Carnosine-Based Reversal of Diabetes-Associated Cognitive Decline via Activation of the Akt/mTOR Pathway and Modulation of Autophagy in a Rat Model of Type 2 Diabetes Mellitus.

Ndolo RO, Yu L, Zhao Y, Lu J, Wang G, Zhao X, Ren Y, Yang J

Dementia and geriatric cognitive disorders19 Apr 2023Cited by 14 (Europe PMC)

PMID37075707DOI10.1159/000530605PepBankPUB-37075707

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine did not significantly change body weight versus untreated diabetic rats.
In plain wordsIn diabetic rats, carnosine did not significantly change body weight versus untreated diabetic rats.
Peptide
L-carnosine
Outcome
No significant changeBody weight
Study
ratn: not reported in source
HFD/STZ-induced diabetes in Sprague-Dawley rats
Comparator
Untreated HFD/STZ diabetic rats
Outcome group
Body weight · Metabolic and weight
Studied dose
100, 300, and 900 mg/kg · intragastric · 12 weeksAs given in this study (rat).
Source sentences
Summary
However, there were no significant differences in body weight and blood glucose levels between carnosine-treated and -untreated HFD-STZ-induced diabetic rats.
2 context sentences(design, population, supporting numbers)
Summary · context
A high-fat diet (HFD) and one intraperitoneal injection of 30 mg/kg streptozotocin (STZ) were used to induce type 2 diabetes mellitus in Sprague-Dawley rats.
Summary · context
The rats were randomly divided into five groups: control (CON), HFD/STZ, and three intragastric carnosine treatment groups receiving low (100 mg/kg), medium (300 mg/kg), and high (900 mg/kg) doses over 12 weeks.
Report a problemFND-3707570701
02AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine did not significantly change blood glucose versus untreated diabetic rats.
In plain wordsIn diabetic rats, carnosine did not significantly change blood glucose versus untreated diabetic rats.
Peptide
L-carnosine
Outcome
No significant changeBlood glucose
Study
ratn: not reported in source
HFD/STZ-induced diabetes in Sprague-Dawley rats
Comparator
Untreated HFD/STZ diabetic rats
Outcome group
Glycemic control · Metabolic and weight
Studied dose
100, 300, and 900 mg/kg · intragastric · 12 weeksAs given in this study (rat).
Source sentences
Summary
However, there were no significant differences in body weight and blood glucose levels between carnosine-treated and -untreated HFD-STZ-induced diabetic rats.
2 context sentences(design, population, supporting numbers)
Summary · context
A high-fat diet (HFD) and one intraperitoneal injection of 30 mg/kg streptozotocin (STZ) were used to induce type 2 diabetes mellitus in Sprague-Dawley rats.
Summary · context
The rats were randomly divided into five groups: control (CON), HFD/STZ, and three intragastric carnosine treatment groups receiving low (100 mg/kg), medium (300 mg/kg), and high (900 mg/kg) doses over 12 weeks.
Report a problemFND-3707570702
03AnimalAnimal study (in vivo)Mechanism
In diabetic rats, carnosine increased hippocampal SOD activity versus untreated diabetic rats in a dose-dependent manner.
In plain wordsIn diabetic rats, carnosine increased hippocampal SOD activity versus untreated diabetic rats as dose increased.
Peptide
L-carnosine
Outcome
IncreaseHippocampal SOD activity
Study
ratn: not reported in source
HFD/STZ-induced diabetes in Sprague-Dawley rats
Comparator
Untreated HFD/STZ diabetic rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
100, 300, and 900 mg/kg · intragastric · 12 weeksAs given in this study (rat).
Source sentences
Summary
Compared to those in the HFD/STZ group, carnosine increased SOD activity and decreased MDA levels, increased hippocampal carnosine concentration, increased p-Akt and p-mTOR expression, decreased LC3B and P62 expression, alleviated neuronal injuries, and improved cognitive performance in a dose-dependent manner.
2 context sentences(design, population, supporting numbers)
Summary · context
A high-fat diet (HFD) and one intraperitoneal injection of 30 mg/kg streptozotocin (STZ) were used to induce type 2 diabetes mellitus in Sprague-Dawley rats.
