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Study · Animal study (in vivo) · mouse · 2023

14 results

PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS.

Wagner ML, Ammann A, Piraino G, Wolfe V, O'Connor M, Lahni P, Ziady A, Zingarelli B

Shock (Augusta, Ga.)21 Apr 2023Cited by 4 (Europe PMC)

PMID37079467 (opens in a new tab)PMCIDPMC10523894 (opens in a new tab)DOI10.1097/shk.0000000000002134 (opens in a new tab)PepBankPUB-37079467
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with hemorrhagic shock, humanin-G improved lung injury in both wild-type and AMPKα1 knockout mice.

    In plain wordsIn mice with hemorrhagic shock, humanin-G improved lung injury compared with vehicle.

    Peptide
    Humanin
    Outcome
    DecreaseLung injury
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Comparator
    Vehicle
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with humanin-G improved lung injury, mean arterial blood pressure, and survival in both WT and KO mice, without affecting systemic cytokine or humanin levels.
    2 context sentences
    Summary · context
    AMPKα1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution.
    Summary · context
    In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscitation; in survival studies, mice were treated with PEGylated humanin-G and monitored for 7 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with hemorrhagic shock, humanin-G improved mean arterial blood pressure in both wild-type and AMPKα1 knockout mice.

    In plain wordsIn mice with hemorrhagic shock, humanin-G improved blood pressure compared with vehicle.

    Peptide
    Humanin
    Outcome
    IncreaseMean arterial blood pressure
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Comparator
    Vehicle
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with humanin-G improved lung injury, mean arterial blood pressure, and survival in both WT and KO mice, without affecting systemic cytokine or humanin levels.
    2 context sentences
    Summary · context
    AMPKα1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution.
    Summary · context
    In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscitation; in survival studies, mice were treated with PEGylated humanin-G and monitored for 7 days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with hemorrhagic shock, PEGylated humanin-G improved survival in both wild-type and AMPKα1 knockout mice.

    In plain wordsIn mice with hemorrhagic shock, humanin-G improved survival compared with vehicle.

    Peptide
    Humanin
    Outcome
    IncreaseSurvival over 7 days
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Comparator
    Vehicle
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with humanin-G improved lung injury, mean arterial blood pressure, and survival in both WT and KO mice, without affecting systemic cytokine or humanin levels.
    2 context sentences
    Summary · context
    AMPKα1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution.
    Summary · context
    In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscitation; in survival studies, mice were treated with PEGylated humanin-G and monitored for 7 days.
  4. 04AnimalAnimal study (in vivo)Mechanism

    Humanin-G did not change systemic cytokine or humanin levels in mice with hemorrhagic shock.

    In plain wordsIn mice with hemorrhagic shock, humanin-G did not change blood cytokine or humanin levels.

    Peptide
    Humanin
    Outcome
    No significant changeSystemic cytokine and humanin levels
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    without affecting systemic cytokine or humanin levels.
    2 context sentences
    Summary · context
    AMPKα1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution.
    Summary · context
    In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscitation; in survival studies, mice were treated with PEGylated humanin-G and monitored for 7 days.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In AMPKα1 knockout mice with hemorrhagic shock, humanin-G ameliorated cardiac mitochondrial damage.

    In plain wordsIn knockout mice with hemorrhagic shock, humanin-G reduced heart mitochondrial damage compared with vehicle.

    Peptide
    Humanin
    Outcome
    DecreaseCardiac mitochondrial damage in knockout mice
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Comparator
    Vehicle
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Humanin-G also ameliorated cardiac mitochondrial damage
    2 context sentences
    Summary · context
    AMPKα1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution.
    Summary · context
    In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscitation; in survival studies, mice were treated with PEGylated humanin-G and monitored for 7 days.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In AMPKα1 knockout mice with hemorrhagic shock, humanin-G increased adenosine triphosphate levels.

    In plain wordsIn knockout mice with hemorrhagic shock, humanin-G raised cell energy (ATP) levels compared with vehicle.

    Peptide
    Humanin
    Outcome
    IncreaseATP levels in knockout mice
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Comparator
    Vehicle
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Humanin-G also ameliorated cardiac mitochondrial damage and increased adenosine triphosphate levels in KO mice.
    2 context sentences
    Summary · context
    AMPKα1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution.
    Summary · context
    In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscitation; in survival studies, mice were treated with PEGylated humanin-G and monitored for 7 days.
  7. 07AnimalAnimal study (in vivo)Mechanism

    Humanin-G was associated with lung cytoplasmic and nuclear STAT3 activation in an AMPKα1-independent manner.

    In plain wordsIn mice with hemorrhagic shock, humanin-G was linked to activation of the STAT3 pathway in the lung.

    Peptide
    Humanin
    Outcome
    IncreaseLung STAT3 activation
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Beneficial effects of humanin-G were associated with lung cytoplasmic and nuclear activation of the signal transducer and activator of transcription-3 (STAT3) in AMPKα1-independent manner
    2 context sentences
    Summary · context
    AMPKα1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution.
    Summary · context
    In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscitation; in survival studies, mice were treated with PEGylated humanin-G and monitored for 7 days.
  8. 08AnimalAnimal study (in vivo)Mechanism

    Humanin-G had marginal or no effects on mitochondrial STAT3 and complex I subunit GRIM-19.

