Double-network hydrogel enhanced by SS31-loaded mesoporous polydopamine nanoparticles: Symphonic collaboration of near-infrared photothermal antibacterial effect and mitochondrial maintenance for full-thickness wound healing in diabetes mellitus.

Deng QS, Gao Y, Rui BY, Li XR, Liu PL, Han ZY, Wei ZY, Zhang CR, Wang F, Dawes H, Zhu TH, Tao SC, Guo SC

Bioactive materials21 Apr 2023Cited by 101 (Europe PMC)

PMID37152712PMCIDPMC10160601DOI10.1016/j.bioactmat.2023.04.004PepBankPUB-37152712

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Elamipretide (SS-31).

01AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats with full-thickness skin defects, the SS31-loaded hydrogel promoted macrophage M2 polarization.
In plain wordsIn diabetic rats, a wound hydrogel with SS31 and other active parts increased a healing-type macrophage state.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseMacrophage M2 polarization
Study
ratn: not reported in source
Diabetic rat full thickness skin defect model
Outcome group
Immune response · Skin and wound
Source sentences
Summary
In addition, in a diabetic rat full thickness skin defect model, the FH-M@S hydrogel promoted macrophage M2 polarization, collagen deposition, neovascularization and wound healing.
1 context sentence(design, population, supporting numbers)
Summary · context
To solve these issues, we developed a double-network hydrogel, constructed with pluronic F127 diacrylate (F127DA) and hyaluronic acid methacrylate (HAMA), and enhanced by SS31-loaded mesoporous polydopamine nanoparticles (MPDA NPs).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3715271201
02AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats with full-thickness skin defects, the SS31-loaded hydrogel promoted collagen deposition.
In plain wordsIn diabetic rats, a wound hydrogel with SS31 and other active parts increased collagen in the wound.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseCollagen deposition
Study
ratn: not reported in source
Diabetic rat full thickness skin defect model
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
In addition, in a diabetic rat full thickness skin defect model, the FH-M@S hydrogel promoted macrophage M2 polarization, collagen deposition, neovascularization and wound healing.
1 context sentence(design, population, supporting numbers)
Summary · context
To solve these issues, we developed a double-network hydrogel, constructed with pluronic F127 diacrylate (F127DA) and hyaluronic acid methacrylate (HAMA), and enhanced by SS31-loaded mesoporous polydopamine nanoparticles (MPDA NPs).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3715271202
03AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats with full-thickness skin defects, the SS31-loaded hydrogel promoted neovascularization.
In plain wordsIn diabetic rats, a wound hydrogel with SS31 and other active parts increased new blood vessel growth in the wound.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseNeovascularization
Study
ratn: not reported in source
Diabetic rat full thickness skin defect model
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
In addition, in a diabetic rat full thickness skin defect model, the FH-M@S hydrogel promoted macrophage M2 polarization, collagen deposition, neovascularization and wound healing.
1 context sentence(design, population, supporting numbers)
Summary · context
To solve these issues, we developed a double-network hydrogel, constructed with pluronic F127 diacrylate (F127DA) and hyaluronic acid methacrylate (HAMA), and enhanced by SS31-loaded mesoporous polydopamine nanoparticles (MPDA NPs).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3715271203
04AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats with full-thickness skin defects, the SS31-loaded hydrogel promoted wound healing.
In plain wordsIn diabetic rats, a wound hydrogel with SS31 and other active parts improved wound healing.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseWound healing
Study
ratn: not reported in source
Diabetic rat full thickness skin defect model
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
In addition, in a diabetic rat full thickness skin defect model, the FH-M@S hydrogel promoted macrophage M2 polarization, collagen deposition, neovascularization and wound healing.
1 context sentence(design, population, supporting numbers)
Summary · context
To solve these issues, we developed a double-network hydrogel, constructed with pluronic F127 diacrylate (F127DA) and hyaluronic acid methacrylate (HAMA), and enhanced by SS31-loaded mesoporous polydopamine nanoparticles (MPDA NPs).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3715271204
05LabNot a test of Elamipretide (SS-31) aloneOther designOther
The hydrogel with SS31-loaded nanoparticles had adhesion, superior biocompatibility and mechanical properties, with sustained release of the nanoparticles.
In plain wordsIn lab tests, the hydrogel stuck to wounds, was compatible with biological material and released its particles slowly.
Peptide
Elamipretide (SS-31)
Outcome
Not applicableHydrogel adhesion, biocompatibility and mechanical properties
Study
n: not reported in source
Outcome group
Formulation, delivery and stability · Pharmacology
Source sentences
Summary
This F127DA/HAMA-MPDA@SS31 (FH-M@S) hydrogel has characteristics of adhesion, superior biocompatibility and mechanical properties which can adapt to irregular wounds at different body sites and provide sustained release of MPDA@SS31 (M@S) NPs.
1 context sentence(design, population, supporting numbers)
Summary · context
To solve these issues, we developed a double-network hydrogel, constructed with pluronic F127 diacrylate (F127DA) and hyaluronic acid methacrylate (HAMA), and enhanced by SS31-loaded mesoporous polydopamine nanoparticles (MPDA NPs).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3715271205

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.