Summary · context
The rats were randomly divided into five groups: control (CON), HFD/STZ, and three intragastric carnosine treatment groups receiving low (100 mg/kg), medium (300 mg/kg), and high (900 mg/kg) doses over 12 weeks.
Report a problemFND-3707570703
04AnimalAnimal study (in vivo)Mechanism
In diabetic rats, carnosine decreased hippocampal MDA levels versus untreated diabetic rats in a dose-dependent manner.
In plain wordsIn diabetic rats, carnosine decreased hippocampal MDA levels versus untreated diabetic rats as dose increased.
Peptide
L-carnosine
Outcome
DecreaseHippocampal MDA
Study
ratn: not reported in source
HFD/STZ-induced diabetes in Sprague-Dawley rats
Comparator
Untreated HFD/STZ diabetic rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
100, 300, and 900 mg/kg · intragastric · 12 weeksAs given in this study (rat).
Source sentences
Summary
Compared to those in the HFD/STZ group, carnosine increased SOD activity and decreased MDA levels, increased hippocampal carnosine concentration, increased p-Akt and p-mTOR expression, decreased LC3B and P62 expression, alleviated neuronal injuries, and improved cognitive performance in a dose-dependent manner.
2 context sentences(design, population, supporting numbers)
Summary · context
A high-fat diet (HFD) and one intraperitoneal injection of 30 mg/kg streptozotocin (STZ) were used to induce type 2 diabetes mellitus in Sprague-Dawley rats.
Summary · context
The rats were randomly divided into five groups: control (CON), HFD/STZ, and three intragastric carnosine treatment groups receiving low (100 mg/kg), medium (300 mg/kg), and high (900 mg/kg) doses over 12 weeks.
Report a problemFND-3707570704
05AnimalAnimal study (in vivo)Pharmacokinetics
In diabetic rats, carnosine increased hippocampal carnosine concentration versus untreated diabetic rats in a dose-dependent manner.
In plain wordsIn diabetic rats, carnosine increased hippocampal carnosine concentration versus untreated diabetic rats as dose increased.
Peptide
L-carnosine
Outcome
IncreaseHippocampal carnosine concentration
Study
ratn: not reported in source
HFD/STZ-induced diabetes in Sprague-Dawley rats
Comparator
Untreated HFD/STZ diabetic rats
Outcome group
Pharmacokinetics · Nervous system and cognition
Studied dose
100, 300, and 900 mg/kg · intragastric · 12 weeksAs given in this study (rat).
Source sentences
Summary
Compared to those in the HFD/STZ group, carnosine increased SOD activity and decreased MDA levels, increased hippocampal carnosine concentration, increased p-Akt and p-mTOR expression, decreased LC3B and P62 expression, alleviated neuronal injuries, and improved cognitive performance in a dose-dependent manner.
2 context sentences(design, population, supporting numbers)
Summary · context
A high-fat diet (HFD) and one intraperitoneal injection of 30 mg/kg streptozotocin (STZ) were used to induce type 2 diabetes mellitus in Sprague-Dawley rats.
Summary · context
The rats were randomly divided into five groups: control (CON), HFD/STZ, and three intragastric carnosine treatment groups receiving low (100 mg/kg), medium (300 mg/kg), and high (900 mg/kg) doses over 12 weeks.
Report a problemFND-3707570705
06AnimalAnimal study (in vivo)Mechanism
In diabetic rats, carnosine increased hippocampal p-Akt expression versus untreated diabetic rats in a dose-dependent manner.
In plain wordsIn diabetic rats, carnosine increased hippocampal p-Akt expression versus untreated diabetic rats as dose increased.
Peptide
L-carnosine
Outcome
Increasep-Akt expression
Study
ratn: not reported in source
HFD/STZ-induced diabetes in Sprague-Dawley rats
Comparator
Untreated HFD/STZ diabetic rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
100, 300, and 900 mg/kg · intragastric · 12 weeksAs given in this study (rat).
Source sentences
Summary
Compared to those in the HFD/STZ group, carnosine increased SOD activity and decreased MDA levels, increased hippocampal carnosine concentration, increased p-Akt and p-mTOR expression, decreased LC3B and P62 expression, alleviated neuronal injuries, and improved cognitive performance in a dose-dependent manner.
