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Study · Animal study (in vivo) · rat · 2023

6 results

Kisspeptin Suppresses Inflammasome-NLRP3 Activation and Pyroptosis Caused by Hypothyroidism at the Maternal-Fetal Interface of Rats.

Santos BR, Cordeiro JMDA, Santos LC, Santana LDS, Nascimento AEJ, Silva JF

International journal of molecular sciences6 Apr 2023Cited by 17 (Europe PMC)

PMID37047793 (opens in a new tab)PMCIDPMC10095583 (opens in a new tab)DOI10.3390/ijms24076820 (opens in a new tab)PepBankPUB-37047793
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Summary

Gestational diseases such as preeclampsia and gestational diabetes cause inflammasome activation and pyroptosis in the placenta and changes in placental kisspeptin levels. Although maternal hypothyroidism also reduces the kisspeptin/Kiss1R system at the maternal-fetal interface, there is still no information on whether this dysfunction causes inflammasome activation and pyroptosis in the placenta or influences the modulatory role of kisspeptin in these processes. This study aimed to evaluate whether hypothyroidism activates the inflammasome-NLRP3 pathway and pyroptosis at the maternal-fetal interface of rats and whether kisspeptin can modulate these processes. Hypothyroidism was induced in Wistar rats by the administration of propylthiouracil. Kisspeptin-10 (Kp10) treatment began on the 8th day of gestation (DG). Gene and/or protein expressions of NLRP3, Caspase 1, IL-1β, IL-18, and Gasdermin D (Gsmd) were evaluated in the deciduae and placentae at the 18th DG. Hypothyroidism increased the decidual and placental stainings of NLRP3, IL-1β, and Gasdermin D, and increased the gene expressions of Nlrp3, Ilβ, and Il18 in the placenta and of Gsmd in the decidua. Treatment with Kp10 suppressed the increase in NLRP3/Nlrp3, IL-1β, Il18, and Gasdermin D/Gsmd caused by hypothyroidism at the maternal-fetal interface. However, Kp10 increased the placental gene expressions of Casp1 and Il1β. The findings demonstrated that maternal hypothyroidism activated the inflammasome-NLRP3 pathway and pyroptosis at the maternal-fetal interface of rats and that treatment with Kp10 was able to block these processes, thus suggesting that kisspeptin analogues may be promising in the treatment of gestational diseases that involve inflammasome activation and pyroptosis.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In pregnant hypothyroid rats, Kp10 suppressed the hypothyroidism-induced increase in NLRP3 at the maternal-fetal interface.

    In plain wordsIn pregnant rats with low thyroid function, kisspeptin‑10 reduced the rise in an inflammation protein, NLRP3, in the placenta.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseNLRP3 expression at the maternal-fetal interface
    Study

    ratn: not reported in source

    Wistar rats with propylthiouracil-induced hypothyroidism, pregnant, maternal-fetal interface
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with Kp10 suppressed the increase in NLRP3/Nlrp3, IL-1β, Il18, and Gasdermin D/Gsmd caused by hypothyroidism at the maternal-fetal interface.
    2 context sentences
    Summary · context
    Hypothyroidism was induced in Wistar rats by the administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp10) treatment began on the 8th day of gestation (DG).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In pregnant hypothyroid rats, Kp10 suppressed the hypothyroidism-induced increase in IL-1β at the maternal-fetal interface.

    In plain wordsIn pregnant rats with low thyroid function, kisspeptin‑10 reduced the rise in the inflammation signal IL-1β in the placenta.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseIL-1β expression at the maternal-fetal interface
    Study

    ratn: not reported in source

    Wistar rats with propylthiouracil-induced hypothyroidism, pregnant, maternal-fetal interface
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with Kp10 suppressed the increase in NLRP3/Nlrp3, IL-1β, Il18, and Gasdermin D/Gsmd caused by hypothyroidism at the maternal-fetal interface.
    2 context sentences
    Summary · context
    Hypothyroidism was induced in Wistar rats by the administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp10) treatment began on the 8th day of gestation (DG).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In pregnant hypothyroid rats, Kp10 suppressed the hypothyroidism-induced increase in Il18 at the maternal-fetal interface.

    In plain wordsIn pregnant rats with low thyroid function, kisspeptin‑10 reduced the rise in the inflammation signal Il18 in the placenta.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseIl18 expression at the maternal-fetal interface
    Study

    ratn: not reported in source

    Wistar rats with propylthiouracil-induced hypothyroidism, pregnant, maternal-fetal interface
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with Kp10 suppressed the increase in NLRP3/Nlrp3, IL-1β, Il18, and Gasdermin D/Gsmd caused by hypothyroidism at the maternal-fetal interface.
    2 context sentences
    Summary · context
    Hypothyroidism was induced in Wistar rats by the administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp10) treatment began on the 8th day of gestation (DG).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In pregnant hypothyroid rats, Kp10 suppressed the hypothyroidism-induced increase in Gasdermin D at the maternal-fetal interface.

    In plain wordsIn pregnant rats with low thyroid function, kisspeptin‑10 reduced the rise in Gasdermin D, a cell-death marker, in the placenta.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseGasdermin D expression at the maternal-fetal interface
    Study

    ratn: not reported in source

    Wistar rats with propylthiouracil-induced hypothyroidism, pregnant, maternal-fetal interface
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with Kp10 suppressed the increase in NLRP3/Nlrp3, IL-1β, Il18, and Gasdermin D/Gsmd caused by hypothyroidism at the maternal-fetal interface.
    2 context sentences
    Summary · context
    Hypothyroidism was induced in Wistar rats by the administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp10) treatment began on the 8th day of gestation (DG).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In pregnant hypothyroid rats, Kp10 increased placental gene expression of Casp1.

    In plain wordsIn pregnant rats with low thyroid function, kisspeptin‑10 raised the activity of the Casp1 gene in the placenta.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlacental Casp1 gene expression
    Study

    ratn: not reported in source

    Wistar rats with propylthiouracil-induced hypothyroidism, pregnant, maternal-fetal interface
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, Kp10 increased the placental gene expressions of Casp1 and Il1β.
    2 context sentences
    Summary · context
    Hypothyroidism was induced in Wistar rats by the administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp10) treatment began on the 8th day of gestation (DG).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In pregnant hypothyroid rats, Kp10 increased placental gene expression of Il1β.

    In plain wordsIn pregnant rats with low thyroid function, kisspeptin‑10 raised the activity of the Il1β gene in the placenta.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlacental Il1β gene expression
    Study

    ratn: not reported in source

    Wistar rats with propylthiouracil-induced hypothyroidism, pregnant, maternal-fetal interface
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, Kp10 increased the placental gene expressions of Casp1 and Il1β.
    2 context sentences
    Summary · context
    Hypothyroidism was induced in Wistar rats by the administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp10) treatment began on the 8th day of gestation (DG).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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