In purified protein assays, thymosin β4 bound human β- and γ-actin with higher affinity than it bound α-actin.
In plain wordsIn lab tests, thymosin β4 bound two non-muscle actin types more tightly than it bound muscle actin.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- Not applicableBinding affinity to actin isoforms
- Study
n: not reported in source
Yeast-expressed human β- and γ-actin- Comparator
- α-actin
- Outcome group
- Receptor activity and mechanism · Pharmacology
- Studied dose
- Dose not stated
Source sentences
Notably, Tβ4 and profilin bind to β- or γ-actin with higher affinity than to α-actin, emphasizing the value of testing actin ligands with specific actin isoforms.
1 context sentence(design, population, supporting numbers)
To provide easily accessible and relatively abundant sources of human β- or γ-actin (i.e. cytoplasmic actins), we developed Saccharomyces cerevisiae strains that express each as their sole source of actin.