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Study · Animal study (in vivo) · mouse · 2023

5 results

Kisspeptin regulates airway hyperresponsiveness and remodeling in a mouse model of asthma.

Borkar NA, Ambhore NS, Balraj P, Ramakrishnan YS, Sathish V

The Journal of pathology12 May 2023Cited by 7 (Europe PMC)

PMID37171283 (opens in a new tab)PMCIDPMC10759912 (opens in a new tab)DOI10.1002/path.6086 (opens in a new tab)PepBankPUB-37171283
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with mixed allergen-induced asthma, chronic Kp-10 treatment significantly improved the altered lung functions.

    In plain wordsIn mice with allergic asthma, kisspeptin‑10 improved lung function that the allergen had worsened.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLung function in MA-challenged mice
    Study

    mousen: not reported in source

    C57BL/6J mice with mixed allergen (MA)-induced asthma
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    Dose not stated · intranasal · chronicAs given in this study (mouse).

    Source sentences

    Summary
    MA-challenged mice showed significant deterioration of lung function compared to those exposed to vehicle (DPBS); Kp-10 treatment significantly improved the MA-altered lung functions.
    1 context sentence
    Summary · context
    Utilizing C57BL/6J mice, we assessed the effect of chronic intranasal Kp-10 exposure on mixed allergen (MA)-induced mouse model of asthma.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice without allergen challenge, Kp-10 alone caused no notable changes in lung functions.

    In plain wordsIn mice without asthma, kisspeptin‑10 alone did not noticeably change lung function.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLung function in mice given Kp-10 alone
    Study

    mousen: not reported in source

    C57BL/6J mice without allergen challenge
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    Dose not stated · intranasal · chronicAs given in this study (mouse).

    Source sentences

    Summary
    Mice treated with Kp-10 alone did not show any notable changes in lung functions.
    1 context sentence
    Summary · context
    Utilizing C57BL/6J mice, we assessed the effect of chronic intranasal Kp-10 exposure on mixed allergen (MA)-induced mouse model of asthma.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with mixed allergen-induced asthma, Kp-10 treatment abrogated the increase in proinflammatory cytokines.

    In plain wordsIn mice with allergic asthma, kisspeptin‑10 blocked the rise in inflammation signals caused by the allergen.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseProinflammatory cytokines
    Study

    mousen: not reported in source

    C57BL/6J mice with mixed allergen (MA)-induced asthma
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intranasal · chronicAs given in this study (mouse).

    Source sentences

    Summary
    Proinflammatory cytokines were significantly increased upon MA exposure, an effect abrogated by Kp-10 treatment.
    1 context sentence
    Summary · context
    Utilizing C57BL/6J mice, we assessed the effect of chronic intranasal Kp-10 exposure on mixed allergen (MA)-induced mouse model of asthma.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with mixed allergen-induced asthma, Kp-10 exposure significantly reduced MA-induced smooth muscle mass in the lung.

    In plain wordsIn mice with allergic asthma, kisspeptin‑10 reduced the extra lung muscle caused by the allergen.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseSmooth muscle mass in the lung
    Study

    mousen: not reported in source

    C57BL/6J mice with mixed allergen (MA)-induced asthma
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated · intranasal · chronicAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, biochemical and histological studies showed Kp-10 exposure significantly reduced MA-induced smooth muscle mass and soluble collagen in the lung.
    1 context sentence
    Summary · context
    Utilizing C57BL/6J mice, we assessed the effect of chronic intranasal Kp-10 exposure on mixed allergen (MA)-induced mouse model of asthma.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with mixed allergen-induced asthma, Kp-10 exposure significantly reduced MA-induced soluble collagen in the lung.

    In plain wordsIn mice with allergic asthma, kisspeptin‑10 reduced the extra lung collagen caused by the allergen.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseSoluble collagen in the lung
    Study

    mousen: not reported in source

    C57BL/6J mice with mixed allergen (MA)-induced asthma
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated · intranasal · chronicAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, biochemical and histological studies showed Kp-10 exposure significantly reduced MA-induced smooth muscle mass and soluble collagen in the lung.
    1 context sentence
    Summary · context
    Utilizing C57BL/6J mice, we assessed the effect of chronic intranasal Kp-10 exposure on mixed allergen (MA)-induced mouse model of asthma.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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