosine triphosphate production, mtDNA copy number, and activities of superoxide dismutase 2 and Complex I and II.
    1 context sentence
    Summary · context
    Modeled microgravity stimulation using rotary wall vessel bioreactor in MC3T3-E1 cells inhibited osteoblast differentiation, which was reversed by NMN treatment.
  9. 09LabIn vitro (cells)Efficacy outcome

    In cells under modeled microgravity, NMN increased ATP production.

    In plain wordsIn cells under modeled microgravity, NMN increased ATP production.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseATP production
    Study

    n: not reported in source

    MC3T3-E1 cells under modeled microgravity
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN treatment mitigated microgravity-induced mitochondrial impairments, evidenced by lesser reactive oxygen species generation and greater adenosine triphosphate production, mtDNA copy number, and activities of superoxide dismutase 2 and Complex I and II.
    1 context sentence
    Summary · context
    Modeled microgravity stimulation using rotary wall vessel bioreactor in MC3T3-E1 cells inhibited osteoblast differentiation, which was reversed by NMN treatment.
  10. 10LabIn vitro (cells)Efficacy outcome

    In cells under modeled microgravity, NMN increased mtDNA copy number.

    In plain wordsIn cells under modeled microgravity, NMN increased mitochondrial DNA copies.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasemtDNA copy number
    Study

    n: not reported in source

    MC3T3-E1 cells under modeled microgravity
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN treatment mitigated microgravity-induced mitochondrial impairments, evidenced by lesser reactive oxygen species generation and greater adenosine triphosphate production, mtDNA copy number, and activities of superoxide dismutase 2 and Complex I and II.
    1 context sentence
    Summary · context
    Modeled microgravity stimulation using rotary wall vessel bioreactor in MC3T3-E1 cells inhibited osteoblast differentiation, which was reversed by NMN treatment.
  11. 11LabIn vitro (cells)Efficacy outcome

    In cells under modeled microgravity, NMN increased superoxide dismutase 2 activity.

    In plain wordsIn cells under modeled microgravity, NMN increased antioxidant enzyme activity.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSOD2 activity
    Study

    n: not reported in source

    MC3T3-E1 cells under modeled microgravity
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN treatment mitigated microgravity-induced mitochondrial impairments, evidenced by lesser reactive oxygen species generation and greater adenosine triphosphate production, mtDNA copy number, and activities of superoxide dismutase 2 and Complex I and II.
    1 context sentence
    Summary · context
    Modeled microgravity stimulation using rotary wall vessel bioreactor in MC3T3-E1 cells inhibited osteoblast differentiation, which was reversed by NMN treatment.
  12. 12LabIn vitro (cells)Efficacy outcome

    In cells under modeled microgravity, NMN increased Complex I activity.

    In plain wordsIn cells under modeled microgravity, NMN increased Complex I activity.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseComplex I activity
    Study

    n: not reported in source

    MC3T3-E1 cells under modeled microgravity
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN treatment mitigated microgravity-induced mitochondrial impairments, evidenced by lesser reactive oxygen species generation and greater adenosine triphosphate production, mtDNA copy number, and activities of superoxide dismutase 2 and Complex I and II.
    1 context sentence
    Summary · context
    Modeled microgravity stimulation using rotary wall vessel bioreactor in MC3T3-E1 cells inhibited osteoblast differentiation, which was reversed by NMN treatment.
  13. 13LabIn vitro (cells)Efficacy outcome

    In cells under modeled microgravity, NMN increased Complex II activity.

    In plain wordsIn cells under modeled microgravity, NMN increased Complex II activity.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseComplex II activity
    Study

    n: not reported in source

    MC3T3-E1 cells under modeled microgravity
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN treatment mitigated microgravity-induced mitochondrial impairments, evidenced by lesser reactive oxygen species generation and greater adenosine triphosphate production, mtDNA copy number, and activities of superoxide dismutase 2 and Complex I and II.
    1 context sentence
    Summary · context
    Modeled microgravity stimulation using rotary wall vessel bioreactor in MC3T3-E1 cells inhibited osteoblast differentiation, which was reversed by NMN treatment.
  14. 14LabIn vitro (cells)Mechanism

    In the osteoblast experiments, NMN increased AMPKα phosphorylation.

    In plain wordsIn cells, NMN increased AMPKα phosphorylation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAMPK phosphorylation
    Study

    n: not reported in source

    MC3T3-E1 cells under modeled microgravity
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, NMN promoted activation of AMP-activated protein kinase (AMPK), evidenced by greater AMPKα phosphorylation.
    1 context sentence
    Summary · context
    Modeled microgravity stimulation using rotary wall vessel bioreactor in MC3T3-E1 cells inhibited osteoblast differentiation, which was reversed by NMN treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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