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Study · Animal study (in vivo) · mouse · 2023

5 results

Immunohistochemistry of Leukemia Inhibitory Factor and Integrin αVβ3 in Mouse Endometrium Following Kisspeptin-54 Ovulation Trigger.

Abdelkareem AO, Iews MS, Ait-Allah AS, Rasheed SM, Helmy YA, Habte R, Abdelhafez FF, Bedaiwy MA

Reproductive sciences (Thousand Oaks, Calif.)1 May 2023Cited by 1 (Europe PMC)

PMID37126206 (opens in a new tab)DOI10.1007/s43032-023-01243-7 (opens in a new tab)PepBankPUB-37126206
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In superovulated mice, a KP-54 trigger gave significantly higher LIF expression in endometrial glandular epithelium than PBS.

    In plain wordsIn mice, a kisspeptin‑54 trigger raised the implantation marker LIF in the uterine lining more than PBS did.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseLIF expression in endometrial glandular epithelium
    Study

    mousen = 10

    superovulated C57BL/6J female mice
    Comparator
    PBS (placebo)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3 nmolAs given in this study (mouse).

    Source sentences

    Summary
    LIF expression was significantly higher in GE and SCs of mice triggered with KP-54 compared to placebo (P = .009 for both), but only higher than hCG trigger group in SCs (P = .009).
    2 context sentences
    Summary · context
    C57BL/6 J female mice were superovulated via intraperitoneal injection of 5 International Units (IU) pregnant mare serum gonadotrophin (day 1).
    Summary · context
    Forty-eight hours later, mice (5/group) were injected with phosphate-buffered saline (PBS) (group A), 5 IU human chorionic gonadotrophin (hCG) (group B), or 3 nmol KP-54 (group C).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In superovulated mice, a KP-54 trigger gave significantly higher LIF expression in endometrial stromal cells than PBS.

    In plain wordsIn mice, a kisspeptin‑54 trigger raised the implantation marker LIF in uterine stromal cells more than PBS did.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseLIF expression in endometrial stromal cells
    Study

    mousen = 10

    superovulated C57BL/6J female mice
    Comparator
    PBS (placebo)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3 nmolAs given in this study (mouse).

    Source sentences

    Summary
    LIF expression was significantly higher in GE and SCs of mice triggered with KP-54 compared to placebo (P = .009 for both), but only higher than hCG trigger group in SCs (P = .009).
    2 context sentences
    Summary · context
    C57BL/6 J female mice were superovulated via intraperitoneal injection of 5 International Units (IU) pregnant mare serum gonadotrophin (day 1).
    Summary · context
    Forty-eight hours later, mice (5/group) were injected with phosphate-buffered saline (PBS) (group A), 5 IU human chorionic gonadotrophin (hCG) (group B), or 3 nmol KP-54 (group C).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In superovulated mice, a KP-54 trigger gave higher LIF expression in endometrial stromal cells than an hCG trigger.

    In plain wordsIn mice, a kisspeptin‑54 trigger raised LIF in uterine stromal cells more than an hCG trigger did.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseLIF expression in stromal cells versus hCG trigger
    Study

    mousen = 10

    superovulated C57BL/6J female mice
    Comparator
    hCG trigger
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3 nmolAs given in this study (mouse).

    Source sentences

    Summary
    but only higher than hCG trigger group in SCs (P = .009).
    2 context sentences
    Summary · context
    C57BL/6 J female mice were superovulated via intraperitoneal injection of 5 International Units (IU) pregnant mare serum gonadotrophin (day 1).
    Summary · context
    Forty-eight hours later, mice (5/group) were injected with phosphate-buffered saline (PBS) (group A), 5 IU human chorionic gonadotrophin (hCG) (group B), or 3 nmol KP-54 (group C).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In superovulated mice, LIF expression in endometrial glandular epithelium after a KP-54 trigger was not higher than after an hCG trigger.

    In plain wordsIn mice, a kisspeptin‑54 trigger did not raise LIF in the uterine gland lining more than an hCG trigger did.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeLIF expression in glandular epithelium versus hCG trigger
    Study

    mousen = 10

    superovulated C57BL/6J female mice
    Comparator
    hCG trigger
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3 nmolAs given in this study (mouse).

    Source sentences

    Summary
    LIF expression was significantly higher in GE and SCs of mice triggered with KP-54 compared to placebo (P = .009 for both), but only higher than hCG trigger group in SCs (P = .009).
    2 context sentences
    Summary · context
    C57BL/6 J female mice were superovulated via intraperitoneal injection of 5 International Units (IU) pregnant mare serum gonadotrophin (day 1).
    Summary · context
    Forty-eight hours later, mice (5/group) were injected with phosphate-buffered saline (PBS) (group A), 5 IU human chorionic gonadotrophin (hCG) (group B), or 3 nmol KP-54 (group C).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In superovulated mice, a KP-54 trigger gave significantly higher integrin alphaVbeta3 expression in endometrial stromal cells than PBS.

    In plain wordsIn mice, a kisspeptin‑54 trigger raised the implantation marker integrin alphaVbeta3 in uterine stromal cells more than PBS did.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseIntegrin alphaVbeta3 expression in endometrial stromal cells
    Study

    mousen = 10

    superovulated C57BL/6J female mice
    Comparator
    PBS (placebo)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3 nmolAs given in this study (mouse).

    Source sentences

    Summary
    Meanwhile, ITG αVβ3 expression was significantly higher in SCs of mice triggered with KP-54 compared to placebo (P = .028).
    2 context sentences
    Summary · context
    C57BL/6 J female mice were superovulated via intraperitoneal injection of 5 International Units (IU) pregnant mare serum gonadotrophin (day 1).
    Summary · context
    Forty-eight hours later, mice (5/group) were injected with phosphate-buffered saline (PBS) (group A), 5 IU human chorionic gonadotrophin (hCG) (group B), or 3 nmol KP-54 (group C).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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