    In plain wordsIn mice with hemorrhagic shock, humanin-G had little or no effect on mitochondrial STAT3 or GRIM-19.

    Peptide
    Humanin
    Outcome
    No significant changeMitochondrial STAT3 and complex I subunit GRIM-19
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Comparator
    Vehicle
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    with marginal or no effects on mitochondrial STAT3 and complex I subunit GRIM-19.
    2 context sentences
    Summary · context
    AMPKα1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution.
    Summary · context
    In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscitation; in survival studies, mice were treated with PEGylated humanin-G and monitored for 7 days.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 09AnimalEndogenous levelAnimal study (in vivo)Other

    Circulating levels of the body's own humanin increased during hemorrhagic shock in an AMPKα1-independent manner.

    In plain wordsIn mice, the body's own humanin rose in the blood during hemorrhagic shock.

    Peptide
    Humanin
    Outcome
    IncreaseCirculating endogenous humanin during hemorrhagic shock
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Outcome group
    Aging markers · Endocrine and hormones

    Source sentences

    Summary
    circulating levels of humanin increase during hemorrhagic shock in AMPKα1-independent fashion

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone5

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 10AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    Compared with vehicle wild-type mice, AMPKα1 knockout mice had severe hypotension during hemorrhagic shock.

    In plain wordsIn mice with hemorrhagic shock, knockout of the AMPKα1 gene led to severe low blood pressure.

    Peptide
    Humanin
    Outcome
    DecreaseBlood pressure in AMPKα1 knockout mice
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Comparator
    Vehicle wild-type group
    Outcome group
    Blood pressure · Cardiovascular

    Source sentences

    Summary
    Compared with the vehicle WT group, KO mice exhibited severe hypotension
    2 context sentences
    Summary · context
    AMPKα1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution.
    Summary · context
    In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscitation; in survival studies, mice were treated with PEGylated humanin-G and monitored for 7 days.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 11AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    Compared with vehicle wild-type mice, AMPKα1 knockout mice had more cardiac mitochondrial damage during hemorrhagic shock.

    In plain wordsIn mice with hemorrhagic shock, knockout of the AMPKα1 gene led to more heart mitochondrial damage.

    Peptide
    Humanin
    Outcome
    IncreaseCardiac mitochondrial damage in AMPKα1 knockout mice
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Comparator
    Vehicle wild-type group
    Outcome group
    Mitochondrial function · Cardiovascular

    Source sentences

    Summary
    cardiac mitochondrial damage, and higher plasma levels of Th17 cytokines but had similar lung injury and similar plasma elevation of endogenous humanin.
    2 context sentences
    Summary · context
    AMPKα1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution.
    Summary · context
    In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscitation; in survival studies, mice were treated with PEGylated humanin-G and monitored for 7 days.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 12AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    Compared with vehicle wild-type mice, AMPKα1 knockout mice had higher plasma Th17 cytokines during hemorrhagic shock.

    In plain wordsIn mice with hemorrhagic shock, knockout of the AMPKα1 gene led to higher blood levels of inflammation signals.

    Peptide
    Humanin
    Outcome
    IncreasePlasma Th17 cytokines in AMPKα1 knockout mice
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Comparator
    Vehicle wild-type group
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    higher plasma levels of Th17 cytokines but had similar lung injury and similar plasma elevation of endogenous humanin.
    2 context sentences
    Summary · context
    AMPKα1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution.
    Summary · context
    In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscitation; in survival studies, mice were treated with PEGylated humanin-G and monitored for 7 days.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 13AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    Compared with vehicle wild-type mice, AMPKα1 knockout mice had similar lung injury after hemorrhagic shock.

    In plain wordsIn mice with hemorrhagic shock, knockout of the AMPKα1 gene did not change lung injury.

    Peptide
    Humanin
    Outcome
    No significant changeLung injury in AMPKα1 knockout mice
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Comparator
    Vehicle wild-type group
    Outcome group
    Lung injury and fibrosis · Respiratory

    Source sentences

    Summary
    similar lung injury and similar plasma elevation of endogenous humanin.
    2 context sentences
    Summary · context
    AMPKα1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution.
    Summary · context
    In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscitation; in survival studies, mice were treated with PEGylated humanin-G and monitored for 7 days.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  5. 14AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    Compared with vehicle wild-type mice, AMPKα1 knockout mice had a similar plasma elevation of endogenous humanin after hemorrhagic shock.

    In plain wordsIn mice with hemorrhagic shock, knockout of the AMPKα1 gene did not change the rise in the body's own humanin.

    Peptide
    Humanin
    Outcome
    No significant changePlasma endogenous humanin elevation in AMPKα1 knockout mice
    Study

    mousen: not reported in source

    Hemorrhagic shock in female mice
    Comparator
    Vehicle wild-type group
    Outcome group
    Aging markers · Endocrine and hormones

    Source sentences

    Summary
    similar plasma elevation of endogenous humanin.
    2 context sentences
    Summary · context
    AMPKα1 wild-type (WT) and knockout (KO) female mice were subjected to hemorrhagic shock followed by resuscitation with blood and lactated Ringer's solution.
    Summary · context
    In short-term studies, mice were treated with humanin-G or vehicle and sacrificed at 3 h after resuscitation; in survival studies, mice were treated with PEGylated humanin-G and monitored for 7 days.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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