2 context sentences(design, population, supporting numbers)
Summary · context
A high-fat diet (HFD) and one intraperitoneal injection of 30 mg/kg streptozotocin (STZ) were used to induce type 2 diabetes mellitus in Sprague-Dawley rats.
Summary · context
The rats were randomly divided into five groups: control (CON), HFD/STZ, and three intragastric carnosine treatment groups receiving low (100 mg/kg), medium (300 mg/kg), and high (900 mg/kg) doses over 12 weeks.
Report a problemFND-3707570706
07AnimalAnimal study (in vivo)Mechanism
In diabetic rats, carnosine increased hippocampal p-mTOR expression versus untreated diabetic rats in a dose-dependent manner.
In plain wordsIn diabetic rats, carnosine increased hippocampal p-mTOR expression versus untreated diabetic rats as dose increased.
Peptide
L-carnosine
Outcome
Increasep-mTOR expression
Study
ratn: not reported in source
HFD/STZ-induced diabetes in Sprague-Dawley rats
Comparator
Untreated HFD/STZ diabetic rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
100, 300, and 900 mg/kg · intragastric · 12 weeksAs given in this study (rat).
Source sentences
Summary
Compared to those in the HFD/STZ group, carnosine increased SOD activity and decreased MDA levels, increased hippocampal carnosine concentration, increased p-Akt and p-mTOR expression, decreased LC3B and P62 expression, alleviated neuronal injuries, and improved cognitive performance in a dose-dependent manner.
2 context sentences(design, population, supporting numbers)
Summary · context
A high-fat diet (HFD) and one intraperitoneal injection of 30 mg/kg streptozotocin (STZ) were used to induce type 2 diabetes mellitus in Sprague-Dawley rats.
Summary · context
The rats were randomly divided into five groups: control (CON), HFD/STZ, and three intragastric carnosine treatment groups receiving low (100 mg/kg), medium (300 mg/kg), and high (900 mg/kg) doses over 12 weeks.
Report a problemFND-3707570707
08AnimalAnimal study (in vivo)Mechanism
In diabetic rats, carnosine decreased hippocampal LC3B expression versus untreated diabetic rats in a dose-dependent manner.
In plain wordsIn diabetic rats, carnosine decreased hippocampal LC3B expression versus untreated diabetic rats as dose increased.
Peptide
L-carnosine
Outcome
DecreaseLC3B expression
Study
ratn: not reported in source
HFD/STZ-induced diabetes in Sprague-Dawley rats
Comparator
Untreated HFD/STZ diabetic rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
100, 300, and 900 mg/kg · intragastric · 12 weeksAs given in this study (rat).
Source sentences
Summary
Compared to those in the HFD/STZ group, carnosine increased SOD activity and decreased MDA levels, increased hippocampal carnosine concentration, increased p-Akt and p-mTOR expression, decreased LC3B and P62 expression, alleviated neuronal injuries, and improved cognitive performance in a dose-dependent manner.
2 context sentences(design, population, supporting numbers)
Summary · context
A high-fat diet (HFD) and one intraperitoneal injection of 30 mg/kg streptozotocin (STZ) were used to induce type 2 diabetes mellitus in Sprague-Dawley rats.
Summary · context
The rats were randomly divided into five groups: control (CON), HFD/STZ, and three intragastric carnosine treatment groups receiving low (100 mg/kg), medium (300 mg/kg), and high (900 mg/kg) doses over 12 weeks.
Report a problemFND-3707570708
09AnimalAnimal study (in vivo)Mechanism
In diabetic rats, carnosine decreased hippocampal P62 expression versus untreated diabetic rats in a dose-dependent manner.
In plain wordsIn diabetic rats, carnosine decreased hippocampal P62 expression versus untreated diabetic rats as dose increased.
Peptide
L-carnosine
Outcome
DecreaseP62 expression
Study
ratn: not reported in source
HFD/STZ-induced diabetes in Sprague-Dawley rats
Comparator
Untreated HFD/STZ diabetic rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
