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Study · Animal study (in vivo) · 2023

7 results

Elamipretide reduces pyroptosis and improves functional recovery after spinal cord injury.

Jiang W, He F, Ding G, Wu J, Wu J

CNS neuroscience & therapeutics20 Apr 2023Cited by 16 (Europe PMC)

PMID37081763 (opens in a new tab)PMCIDPMC10493668 (opens in a new tab)DOI10.1111/cns.14221 (opens in a new tab)PepBankPUB-37081763
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Summary

AimsElamipretide (EPT), a novel mitochondria-targeted peptide, has been shown to be protective in a range of diseases. However, the effect of EPT in spinal cord injury (SCI) has yet to be elucidated. We aimed to investigate whether EPT would inhibit pyroptosis and protect against SCI.MethodsAfter establishing the SCI model, we determined the biochemical and morphological changes associated with pyroptosis, including neuronal cell death, proinflammatory cytokine expression, and signal pathway levels. Furthermore, mitochondrial function was assessed with flow cytometry, quantitative real-time polymerase chain reaction, and western blot.ResultsHere, we demonstrate that EPT improved locomotor functional recovery following SCI as well as reduced neuronal loss. Moreover, EPT inhibited nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome activation and pyroptosis occurrence and decreased pro-inflammatory cytokines levels following SCI. Furthermore, EPT alleviated mitochondrial dysfunction and reduced mitochondrial reactive oxygen species level.ConclusionEPT treatment may protect against SCI via inhibition of pyroptosis.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In a spinal cord injury model, elamipretide improved locomotor functional recovery.

    In plain wordsIn animals with spinal cord injury, elamipretide improved recovery of movement.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseLocomotor functional recovery
    Study

    n: not reported in source

    Spinal cord injury model
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we demonstrate that EPT improved locomotor functional recovery following SCI as well as reduced neuronal loss.
    1 context sentence
    Summary · context
    After establishing the SCI model, we determined the biochemical and morphological changes associated with pyroptosis, including neuronal cell death, proinflammatory cytokine expression, and signal pathway levels.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In a spinal cord injury model, elamipretide reduced neuronal loss.

    In plain wordsIn animals with spinal cord injury, elamipretide reduced the loss of nerve cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNeuronal loss
    Study

    n: not reported in source

    Spinal cord injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we demonstrate that EPT improved locomotor functional recovery following SCI as well as reduced neuronal loss.
    1 context sentence
    Summary · context
    After establishing the SCI model, we determined the biochemical and morphological changes associated with pyroptosis, including neuronal cell death, proinflammatory cytokine expression, and signal pathway levels.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In a spinal cord injury model, elamipretide inhibited NLRP3 inflammasome activation.

    In plain wordsIn animals with spinal cord injury, elamipretide reduced activation of the NLRP3 inflammasome.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNLRP3 inflammasome activation
    Study

    n: not reported in source

    Spinal cord injury model
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, EPT inhibited nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome activation and pyroptosis occurrence and decreased pro-inflammatory cytokines levels following SCI.
    1 context sentence
    Summary · context
    After establishing the SCI model, we determined the biochemical and morphological changes associated with pyroptosis, including neuronal cell death, proinflammatory cytokine expression, and signal pathway levels.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In a spinal cord injury model, elamipretide inhibited the occurrence of pyroptosis.

    In plain wordsIn animals with spinal cord injury, elamipretide reduced a form of inflammatory cell death.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePyroptosis
    Study

    n: not reported in source

    Spinal cord injury model
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, EPT inhibited nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome activation and pyroptosis occurrence and decreased pro-inflammatory cytokines levels following SCI.
    1 context sentence
    Summary · context
    After establishing the SCI model, we determined the biochemical and morphological changes associated with pyroptosis, including neuronal cell death, proinflammatory cytokine expression, and signal pathway levels.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In a spinal cord injury model, elamipretide decreased pro-inflammatory cytokine levels.

    In plain wordsIn animals with spinal cord injury, elamipretide lowered inflammation signals.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePro-inflammatory cytokine levels
    Study

    n: not reported in source

    Spinal cord injury model
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, EPT inhibited nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome activation and pyroptosis occurrence and decreased pro-inflammatory cytokines levels following SCI.
    1 context sentence
    Summary · context
    After establishing the SCI model, we determined the biochemical and morphological changes associated with pyroptosis, including neuronal cell death, proinflammatory cytokine expression, and signal pathway levels.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In a spinal cord injury model, elamipretide alleviated mitochondrial dysfunction.

    In plain wordsIn animals with spinal cord injury, elamipretide reduced mitochondrial damage.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial dysfunction
    Study

    n: not reported in source

    Spinal cord injury model
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, EPT alleviated mitochondrial dysfunction and reduced mitochondrial reactive oxygen species level.
    1 context sentence
    Summary · context
    After establishing the SCI model, we determined the biochemical and morphological changes associated with pyroptosis, including neuronal cell death, proinflammatory cytokine expression, and signal pathway levels.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In a spinal cord injury model, elamipretide reduced the level of mitochondrial reactive oxygen species.

    In plain wordsIn animals with spinal cord injury, elamipretide lowered reactive oxygen species in mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial ROS level
    Study

    n: not reported in source

    Spinal cord injury model
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, EPT alleviated mitochondrial dysfunction and reduced mitochondrial reactive oxygen species level.
    1 context sentence
    Summary · context
    After establishing the SCI model, we determined the biochemical and morphological changes associated with pyroptosis, including neuronal cell death, proinflammatory cytokine expression, and signal pathway levels.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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