In cultured rat sensory neurons, Cortexin concentration-dependently attenuated the high-glucose-induced decrease in Cell Index AUC.
In plain wordsIn cells from rat sensory neurons, Cortexin increased Cell Index AUC compared with high glucose alone.
- Outcome
- IncreaseCell Index AUC under high glucose
- Study
ratn: not reported in source
Primary cultured dorsal root ganglion sensory neurons- Comparator
- High glucose without Cortexin
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 2-40 µg/mLAs given in this study (rat).
Measurements
- Cell Index AUC
- 0.66 relative units
- high glucose plus Cortexin 40 µg/mL
- Cell Index AUC
- 0.18 relative units
- high glucose
Source sentences
Co-treatment with Cortexin® attenuated this HpG-induced effect, in a concentration-dependent manner (NG: 1.00 ± 0.00 vs. HG: 0.18 ± 0.02, p < 0.05; and HpG + Cortexin® [40 µg/mL]: 0.66 ± 0.17, p = 0.002 versus HpG).
2 context sentences(design, population, supporting numbers)
The aim of this study was to investigate whether Cortexin®, a brain peptide-containing agent, has any mitigating effect on high glucose-induced neuropathy, using primary cultured rat sensory neurons.
After allowing for 24 h for cell adhesion and recovery from acute enzymatic trauma, neurons were exposed to high glucose (HpG) in the absence and presence of different concentrations of Cortexin® (2-40 µg/mL).