100, 300, and 900 mg/kg · intragastric · 12 weeksAs given in this study (rat).
Source sentences
Summary
Compared to those in the HFD/STZ group, carnosine increased SOD activity and decreased MDA levels, increased hippocampal carnosine concentration, increased p-Akt and p-mTOR expression, decreased LC3B and P62 expression, alleviated neuronal injuries, and improved cognitive performance in a dose-dependent manner.
2 context sentences(design, population, supporting numbers)
Summary · context
A high-fat diet (HFD) and one intraperitoneal injection of 30 mg/kg streptozotocin (STZ) were used to induce type 2 diabetes mellitus in Sprague-Dawley rats.
Summary · context
The rats were randomly divided into five groups: control (CON), HFD/STZ, and three intragastric carnosine treatment groups receiving low (100 mg/kg), medium (300 mg/kg), and high (900 mg/kg) doses over 12 weeks.
Report a problemFND-3707570709
10AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine alleviated neuronal injury versus untreated diabetic rats in a dose-dependent manner.
In plain wordsIn diabetic rats, carnosine reduced nerve cell injury versus untreated diabetic rats as dose increased.
Peptide
L-carnosine
Outcome
DecreaseNeuronal injury
Study
ratn: not reported in source
HFD/STZ-induced diabetes in Sprague-Dawley rats
Comparator
Untreated HFD/STZ diabetic rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
100, 300, and 900 mg/kg · intragastric · 12 weeksAs given in this study (rat).
Source sentences
Summary
Compared to those in the HFD/STZ group, carnosine increased SOD activity and decreased MDA levels, increased hippocampal carnosine concentration, increased p-Akt and p-mTOR expression, decreased LC3B and P62 expression, alleviated neuronal injuries, and improved cognitive performance in a dose-dependent manner.
2 context sentences(design, population, supporting numbers)
Summary · context
A high-fat diet (HFD) and one intraperitoneal injection of 30 mg/kg streptozotocin (STZ) were used to induce type 2 diabetes mellitus in Sprague-Dawley rats.
Summary · context
The rats were randomly divided into five groups: control (CON), HFD/STZ, and three intragastric carnosine treatment groups receiving low (100 mg/kg), medium (300 mg/kg), and high (900 mg/kg) doses over 12 weeks.
Report a problemFND-3707570710
11AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine improved cognitive performance versus untreated diabetic rats in a dose-dependent manner.
In plain wordsIn diabetic rats, carnosine improved cognitive performance versus untreated diabetic rats as dose increased.
Peptide
L-carnosine
Outcome
IncreaseCognitive performance
Study
ratn: not reported in source
HFD/STZ-induced diabetes in Sprague-Dawley rats
Comparator
Untreated HFD/STZ diabetic rats
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
100, 300, and 900 mg/kg · intragastric · 12 weeksAs given in this study (rat).
Source sentences
Summary
Compared to those in the HFD/STZ group, carnosine increased SOD activity and decreased MDA levels, increased hippocampal carnosine concentration, increased p-Akt and p-mTOR expression, decreased LC3B and P62 expression, alleviated neuronal injuries, and improved cognitive performance in a dose-dependent manner.
2 context sentences(design, population, supporting numbers)
Summary · context
A high-fat diet (HFD) and one intraperitoneal injection of 30 mg/kg streptozotocin (STZ) were used to induce type 2 diabetes mellitus in Sprague-Dawley rats.
Summary · context
The rats were randomly divided into five groups: control (CON), HFD/STZ, and three intragastric carnosine treatment groups receiving low (100 mg/kg), medium (300 mg/kg), and high (900 mg/kg) doses over 12 weeks.
Report a problemFND-3707570711

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Carnosine-Based Reversal of Diabetes-Associated Cognitive Decline via Activation of the Akt/mTOR Pathway and Modulation of Autophagy in a Rat Model of Type 2 Diabetes Mellitus.

Summary

Results from this study11

Version history

Subjects

Publication types

MeSH terms

Keywords